Resveratrol–zinc combination for prostate cancer management

Singh, Chandra K.; Pitschmann, Anna; Ahmad, Nihal

doi:10.4161/cc.29334

Cited by 22 publications

(21 citation statements)

References 84 publications

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“…Alterations in Intracellular and serum zinc (II) levels as a result of imbalance of zinc transporters in prostate cancer patients has been previously delineated (226). While zinc is available at a very high concentration in healthy prostate tissues, it significantly diminishes in the course of prostate carcinogenesis and its intracellular level has been reported to be inversely correlated with prostate cancer progression (227). It has been noted that the level of zinc in prostate tissue declines early preceding histopathological alterations and continues to diminish throughout the progression phase toward castration-resistant disease (228)(229)(230).…”

Section: Zincmentioning

confidence: 99%

Chemoprevention of Prostate Cancer by Natural Agents: Evidence from Molecular and Epidemiological Studies

2019

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Background/Aim: Prostate cancer is one of the most common cancers in men which remains a global public health issue. Treatment of prostate cancer is becoming increasingly intensive and aggressive, with a corresponding increase in resistance, toxicity and side effects. This has revived an interest in nontoxic and cost-effective preventive strategies including dietary compounds due to the multiple effects they have been shown to have in various oncogenic signalling pathways, with relatively few significant adverse effects. Materials and Methods: To identify such dietary components and micronutrients and define their prostate cancer-specific actions, we systematically reviewed the current literature for the pertinent mechanisms of action and effects on the modulation of prostate carcinogenesis, along with relevant updates from epidemiological and clinical studies. Results: Evidence from various recent experimental, clinical and epidemiological studies indicates that select dietary micronutrients (i.e., lycopene, epigallocatechin gallate, sulforaphane, indole-3-carbinol, resveratrol, quercetin, curcumin & piperine) and zinc play a key role in prostate cancer prevention and progression and therefore hold great promise for the future overall management of prostate cancer. Conclusion: A formulation that comprises these micronutrients using the optimal, safest form and dosing should be investigated in future prostate cancer chemoprevention studies and as part of standard prostate cancer therapy.

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Section: Zincmentioning

confidence: 99%

Chemoprevention of Prostate Cancer by Natural Agents: Evidence from Molecular and Epidemiological Studies

2019

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“…Another recent report suggests Zn, in combination with RSV, as a novel approach for PCa management. Zn is abundantly available in healthy prostates, but with PCa progression, it reduces significantly [ 98 ]. RSV, in combination with Zn, was reported to increase the total cellular Zn and intracellular free labile Zn in normal human prostate epithelial cells [ 99 ].…”

Section: Dietary Polyphenols In Prostate Cancermentioning

confidence: 99%

Dietary Polyphenols in Prevention and Treatment of Prostate Cancer

Lall

Syed

Adhami

et al. 2015

IJMS

163

158

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Prostate cancer is the most prevalent disease affecting males in many Western countries, with an estimated 29,480 deaths in 2014 in the US alone. Incidence rates for prostate cancer deaths have been decreasing since the early 1990s in men of all races/ethnicities, though they remain about 60% higher in African Americans than in any other group. The relationship between dietary polyphenols and the prevention of prostate cancer has been examined previously. Although results are sometimes inconsistent and variable, there is a general agreement that polyphenols hold great promise for the future management of prostate cancer. Various dietary components, including polyphenols, have been shown to possess anti-cancer properties. Generally considered as non-toxic, dietary polyphenols act as key modulators of signaling pathways and are therefore considered ideal chemopreventive agents. Besides possessing various anti-tumor properties, dietary polyphenols also contribute to epigenetic changes associated with the fate of cancer cells and have emerged as potential drugs for therapeutic intervention. Polyphenols have also been shown to affect post-translational modifications and microRNA expressions. This article provides a systematic review of the health benefits of selected dietary polyphenols in prostate cancer, especially focusing on the subclasses of polyphenols, which have a great effect on disease prevention and treatment.

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“…54 Thus, ZnCl 2 or zinc compounds have been used in in vitro and in vivo studies to improve the cytotoxic effect of antineoplastic agents through several mechanisms. 55, 56, 57, 58, 59, 60, 61, 62 If experimentally verified in in vivo model(s) of hyperglycemia, such combination therapy with ZnCl 2 and antineoplastic agents may lead to novel means toward management of hyperglycemic cancer patients.…”

Section: Discussionmentioning

confidence: 94%

ZnCl2 sustains the adriamycin-induced cell death inhibited by high glucose

Garufi

Trisciuoglio²,

Cirone

et al. 2016

Cell Death Dis

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Hyperglycemia, the condition of high blood glucose, is typical of diabetes and obesity and represents a significant clinical problem. The relationship between hyperglycemia and cancer risk has been established by several studies. Moreover, hyperglycemia has been shown to reduce cancer cell response to therapies, conferring resistance to drug-induced cell death. Therefore, counteracting the negative effects of hyperglycemia may positively improve the cancer cell death induced by chemotherapies. Recent studies showed that zinc supplementation may have beneficial effects on glycemic control. Here we aimed at evaluating whether ZnCl2 could counteract the high-glucose (HG) effects and consequently restore the drug-induced cancer cell death. At the molecular level we found that the HG-induced expression of genes known to be involved in chemoresistance (such as HIF-1α, GLUT1, and HK2 glycolytic genes, as well as NF-κB activity) was reduced by ZnCl2 treatment. In agreement, the adryamicin (ADR)-induced apoptotic cancer cell death was significantly impaired by HG and efficiently re-established by ZnCl2 cotreatment. Mechanistically, the ADR-induced c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) phosphorylation, inhibited by HG, was efficiently restored by ZnCl2. The JNK involvement in apoptotic cell death was assessed by the use of JNK dominant-negative expression vector that indeed impaired the ZnCl2 ability to restore drug-induced cell death in HG condition. Altogether, these findings indicate that ZnCl2 supplementation efficiently restored the drug-induced cancer cell death, inhibited by HG, by both sustaining JNK activation and counteracting the glycolytic pathway.

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Resveratrol–zinc combination for prostate cancer management

Cited by 22 publications

References 84 publications

Chemoprevention of Prostate Cancer by Natural Agents: Evidence from Molecular and Epidemiological Studies

Chemoprevention of Prostate Cancer by Natural Agents: Evidence from Molecular and Epidemiological Studies

Dietary Polyphenols in Prevention and Treatment of Prostate Cancer

ZnCl2 sustains the adriamycin-induced cell death inhibited by high glucose

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