Human skin gene expression: Natural (trans) resveratrol versus five resveratrol analogs for dermal applications

Lephart, Edwin D.; Andrus, Merritt B.

doi:10.1177/1535370217723628

Cited by 16 publications

(17 citation statements)

References 44 publications

(116 reference statements)

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“…Resveratrol significantly increased the production of antioxidants such as catalase and superoxide dismutase (SOD) as well as expression of SIRT1 and extracellular matrix (ECM) proteins such as collagen and elastin. In addition it significantly inhibited pro-inflammatory mediators (IL-1A, IL-6, IL-8) and biomarkers of skin aging, such as transforming growth factor beta 1 (TGFB1), transforming growth factor beta receptor 2 (TGFBR2), tumor necrosis factor receptor 1A (TNFRSF1) and S100 calcium-binding protein A8 (S100 A8) (Lephart and Andrus, 2017 ). The antioxidant property is an essential aspect of the protective effect of resveratrol.…”

Section: Grape Seed Polyphenolsmentioning

confidence: 99%

“…To improve its efficacy for cosmetic and medical applications, multiple studies have been conducted to develop resveratrol analogs that are more stable and more biologically active than the natural form. There is evidence that some of the analogs have great potential to be used for topical applications (Sirerol et al, 2015 ), especially considering that some were found to display increased potency and longer half-life compared to resveratrol (Lephart and Andrus, 2017 ). It is important that future studies determine how chemical modifications to resveratrol impact its beneficial effects in topical application and perhaps, even its bioavailability after oral ingestion.…”

Section: Grape Seed Polyphenolsmentioning

confidence: 99%

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Natural Antioxidants: Multiple Mechanisms to Protect Skin From Solar Radiation

et al. 2018

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Human skin exposed to solar ultraviolet radiation (UVR) results in a dramatic increase in the production of reactive oxygen species (ROS). The sudden increase in ROS shifts the natural balance toward a pro-oxidative state, resulting in oxidative stress. The detrimental effects of oxidative stress occur through multiple mechanisms that involve alterations to proteins and lipids, induction of inflammation, immunosuppression, DNA damage, and activation of signaling pathways that affect gene transcription, cell cycle, proliferation, and apoptosis. All of these alterations promote carcinogenesis and therefore, regulation of ROS levels is critical to the maintenance of normal skin homeostasis. Several botanical products have been found to exhibit potent antioxidant capacity and the ability to counteract UV-induced insults to the skin. These natural products exert their beneficial effects through multiple pathways, including some known to be negatively affected by solar UVR. Aging of the skin is also accelerated by UVR exposure, in particular UVA rays that penetrate deep into the epidermis and the dermis where it causes the degradation of collagen and elastin fibers via oxidative stress and activation of matrix metalloproteinases (MMPs). Because natural compounds are capable of attenuating some of the UV-induced aging effects in the skin, increased attention has been generated in the area of cosmetic sciences. The focus of this review is to cover the most prominent phytoproducts with potential to mitigate the deleterious effects of solar UVR and suitability for use in topical application.

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Section: Grape Seed Polyphenolsmentioning

confidence: 99%

Section: Grape Seed Polyphenolsmentioning

confidence: 99%

Natural Antioxidants: Multiple Mechanisms to Protect Skin From Solar Radiation

et al. 2018

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“…Both ethanol and DMSO are well-recognized transepidermal penetration enhancers for a variety of active principles in solution [ 9 , 10 , 45 ]. Since long-term application of organic solvents on the skin cannot be feasible in humans, vehicle formulations suitable for skin delivery of resveratrol [ 46 , 47 , 48 ] or quercetin [ 49 , 50 ], or chemical modifications facilitating their transcutaneous penetration [ 51 , 52 ] are under active development. Our data emphasize the potential effectiveness of resveratrol and quercetin in the prevention of type I IFN-driven pro-inflammatory circuits in the skin.…”

Section: Discussionmentioning

confidence: 99%

Topical Plant Polyphenols Prevent Type I Interferon Signaling in the Skin and Suppress Contact Hypersensitivity

Carbone

Lulli

Passarelli

et al. 2018

IJMS

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Human keratinocytes were recently shown to respond to anti-EGFR (epidermal growth factor receptor) drugs with activation of an interferon-κ-driven autocrine loop, leading to enhanced expression of innate antiviral effectors and of the pro-inflammatory chemokines CXCL10 (C-X-C motif chemokine 10) and CCL2 (C-C motif ligand 2). Here we showed active type I interferon signaling in the skin lesions of cancer patients undergoing treatment with the anti-EGFR drug cetuximab. Strong nuclear positivity for Interferon Regulatory Factor 1 and phosphorylated Signal Transducer and Activator of Transcription 1, enhanced interferon-κ expression and CXCL10 was associated to the epidermal compartment. Notably, 50 micromolar resveratrol and quercetin fully suppressed the low constitutive levels of type I interferon signaling and prevented its activation by the anti-EGFR cetuximab or gefitinib in cultured keratinocytes. In sensitized mice undergoing DNFB (2,4-dinitro-1-fluorobenzene)-induced contact hypersensitivity, local administration of gefitinib prior to elicitation further amplified hapten-induced type I interferon activation, tissue edema, and infiltration by T cells, whereas resveratrol or quercetin suppressed this inflammatory cascade. Overall, these data suggest that topical application of resveratrol or quercetin could be potentially effective in preventing pathological conditions due to overactivation of type I IFN (interferon)-driven circuits in the skin, including the inflammatory manifestations of anti-EGFR drug-induced skin-targeted toxicity.

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“…However, as skin’s metabolism remains relevant, the use of RSV prodrugs for skin diseases or for aesthetic indications (e.g., anti-aging and skincare) could have some advantages. For these reasons, the interest in using RSV prodrugs for dermal applications has been growing significantly (Table 7) [156,157,158,159].…”

Section: Prodrugsmentioning

confidence: 99%

Strategies to Improve Resveratrol Systemic and Topical Bioavailability: An Update

et al. 2019

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In recent years, a great deal of attention has been paid to natural compounds due to their many biological effects. Polyphenols are a class of plant derivatives that have been widely investigated for preventing and treating many oxidative stress-related pathological conditions, such as neurodegenerative and cardiovascular diseases, cancer, diabetes mellitus and inflammation. Among these polyphenols, resveratrol (RSV) has attracted considerable interest owing to its high antioxidant and free radical scavenging activities. However, the poor water solubility and rapid metabolism of RSV lead to low bioavailability, thus limiting its clinical efficacy. After discussing the main biochemical mechanisms involved in RSV biological activities, this review will focus on the strategies attempted to improve RSV effectiveness, both for systemic and for topical administration. In particular, technological approaches involving RSV incorporation into different delivery systems such as liposomes, polymeric and lipid nanoparticles, microemulsions and cyclodextrins will be illustrated, highlighting their potential clinical applications. In addition, chemical modifications of this antioxidant aimed at improving its physicochemical properties will be described along with the results of in vitro and in vivo studies.

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Human skin gene expression: Natural (trans) resveratrol versus five resveratrol analogs for dermal applications

Cited by 16 publications

References 44 publications

Natural Antioxidants: Multiple Mechanisms to Protect Skin From Solar Radiation

Natural Antioxidants: Multiple Mechanisms to Protect Skin From Solar Radiation

Topical Plant Polyphenols Prevent Type I Interferon Signaling in the Skin and Suppress Contact Hypersensitivity

Strategies to Improve Resveratrol Systemic and Topical Bioavailability: An Update

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