Sirtuins in wound healing

Abstract

Sirtuins (SIRTs) are initially recognized as NAD + -dependent histone deacetylase. SIRTs attract attention for their role as calorie restriction-induced "longevity proteins" to be expected to extend human life span and to promote health. As advancing studies, SIRTs have been recognized as cell signaling regulators which contribute to anti-inflammation, cell differentiation and so on. Therefore, SIRTs are supposed to affect wound healing which is comprised highly orchestrated complex four phases: hemostasis, inflammation, tissue formation and tissue remodeling. This review highlights the roles of SIRTs in wound healing process and provides a foundation and impetus for future basic and clinical research.

Ganoderma lucidumas a cosmeceutical: Antiradical potential and inhibitory effect on hyperpigmentation and skin extracellular matrix degradation enzymes

“…The ABTS and DPPH assays are typically classified as SET reactions, but these two indicator radicals may in fact be neutralized either by direct reduction via electron transfers or by radical quenching via the HAT mechanism [35]. Furthermore, polyphenolics can modulate the activity of nuclear factor kappa B (NF-κB) or sirtuin 1 (SIRT1), thus exerting protective effects [6,36]. SIRT1 acts as a "rescue gene", capable of repairing damage caused by the action of free radicals and of preventing the premature death of cells [6].…”

“…SIRT1 acts as a "rescue gene", capable of repairing damage caused by the action of free radicals and of preventing the premature death of cells [6]. SIRT1 in the epidermis regulates cell migration, redox response, inflammation, epidermis re-epithelialization, and granulation formation, it and plays a crucial role in wound repair [36]. It is an important regulator of the keratinocyte differentiation pathway and a potential regulator of skin aging [37].…”