Retention of a spatial task after intraperitoneal, subcutaneous or intravenous injections of equal doses of atropine

Rauch, Terry M.; Gallego, Edurne Mazarico; Welch, D.I.

doi:10.1016/s0024-3205(88)80009-2

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…Whishaw (1985) reported that atropine sulfate treated rats can acquire a place response, but at a significantly slower rate than controls. Results from a recent study (Rauch et al, 1988) show that atropinized rats improve their choice accuracy over subsequent trials at 10, 20, 30, 40, and 50 minutes after injection. The improvement in spatial performance demonstrated by atropinized rats may also be due to developing a nonmapping strategy when retrieval of the existing spatial map is inhibited by the drug.…”

Section: Discussionmentioning

confidence: 97%

“…A 30 rag/ kg, iv dose was chosen since we found this dose to disrupt first choice accuracy and escape latency measures of spatial retention (Rauch et al, 1988). The minutes prior to injection with atropine sulfate or saline, each animal was tested for one trial on retention of the spatial task, then injected and returned to its home cage.…”

Section: Atropine Administration and Spatial Retention Proceduresmentioning

confidence: 99%

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Low doses of atropine sulfate impair retention of a well-learned spatial task

Rauch

Welch

Gallego

1989

J Neural Transm Gen Sect

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Retention of a well-learned spatial task was assessed in rats 10 minutes prior to, and 10, 20, 30, 40, and 50 minutes after treatment with 3, 10 or 30 mg/kg, iv, atropine sulfate or the equivalent volume of saline, iv. There was a variable dose effect for escape latency and choice accuracy measures of spatial retention. A relatively large dose of atropine sulfate (30 mg/kg, iv) significantly impaired choice accuracy and escape latency compared with the control group. Moreover, impairment in choice accuracy was observed with smaller doses of atropine sulfate (3, 10 mg/kg, iv) than have previously been shown to disrupt spatial retention.

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Section: Discussionmentioning

confidence: 97%

Section: Atropine Administration and Spatial Retention Proceduresmentioning

confidence: 99%

Low doses of atropine sulfate impair retention of a well-learned spatial task

Rauch

Welch

Gallego

1989

J Neural Transm Gen Sect

View full text Add to dashboard Cite

show abstract

Atropine sulfate impairs selective parameters of performance in the Morris water maze

1990

J Neural Transm Gen Sect

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Twelve rats were trained to learn the location of a spatially fixed platform hidden in a Morris water maze. Asymptotic performance was achieved over six training days (10 trials/day). Then retention of the spatial task was assessed 30 min after treatment with 5, 25, 50, 75, or 100 mg/kg, ip, atropine sulfate or the equivalent volume of saline. There was a significant drug effect on escape latency, swim distance, swim speed and swim path measures of spatial performance. There was no significant drug effect on heading error; atropinized animals initially headed toward the escape platform over the first 12 cm of their swim path. However, treatment with atropine sulfate significantly disrupted the usual, direct swim path used to reach the hidden escape platform. Atropinized animals frequently swam a spiraled or looping pattern to locate the platform. We suggest that cholinergic blockade may significantly disrupt the processing of visual cues which rats use in place navigation tasks.

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