Hypothermia impairs performance in the Morris water maze

Rauch, Terry M.; Welch, D.I.; Gallego, L.

doi:10.1016/0031-9384(89)90273-4

Cited by 43 publications

(21 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In adult mice, core body temperature drops $5-6 C over the course of five trials in quick succession, and this drop in temperature correlates with a reduction in swimming speed (Iivnonen et al, 2003). In adult rats, artificially lowering body temperature (Rauch et al, 1989) or brain temperature (Moser & Anderson, 1994) to $7-9 C below baseline impairs acquisition and retention of the platform location and causes motor disturbances such as decreased swimming speed and difficulty in climbing onto the platform. Because of young rats' small size, they are likely to experience a severe drop in body temperature as a result of exposure to cool water, and such hypothermia may cause performance deficits that could mask learning ability in the water task.…”

Section: Discussionmentioning

confidence: 99%

“…All training and testing for each age group was given during a single day to allow for unambiguous identification of the first day in development at which place and cued learning emerge. Because hypothermia is known to impair performance in the water task (Iivnonen, Nurminen, Harri, Tanila, & Puolivali, 2003;Moser & Anderson, 1994;Rauch, Welch, & Gallego, 1989), and young rats may be particularly susceptible to hypothermia due to their small size, care was taken to maintain body temperature throughout training and testing. Performance in the water task, particularly during the post-training probe trial, was assessed using several dependent measures to provide a detailed characterization of cued and place navigation for the ages of rats examined.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of developmental trajectories for place and cued navigation in the morris water task

Akers

Hamilton

2007

Developmental Psychobiology

View full text Add to dashboard Cite

Previous studies investigating the development of place and cued learning using the Morris water task are in disagreement regarding the day in development that each type of learning emerges. Here, place and cued navigation in the water task were examined in differently aged groups of young male and female rats (P17, P18, P19, P20, and P24) during a single day of training. When only distal cues were present, P20 and P24 but not younger rats learned the location of the hidden platform. In contrast, when a proximal cue marked the platform location, rats as young as P17 showed evidence of cue-controlled navigation, although only P18 and older rats exhibited cued learning. In line with most previous studies, these results indicate that cued learning emerges earlier in development than place learning and support a dissociation of developmental trajectories for the neural systems underlying the two types of navigation. ß 2007 Wiley Periodicals, Inc. Dev Psychobiol 49: 553-564, 2007.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of developmental trajectories for place and cued navigation in the morris water task

Akers

Hamilton

2007

Developmental Psychobiology

View full text Add to dashboard Cite

show abstract

“…This lowered body temperature could have implications for the interpretation of WM spatial memory deficits in the PDAPP mouse if water temperature is not sufficiently controlled, as hypothermic animals are impaired in WM learning (Rauch et al 1989). In aged PDAPP mice, the decrease in comparative thermoregulation was significant, while LMA levels were typical of control animals.…”

Section: Transgenic Mouse Modelsmentioning

confidence: 99%

“…In aged PDAPP mice, the decrease in comparative thermoregulation was significant, while LMA levels were typical of control animals. This lowered body temperature could have implications for the interpretation of WM spatial memory deficits in the PDAPP mouse if water temperature is not sufficiently controlled, as hypothermic animals are impaired in WM learning (Rauch et al 1989).…”

Section: Transgenic Mouse Modelsmentioning

confidence: 99%

Behavioral phenotypes of amyloid‐based genetically modified mouse models of Alzheimer's disease

Kobayashi

Chen

2005

Genes Brain and Behavior

163

123

View full text Add to dashboard Cite

Alzheimer's disease (AD) is the most common neurodegenerative affliction of the elderly, presenting with progressive memory loss and dementia and terminating with death. There have been significant advances in understanding the biology and subsequent diagnosis of AD; however, the furious pace of research has not yet translated into a disease-modifying treatment. While scientific inquiry in AD is largely centered on identifying biological players and pathological mechanisms, the day-to-day realities of AD patients and their caregivers revolve around their steady and heartbreaking cognitive decline. In the past decade, AD research has been fundamentally transformed by the development of genetically modified animal models of amyloid-driven neurodegeneration. These important in vivo models not only replicate some of the hallmark pathology of the disease, such as plaque-like amyloid accumulations and astrocytic inflammation, but also some of the cognitive impairments relevant to AD. In this article, we will provide a detailed review of the behavioral and cognitive deficits present in several transgenic mouse models of AD and discuss their functional changes in response to experimental treatments.

show abstract

“…First, we aimed to find two water temperatures at which rats perform in the water maze at a different acquisition curve, so as to subsequently evaluate the effect of corticosterone administration under such conditions. Water temperatures at 18°C or lower were not considered since they induce stereotyped behaviour in the form of looping along the perimeter of the pool (unpublished observations ;Rauch et aL, 1989). Based on pilot experiments indicating behavioural differences, rats were trained at either 19°C or 25°C.…”

Section: Water Maze Per$ormancementioning

confidence: 99%

Experience‐dependent Facilitating Effect of Corticosterone on Spatial Memory Formation in the Water Maze

Sandi

Loscertales

Guaza

1997

Eur J of Neuroscience

396

249

View full text Add to dashboard Cite

Stress‐related adrenal steroid hormones modulate brain and cognitive function. Electrophysiological studies, including primed burst potentiation and long‐term potentiation, have indicated concentration‐dependent inverted U‐shape effects of corticosterone in hippocampal function and plasticity. Here, we explored the role of corticosterone in the consolidation and long‐term retrieval of spatial learning in the Morris water maze task in rats. We postulated that corticosterone actions might be experience‐dependent with regard to stimulus intensity, such as differential water temperatures. Indeed, rats trained at 19°C showed a quicker rate of acquisition and better long‐term retention than rats trained at 25°C water. In addition, post‐training corticosterone levels, on the first training day, were significantly higher in rats in the 19°C group than in the 25°C group. Performance of rats trained at 25°C, but not at 19°C, water was improved by injecting them i.p. with corticosterone immediately after each training session. Thus, the effect of exogenously administered corticosterone appears to be experience‐dependent, with the experience‐induced corticosterone concentrations as a critical factor determining the cognitive consequences of steroid treatment. Therefore, this work indicates a facilitating corticosterone action, during the post‐training period, on the neural mechanisms determining the strength of information storage under acute, physiological conditions.

show abstract

Hypothermia impairs performance in the Morris water maze

Cited by 43 publications

References 33 publications

Comparison of developmental trajectories for place and cued navigation in the morris water task

Comparison of developmental trajectories for place and cued navigation in the morris water task

Behavioral phenotypes of amyloid‐based genetically modified mouse models of Alzheimer's disease

Experience‐dependent Facilitating Effect of Corticosterone on Spatial Memory Formation in the Water Maze

Contact Info

Product

Resources

About