Resveratrol: influences on gene expression in human skin

Lephart, Edwin D.; Sommerfeldt, John M; Andrus, Merritt B.

doi:10.1016/j.jff.2014.07.017

Cited by 37 publications

(57 citation statements)

References 51 publications

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“…SIRTs activators have been found in nature and synthesized such as RSV and its derivatives [60] . The effect of RSV on wound healing and chronic diseases has been evaluated not only in animal model and human EpiDerm full thickness model, but also in clinical applications [61][62][63] . Taken together, SIRTs are involved in orchestrated wound healing processes and its activation provides an approach for acceleration of wound therapy.…”

Section: Resultsmentioning

confidence: 99%

Sirtuins in wound healing

Aioi

2017

Trends Immunother

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Sirtuins (SIRTs) are initially recognized as NAD + -dependent histone deacetylase. SIRTs attract attention for their role as calorie restriction-induced "longevity proteins" to be expected to extend human life span and to promote health. As advancing studies, SIRTs have been recognized as cell signaling regulators which contribute to anti-inflammation, cell differentiation and so on. Therefore, SIRTs are supposed to affect wound healing which is comprised highly orchestrated complex four phases: hemostasis, inflammation, tissue formation and tissue remodeling. This review highlights the roles of SIRTs in wound healing process and provides a foundation and impetus for future basic and clinical research.

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Section: Resultsmentioning

confidence: 99%

Sirtuins in wound healing

Aioi

2017

Trends Immunother

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“…Extracelluar matrix proteins To summarize the results of this study [54], resveratrol at 1% in gene array/qPCR experiments using a human skin model (EFT) cultures significantly increased gene expression of: 1) the anti-aging factor, SIRT1, 2) the extracellular matrix proteins (collagens-COL1A1, COLIIIA1, COLIVA1, ELN, LOX and TIMP1, etc.) and 3) several antioxidant biomarkers such as CAT, MT1H, MT2H, PCNA, SOD1, and SOD2, while at the same time, resveratrol significantly inhibited the gene expression of 4) proteinases of collagen/elastin, i.e., MMP1 and MMP9, 5) the aging and inflammatory genes (S100 A8 and A9; IL1A, IL1RII, IL6, IL8 and TNFRSF1A).…”

Section: R-equol Racemic Equol S-equol Functionmentioning

confidence: 89%

“…and 3) several antioxidant biomarkers such as CAT, MT1H, MT2H, PCNA, SOD1, and SOD2, while at the same time, resveratrol significantly inhibited the gene expression of 4) proteinases of collagen/elastin, i.e., MMP1 and MMP9, 5) the aging and inflammatory genes (S100 A8 and A9; IL1A, IL1RII, IL6, IL8 and TNFRSF1A). These data sets are displayed in Table 4 [54].…”

Section: R-equol Racemic Equol S-equol Functionmentioning

confidence: 99%

Tissue- and Organ-Specific Promoters for Expression of Heterologous Genes in Transgenic Cassava (Manihot Esculenta Crantz) Plants

Lephart

2015

Gene Technol

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Because of its accessibility, skin was one of the first organs to be examined by gene technologies. Mircoarray/mRNA techniques have demonstrated the valuable aspects of this methodology for the elucidation of and the quantification for changes in human skin related-genes. It is important to review/understand how botanicals influence human skin gene expression (by stimulation or inhibition of certain genes) and to compare these biomarkers to the known mechanisms of skin aging. This review covers how human skin genes are modulated by 1) enhanced wound healing with an extract of a well-known medicinal plant in Asia, Angelica sinensis, 2) UV sunlight exposure that represents the main cause of photoaging or extrinsic skin aging and subsequent protection by a soy extract, 3) equol and their isomers that stimulate collagen and elastin while at the same time inhibit aging and inflammatory biomarkers and 4) resveratrol, the most high profile phytochemical known by the general public that displays some properties similar to equol with the additional benefit of stimulating the anti-aging surtuin or SIRT1 biomarker. Thus, the protective influences of botanicals/ phytochemicals elucidated herein provide potential applications to improve human skin health.

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“…Resveratrol (3,5,4 0 -trihydroxy-trans-stilbene) is a polyphenolic compound naturally produced in abundance by several plants such as red grapes and Japanese knot weed. 1,2 Resveratrol (RV) is a known sirtuin activator that regulates many cellular activities which promote cell survival/delay or attenuate many age-related disorders, including its chemoprotective properties that were first reported in 1997 by John Pezzuto's laboratory.…”

Section: Introductionmentioning

confidence: 99%

Human skin gene expression: Natural (trans) resveratrol versus five resveratrol analogs for dermal applications

Lephart

Andrus

2017

Exp Biol Med (Maywood)

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Resveratrol (RV) is a polyphenolic compound naturally produced by plants. Polyphenolic compounds incorporated into medicinal products are beneficial but, RV is rapidly metabolized with an associated decline in biological activity. This study tested RV as the standard and compared five structurally modified RV analogs: butyrate, isobutyrate, palmitoate, acetate, and diacetate (to improve functionality) at 1% concentration(s) for 24 h in epiderm full thickness cultures by gene array/qPCR mRNA analysis. When silent mating type information regulation 2 homolog 1, extracellular elements (collagen1A1, 3A1, 4A1; elastin, tissue inhibitor of matrix metalloproteinase 1, fibrillin 1 laminin beta1 and matrix metalloproteinase 9), anti-aging and aging genes, inflammatory biomarkers (interleukin-1A [IL1A], IL1R2, IL-6 and IL-8), nerve growth factor, and the antioxidants (proliferating cell nuclear antigen, catalase, superoxide dismutase and metallothionein 1H/2H) were evaluated, ranking each from highest-to-lowest for gene expression: butyrate > isobutyrate > diacetate > acetate > palmitoate. This study showed that the butyrate and isobutyrate analogs are more biologically active compared to resveratrol and have potential use in topical applications to improve dermal and other health applications. Impact statement Resveratrol has been reported to have a wide variety of health benefits but its rapid metabolism especially after oral ingestion results in very low bioavailability. Notably, the first human skin gene expression study of resveratrol was not published until 2014. The purpose of this study was to determine if increased stability and biological activity could be obtained by modifying the chemical structure of natural (trans) resveratrol and quantifying human gene expression by qPCR of skin biomarkers that enhance dermal health. Five resveratrol analogs were synthesized that increased their lipophilic index to enhance tissue penetration and augment biological activities on the measured parameters that expand the current knowledge of structure/function relationships. The butyrate and isobutyrate modifications displayed gene expression values significantly above resveratrol and suggest that oral application of these and potentially other resveratrol analogs may yield similar results to improve stability and biological activity to benefit/address various disorders/diseases.

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Resveratrol: influences on gene expression in human skin

Cited by 37 publications

References 51 publications

Sirtuins in wound healing

Sirtuins in wound healing

Tissue- and Organ-Specific Promoters for Expression of Heterologous Genes in Transgenic Cassava (Manihot Esculenta Crantz) Plants

Human skin gene expression: Natural (trans) resveratrol versus five resveratrol analogs for dermal applications

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