Electrophysiological Detection of Delayed Postretinal Neural Conduction in Human Amblyopia

Parisi, Vincenzo; Scarale, Maria Elisa; Balducci, Nicole; Fresina, Michela; Campos, Emilio C.

doi:10.1167/iovs.10-5412

Cited by 36 publications

(45 citation statements)

References 47 publications

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“…This is further supported by the fact that the behavioral effects of noise correlated with the individual variations in P1 noise-modulation of the amblyopic eye measured over the right hemisphere, since early face processing involving the P1 and N170 component is right lateralized. This is in accordance with the known low-level visual processing deficits of amblyopia [31]–[34].…”

Section: Discussionsupporting

confidence: 91%

“…However, there are cases where increased latency jitter might be a serious concern such as autism [28] and even more so amblyopia [24]. In fact, the possibility that impaired temporal structure of neural responses might contribute to the severe amblyopic amplitude decrease found in the ERP results [31]–[34] is supported by previous findings showing that in strabismic cats neuronal response latencies could be more variable in visual cortical neurons driven by the amblyopic eye [35]–[37] as well as by the human electrophysiological results revealing increased latency jitter of the ERP components across trials in the amblyopic as compared to the fellow eye [24]. To circumvent this possible confound, we performed a single-trial ERP analysis, detecting peaks on each trial, which enabled us to investigate the effect of noise sensitivity in the trial-by-trial amplitude and latency of the ERP components.…”

Section: Resultsmentioning

confidence: 99%

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How the Visual Cortex Handles Stimulus Noise: Insights from Amblyopia

et al. 2013

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Adding noise to a visual image makes object recognition more effortful and has a widespread effect on human electrophysiological responses. However, visual cortical processes directly involved in handling the stimulus noise have yet to be identified and dissociated from the modulation of the neural responses due to the deteriorated structural information and increased stimulus uncertainty in the case of noisy images. Here we show that the impairment of face gender categorization performance in the case of noisy images in amblyopic patients correlates with amblyopic deficits measured in the noise-induced modulation of the P1/P2 components of single-trial event-related potentials (ERP). On the other hand, the N170 ERP component is similarly affected by the presence of noise in the two eyes and its modulation does not predict the behavioral deficit. These results have revealed that the efficient processing of noisy images depends on the engagement of additional processing resources both at the early, feature-specific as well as later, object-level stages of visual cortical processing reflected in the P1 and P2 ERP components, respectively. Our findings also suggest that noise-induced modulation of the N170 component might reflect diminished face-selective neuronal responses to face images with deteriorated structural information.

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Section: Discussionsupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

How the Visual Cortex Handles Stimulus Noise: Insights from Amblyopia

et al. 2013

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“…In agreement with previously published studies, 6,7,19,20,21,27,28 simultaneous PERG and VEP recordings were performed using the methods as follows.…”

Section: Electrophysiological Examinationsmentioning

confidence: 95%

“…27,33 During a recording session, simultaneous VEPs and PERGs were recorded at least twice (2 to 6 times) and the resulting waveforms were superimposed to check the repeatability of results. 27,33 During a recording session, simultaneous VEPs and PERGs were recorded at least twice (2 to 6 times) and the resulting waveforms were superimposed to check the repeatability of results.…”

Section: Vep Recordingsmentioning

confidence: 99%

Effects of Coenzyme Q10 in Conjunction With Vitamin E on Retinal-evoked and Cortical-evoked Responses in Patients With Open-angle Glaucoma

Parisi

Centofanti

Gandolfi

et al. 2014

Journal of Glaucoma

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“…In addition, some studies have observed abnormal neural responses in subjects with amblyopia using electrophysiological techniques [11–14]. However, the impairments in amblyopia are not completely understood.…”

Section: Introductionmentioning

confidence: 99%

Cognitive processing of orientation discrimination in anisometropic amblyopia

et al. 2017

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Cognition is very important in our daily life. However, amblyopia has abnormal visual cognition. Physiological changes of the brain during processes of cognition could be reflected with ERPs. So the purpose of this study was to investigate the speed and the capacity of resource allocation in visual cognitive processing in orientation discrimination task during monocular and binocular viewing conditions of amblyopia and normal control as well as the corresponding eyes of the two groups with ERPs. We also sought to investigate whether the speed and the capacity of resource allocation in visual cognitive processing vary with target stimuli at different spatial frequencies (3, 6 and 9 cpd) in amblyopia and normal control as well as between the corresponding eyes of the two groups. Fifteen mild to moderate anisometropic amblyopes and ten normal controls were recruited. Three-stimulus oddball paradigms of three different spatial frequency orientation discrimination tasks were used in monocular and binocular conditions in amblyopes and normal controls to elicit event-related potentials (ERPs). Accuracy (ACC), reaction time (RT), the latency of novelty P300 and P3b, and the amplitude of novelty P300 and P3b were measured. Results showed that RT was longer in the amblyopic eye than in both eyes of amblyopia and non-dominant eye in control. Novelty P300 amplitude was largest in the amblyopic eye, followed by the fellow eye, and smallest in both eyes of amblyopia. Novelty P300 amplitude was larger in the amblyopic eye than non-dominant eye and was larger in fellow eye than dominant eye. P3b latency was longer in the amblyopic eye than in the fellow eye, both eyes of amblyopia and non-dominant eye of control. P3b latency was not associated with RT in amblyopia. Neural responses of the amblyopic eye are abnormal at the middle and late stages of cognitive processing, indicating that the amblyopic eye needs to spend more time or integrate more resources to process the same visual task. Fellow eye and both eyes in amblyopia are slightly different from the dominant eye and both eyes in normal control at the middle and late stages of cognitive processing. Meanwhile, abnormal extents of amblyopic eye do not vary with three different spatial frequencies used in our study.

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Electrophysiological Detection of Delayed Postretinal Neural Conduction in Human Amblyopia

Cited by 36 publications

References 47 publications

How the Visual Cortex Handles Stimulus Noise: Insights from Amblyopia

How the Visual Cortex Handles Stimulus Noise: Insights from Amblyopia

Effects of Coenzyme Q10 in Conjunction With Vitamin E on Retinal-evoked and Cortical-evoked Responses in Patients With Open-angle Glaucoma

Cognitive processing of orientation discrimination in anisometropic amblyopia

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