Resveratrol reduces obesity in high-fat diet-fed mice via modulating the composition and metabolic function of the gut microbiota

Wang, Pan; Gao, Jianpeng; Ke, Weixin; Wang, Jing; Li, Daotong; Liu, Ruolin; Jia, Yan; Wang, Xuehua; Chen, Xin; Chen, Fang; Hu, Xiaosong

doi:10.1016/j.freeradbiomed.2020.04.013

Cited by 144 publications

(143 citation statements)

References 64 publications

Supporting

Mentioning

126

Contrasting

Order By: Relevance

“…ratio along with a significant reduction in body weight and abdominal fat, decreased lipids deposition and increased antioxidant status. Similar obesity-relieving and microbe-modulating effect of resveratrol in mice was also observed in the study byWang et al (2020), characterised by increased Blautia abundance and decreased Desulfovibrio and Lachnospiraceae_ NK4A136_group abundance.…”

supporting

confidence: 85%

Manipulating effects of fruits and vegetables on gut microbiota – a critical review

Lin

Bordiga

Brennan

et al. 2021

Int J of Food Sci Tech

View full text Add to dashboard Cite

The objective of the current review was to systematically investigate health-promoting manipulating effects of fruits and vegetables (F&V) on the gut microbiota. The function of gut microbes was found to promote health effects in the host by scavenging free radicals, modulating immune system, alleviating obesity and diabetes. Masters that manipulate the gut microbiota are the phytochemicals within specific types of F&V, where polyphenols account for the largest proportion, along with alkaloids, terpenes, nitrogen-containing compounds, polysaccharides and natural pigments present in plants. These bioactive compounds exhibit the regulative influences on gut microorganisms characterised by rescuing dysbiosis of gut microbiota, increasing/decreasing microbial abundance, restructuring microbial composition, and rebalancing gut microbial homeostasis. This review indicated that F&V extracts targeting at gut microbiota could be a new scope of ingredient selection in the field of functional food especially for amelioration of dysfunction of intestinal ecosystem.

show abstract

supporting

confidence: 85%

Manipulating effects of fruits and vegetables on gut microbiota – a critical review

Lin

Bordiga

Brennan

et al. 2021

Int J of Food Sci Tech

View full text Add to dashboard Cite

show abstract

“…Serino et al (2012) reported that treatment with prebiotic gluco-oligosaccharide (GOS) can effectively restore the abundance of S24-7 and Lactobacillus after their reduction due to the HFD [ 70 ]. In addition, supplementation with RSV can alleviate the dysregulation of intestinal microbiota caused by an HFD and increase the abundance of Lactobacillus and Bifidobacterium in the intestines [ 71 ].…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Butyrate Esters Inhibit Obesity Caused by Perinatal Exposure to Bisphenol A in Female Offspring Rats

et al. 2021

View full text Add to dashboard Cite

Resveratrol butyrate esters (RBE) are derivatives of resveratrol (RSV) and butyric acid and exhibit biological activity similar to that of RSV but with higher bioavailability. The aim of this study was designed as an animal experiment to explore the effects of RBE on the serum biochemistry, and fat deposits in the offspring rats exposed to bisphenol A (BPA), along with the growth and decline of gut microbiota. We constructed an animal model of perinatal Bisphenol A (BPA) exposure to observe the effects of RBE supplementation on obesity, blood lipids, and intestinal microbiota in female offspring rats. Perinatal exposure to BPA led to weight gain, lipid accumulation, high levels of blood lipids, and deterioration of intestinal microbiota in female offspring rats. RBE supplementation reduced the weight gain and lipid accumulation caused by BPA, optimised the levels of blood lipids, significantly reduced the Firmicutes/Bacteroidetes (F/B) ratio, and increased and decreased the abundance of S24-7 and Lactobacillus, respectively. The analysis of faecal short-chain fatty acid (SCFA) levels revealed that BPA exposure increased the faecal concentration of acetate, which could be reduced via RBE supplementation. However, the faecal concentrations of propionate and butyrate were not only significantly lower than that of acetate, but also did not significantly change in response to BPA exposure or RBE supplementation. Hence, RBE can suppress BPA-induced obesity in female offspring rats, and it demonstrates excellent modulatory activity on intestinal microbiota, with potential applications in perinatological research.

show abstract

“…High content atherogenic diets induce significant liver damage in both humans and laboratory animals and are responsible for fatty liver disease [140,141]. Studies have demonstrated the hepatoprotective effects of resveratrol in the high-fat dietary model of liver damage [142][143][144][145].…”

Section: Resveratrol In Liver Damage Induced By Atherogenic Dietmentioning

confidence: 99%

The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials

et al. 2021

View full text Add to dashboard Cite

Many studies have shown that resveratrol has a lot of therapeutic effects on liver disorders. Its administration can significantly increase the survival rate after liver transplantation, reduce fat deposition and ischemia-induced necrosis and apoptosis in Wistar rats. Resveratrol can provide Liver protection against chemical, cholestatic, and alcohol-mediated damage. It can improve glucose metabolism and lipid profile, reduce liver fibrosis, and steatosis. Additionally, it is capable of altering the fatty acid composition of the liver cells. Resveratrol may be a potential treatment option for the management of non-alcoholic fatty liver disease (NAFLD) due to its anti-inflammatory, antioxidant, and calorie-restricting effects. There are also studies that have evaluated the effect of resveratrol on lipid and liver enzyme profiles among patients with metabolic syndrome (MetS) and related disorders. Based on the extent of liver disease worldwide and the need to find new treatment possibilities, this review critically examines current in vitro and in vivo preclinical studies and human clinical studies related to liver protection.

show abstract

Resveratrol reduces obesity in high-fat diet-fed mice via modulating the composition and metabolic function of the gut microbiota

Cited by 144 publications

References 64 publications

Manipulating effects of fruits and vegetables on gut microbiota – a critical review

Manipulating effects of fruits and vegetables on gut microbiota – a critical review

Resveratrol Butyrate Esters Inhibit Obesity Caused by Perinatal Exposure to Bisphenol A in Female Offspring Rats

The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials

Contact Info

Product

Resources

About