The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials

Izzo, Carmine; Annunziata, Monica; Melara, Giuseppe; Sciorio, Roberta; Dallio, Marcello; Masarone, Mario; Federico, Alessandro; Persico, Marcello

doi:10.3390/nu13030933

Cited by 54 publications

(32 citation statements)

References 193 publications

(213 reference statements)

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“…Figures 4 and 5 show that MS is associated with an increase in liver fibrosis compared to the Control group, and the administration of RSV + QRC mixture reverted this effect. Our results are in line with experimental and clinical evidence which suggests that RSV and QRC attenuate liver inflammation and fibrosis [28,38,39].…”

Section: Discussionsupporting

confidence: 91%

“…Extensive evidence has demonstrated the beneficial effect of polyphenols on the treatment of cardiometabolic disorders. The mechanisms underlying the beneficial effects of RSV and QRC have not yet been fully elucidated and have mainly been related to epigenetic processes, intrinsic antioxidant activity, and anti-inflammatory mechanisms [23,24,28]. However, to the best of our knowledge, there are not reports on the effect of RSV and QRC on the pathways analyzed in this paper.…”

Section: Discussionmentioning

confidence: 93%

“…Numerous studies have shown that different mechanisms exert synergic action in the development or progression of liver disease linked to MS such as accumulation of fatty acids, oxidative stress, and inflammation [24,28]. On this aspect, some authors have reported that TLR4 is involved in obesity and liver damage [7,30].…”

Section: Discussionmentioning

confidence: 99%

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Resveratrol and Quercetin as Regulators of Inflammatory and Purinergic Receptors to Attenuate Liver Damage Associated to Metabolic Syndrome

Cano-Martı́nez

Bautista-Pérez

Castrejón-Téllez

et al. 2021

IJMS

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Nonalcoholic fatty liver disease (NAFLD) is considered a manifestation of metabolic syndrome (MS) and is characterized by the accumulation of triglycerides and a varying degree of hepatic injury, inflammation, and repair. Moreover, peroxisome-proliferator-activated receptors (PPARs) play a critical role in the pathophysiological processes in the liver. There is extensive evidence of the beneficial effect of polyphenols such as resveratrol (RSV) and quercetin (QRC) on the treatment of liver pathology; however, the mechanisms underlying their beneficial effects have not been fully elucidated. In this work, we show that the mechanisms underlying the beneficial effects of RSV and QRC against inflammation in liver damage in our MS model are due to the activation of novel pathways which have not been previously described such as the downregulation of the expression of toll-like receptor 4 (TLR4), neutrophil elastase (NE) and purinergic receptor P2Y2. This downregulation leads to a decrease in apoptosis and hepatic fibrosis with no changes in hepatocyte proliferation. In addition, PPAR alpha and gamma expression were altered in MS but their expression was not affected by the treatment with the natural compounds. The improvement of liver damage by the administration of polyphenols was reflected in the normalization of serum transaminase activities.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 93%

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Resveratrol and Quercetin as Regulators of Inflammatory and Purinergic Receptors to Attenuate Liver Damage Associated to Metabolic Syndrome

Cano-Martı́nez

Bautista-Pérez

Castrejón-Téllez

et al. 2021

IJMS

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“…e antioxidant and anti-inflammatory effects of resveratrol have been demonstrated in numerous studies [79] though clinical efficacy has also been argued [80,81]. e efficacy of resveratrol in treating different liver diseases has been comprehensively reviewed by Izzo and coworkers [82]. Despite the potential benefits, the oral bioavailability of resveratrol is very low.…”

Section: Liver Targeting Of Nanoparticlesmentioning

confidence: 99%

The Emerging Role of Nanomedicine in the Management of Nonalcoholic Fatty Liver Disease: A State-of-the-Art Review

Moosavian

Sathyapalan

Jamialahmadi

et al. 2021

Bioinorganic Chemistry and Applications

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Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that can lead to end-stage liver disease needing a liver transplant. Many pharmacological approaches are used to reduce the disease progression in NAFLD. However, current strategies remain ineffective to reverse the progression of NAFLD completely. Employing nanoparticles as a drug delivery system has demonstrated significant potential for improving the bioavailability of drugs in the treatment of NAFLD. Various types of nanoparticles are exploited in this regard for the management of NAFLD. In this review, we cover the current therapeutic approaches to manage NAFLD and provide a review of recent up-to-date advances in the uses of nanoparticles for the treatment of NAFLD.

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“…[ 225 ] The investigation of proper dose range should therefore be kept in mind while planning clinical trials. At this point, we would like to stress that it pays to look at resveratrol in its entire role in liver diseases and hereby recommend the excellent and very recent review by Izzo et al [ 226 ].…”

Section: Resveratrolmentioning

confidence: 99%

Combating Ischemia-Reperfusion Injury with Micronutrients and Natural Compounds during Solid Organ Transplantation: Data of Clinical Trials and Lessons of Preclinical Findings

Mauerhofer

Grumet

Schemmer

et al. 2021

IJMS

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Although extended donor criteria grafts bear a higher risk of complications such as graft dysfunction, the exceeding demand requires to extent the pool of potential donors. The risk of complications is highly associated with ischemia-reperfusion injury, a condition characterized by high loads of oxidative stress exceeding antioxidative defense mechanisms. The antioxidative properties, along with other beneficial effects like anti-inflammatory, antiapoptotic or antiarrhythmic effects of several micronutrients and natural compounds, have recently emerged increasing research interest resulting in various preclinical and clinical studies. Preclinical studies reported about ameliorated oxidative stress and inflammatory status, resulting in improved graft survival. Although the majority of clinical studies confirmed these results, reporting about improved recovery and superior organ function, others failed to do so. Yet, only a limited number of micronutrients and natural compounds have been investigated in a (large) clinical trial. Despite some ambiguous clinical results and modest clinical data availability, the vast majority of convincing animal and in vitro data, along with low cost and easy availability, encourage the conductance of future clinical trials. These should implement insights gained from animal data.

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The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials

Cited by 54 publications

References 193 publications

Resveratrol and Quercetin as Regulators of Inflammatory and Purinergic Receptors to Attenuate Liver Damage Associated to Metabolic Syndrome

Resveratrol and Quercetin as Regulators of Inflammatory and Purinergic Receptors to Attenuate Liver Damage Associated to Metabolic Syndrome

The Emerging Role of Nanomedicine in the Management of Nonalcoholic Fatty Liver Disease: A State-of-the-Art Review

Combating Ischemia-Reperfusion Injury with Micronutrients and Natural Compounds during Solid Organ Transplantation: Data of Clinical Trials and Lessons of Preclinical Findings

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