Retinal and retinocortical times to pattern stimulation in amblyopic children

Teping, C.; Kamps, I; Reim, Martin

doi:10.1007/bf00155028

Cited by 7 publications

(3 citation statements)

References 6 publications

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“…Our results are in agreement with those in another study. 19 However, although simultaneous PERG and VEP recordings were performed in a preceding study, 10 RCT was not evaluated. Therefore, apart from the data proposed by Teping et al, 19 there is no further information in the literature regarding postretinal neural conduction in AM patients.…”

Section: Neural Conduction Along Postretinal Visual Pathways: Rct Datamentioning

confidence: 99%

Electrophysiological Detection of Delayed Postretinal Neural Conduction in Human Amblyopia

Parisi

Scarale

Balducci

et al. 2010

Invest. Ophthalmol. Vis. Sci.

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Section: Neural Conduction Along Postretinal Visual Pathways: Rct Datamentioning

confidence: 99%

Electrophysiological Detection of Delayed Postretinal Neural Conduction in Human Amblyopia

Parisi

Scarale

Balducci

et al. 2010

Invest. Ophthalmol. Vis. Sci.

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“…There were many studies on patients with amblyopia in P-ERG changes, but results still remained inconsistent. Tepping et al [21], Guttob et al [15] and Hess et al [16] found no signi cant difference between amblyopic eyes and the normal control eyes in either amplitude or latency of P 50 and N 95 . Tugcu B et al [13] and Arden et al [14], using the same stimulation patterns, found that among patients with amblyopia, there were no signi cant differences in the amblyopic eyes' P-ERG latency compared to the fellow eyes, but P 50 amplitude in the amblyopic eyes declined signi cantly when compared to the normal control eyes, indicating the decline of retinal ganglion cell function.…”

Section: Discussionmentioning

confidence: 99%

Retinal Thickness and P-ERG Changes in Adult Patients With Anisometropic and Strabismic Amblyopia

Gao

Shao

et al. 2021

Preprint

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Objective To investigate the changes of retinal thickness and P-ERG signals in adult patients with anisometropic and strabismic amblyopia. Methods Sixty patients with monocular adult amblyopia, including 30 anisometropic amblyopes (AA group) and 30 strabismic amblyopes (SA group), were enrolled in our study at the outpatient clinic of The Hefei First People’s Hospital Hospital of Anhui medical University from June 2019 to November 2020. Retinal nerve fiber layer (RNFL) thickness was measured within 3.4 mm diameter range surrounding the optic nerve, and ganglion cell complex (GCC) layer thickness within 6 mm diameter range surrounding the fovea by an Optovue RTVue OCT in both amblyopic and fellow eyes. The amplitude and latency of P50 and N95 in P-ERG were recorded by a Roland electrophysiology instrument under two stimulation conditions with different temporal and spatial frequencies that were designed to bias the parvocellular and magnocellular pathways respectively. Data between amblyopic and fellow eyes was statistically analyzed by paired t test. The correlation between axial length and parameters of OCT and P-ERG was examined by Pearson correlation test. Results (1) Changes in RNFL thickness: In the AA group, RNFL thickness in temporal sector was significantly thinner (p = 0.033), while that in the nasal, superior and inferior sectors increased (p < 0.05) compared with fellow eyes. In SA group, no significant difference (each sector p > 0.05) was found between amblyopic eyes and fellow eyes. (2) Changes in GCC thickness: Compared with fellow eyes, in the AA group, GCC layer thickness of amblyopic eyes was significantly increased (p = 0.039), whereas in the SA group, we did not find a significant difference between amblyopic eyes and fellow eyes (p > 0.05). (3) P-ERG stimulated mode biased the parvocellular pathway: When compared with fellow eyes (n = 15), in the AA group, the amplitudes of P50 (p = 0.004) and N95 (p = 0.038) were significantly decreased in amblyopic eyes, but no significant latent time difference (p > 0.05) was found. In the same stimulus pattern, no statistically significant difference (n = 15, p > 0.05) between amblyopic eyes and fellow eyes was found in the amplitude and latency of P50 and N95 in the SA group. (4) P-ERG stimulated mode biased the magnocellular pathway: The amplitude and latency of P50 and N95 showed no statistically significant difference (p > 0.05) in either the AA group or the SA group. (5) We found no significant correlation between axial length and OCT, P-ERG parameters (p > 0.05) in either group. Conclusion Our results showed that the alterations in structure and function of retina that could be seen in adult anisometropic amblyopia were not found in adult strabismic amblyopia group. The functional loss in anisometropic amblyopia was found to bias to a damage of partial ganglion cells by the parvocellular pathway. These findings indicated that the pathological mechanisms were different between anisometropic and strabismic amblyopia.

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“…In detail, most of the previous studies that were conducted using transient PERG found a reduction in the amplitude with an increase in the latency of the response in the amblyopic eye compared to the control eye, 26 , 55 whereas other investigators showed no difference between the healthy control group and amblyopic eyes as regards both amplitude and latency. 10 , 27 …”

Section: Discussionmentioning

confidence: 99%

Steady-state pattern electroretinogram and frequency doubling technology in anisometropic amblyopia

Schiavi

Tassi

Finzi

et al. 2016

OPTH

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BackgroundSteady-state pattern electroretinogram (PERG) and frequency doubling technology (FDT) perimetry can be used to selectively investigate the activity of the M-Y ganglion cells in adult anisometropic amblyopes.MethodsFifteen normal subjects (mean 27.8±4.1 years) and 15 adults with anisometropic amblyopia (mean 28.7±5.9 years) were analyzed using steady-state PERG and FDT.ResultsThe amplitude of steady-state PERG was significantly different not only among the control group and both the amblyopic eye (P=0.0001) and the sound eye group (P=0.0001), but also between the latter two groups (P=0.006). The difference in FDT mean deviation was statistically significant not only between the control group and amblyopic eye group (P=0.0002), but also between the control group and the sound eye group (P=0.0009). The FDT pattern standard deviation was significantly higher in the control group rather than in the amblyopic eye (P=0.0001) or the sound eye group (P=0.0001). A correlation was found between the reduction in PERG amplitude and the increase in FDT-pattern standard deviation index not only in amblyopic (P=0.0025) and sound (P=0.0023) eyes, but also in the healthy control group (P=0.0001).ConclusionThese data demonstrate that in anisometropic amblyopia, there is an abnormal functionality of a subgroup of the magnocellular ganglion cells (M-Y), and the involvement of these cells, together with the parvocellular pathway, may play a key role in the clinical expression of the disease.

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Retinal and retinocortical times to pattern stimulation in amblyopic children

Cited by 7 publications

References 6 publications

Electrophysiological Detection of Delayed Postretinal Neural Conduction in Human Amblyopia

Electrophysiological Detection of Delayed Postretinal Neural Conduction in Human Amblyopia

Retinal Thickness and P-ERG Changes in Adult Patients With Anisometropic and Strabismic Amblyopia

Steady-state pattern electroretinogram and frequency doubling technology in anisometropic amblyopia

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