Resveratrol and derivatives for the prevention and treatment of cancer

Fulda, Simone

doi:10.1016/j.drudis.2010.07.005

Cited by 218 publications

(148 citation statements)

References 73 publications

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“…Its highest content is reported in the fresh root of the traditional Chinese medical plant Polygonum cuspidatum (8). Previous studies have shown that resveratrol has numerous biological properties, including anti-inflammatory, antioxidant and antitumorigenic effects (9)(10)(11). Our recent study also showed that Res can suppress PC cell migration, invasion, and the progression of the epithelial-to-mesenchymal transition through the inhibition of the PI-3K/Akt/NF-κB signaling pathway (12).…”

Section: Introductionmentioning

confidence: 88%

Effect of resveratrol on proliferation and apoptosis of human pancreatic cancer MIA PaCa-2 cells may involve inhibition of the Hedgehog signaling pathway

Qin

Dang

et al. 2014

Molecular Medicine Reports

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Abstract. We previously demonstrated that resveratrol (Res) regulates the expression of PKC α and δ, to eventually inhibit growth and induce apoptosis in human gastric cancer cells. In the present study, the effect of Res on the growth of human pancreatic cancer cells was investigated, to further unveil the underlying mechanism. The human pancreatic cancer cell line MIA PaCa-2 was treated with three different concentrations of Res. Cell proliferation was assessed by the MTT assay, and apoptosis was detected by flow cytometry. Reverse transcription-quantitative PCR (RT-qPCR) and western blot analysis were used to measure the mRNA and protein levels of the Hedgehog (Hh) signaling proteins Ihh, Ptch and Smo. Our results revealed that Res can inhibit the cell proliferative ability in a time-and dose-dependent manner. The number of formed colonies in the Res-and 5-Fu (positive control)-treated groups was decreased as compared to the negative control group. Res further induced apoptosis of MIA PaCa-2 cells in a dose-dependent manner. In addition, the levels of Ihh, Ptch and Smo were decreased by Res treatment. Our findings suggest that Res inhibits proliferation and induces apoptosis of MIA PaCa-2 pancreatic cancer cells in vitro, which may be related to its inhibitory effect on the Hh signaling pathway.

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Section: Introductionmentioning

confidence: 88%

Effect of resveratrol on proliferation and apoptosis of human pancreatic cancer MIA PaCa-2 cells may involve inhibition of the Hedgehog signaling pathway

Qin

Dang

et al. 2014

Molecular Medicine Reports

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“…Long-term basic and clinical studies have suggested that RES is an ideal alternative drug in the therapy of different diseases (Pervaiz & Holme 2009;Baur 2010;Fulda 2010). Recently, the anti-cancer activity of RES has been studied in various types of cancer, including myeloma, ovarian cancer, pancreatic cancer and breast cancer, via the regulation of multiple pathways (Sun et al 2006;Shankar et al 2011;Vergara et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Resveratrol suppresses the epithelial-to-mesenchymal transition in PC-3 cells by down-regulating the PI3K/AKT signaling pathway

Zhi

Tong

et al. 2016

Animal Cells and Systems

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Resveratrol possesses a wide spectrum of pharmacological properties and has been an ideal alternative drug for the treatment of different cancers, including prostate cancer. However, the mechanisms by which resveratrol inhibits the growth of prostate cancer are still not fully elucidated. To understand the effect of resveratrol on the apoptosis and the epithelial-tomesenchymal transition (EMT) of prostate cancer as well as its related mechanism, we investigated the potential use of resveratrol in PC-3 prostate cancer cells in vitro using real-time PCR, fluorescence-activated cell sorting, Western blotting, etc. Resveratrol suppresses the PC-3 prostate cancer cell growth and induces apoptosis. Resveratrol also influences the expression of EMT-related proteins (increased E-cadherin and decreased Vimentin expression). Finally, resveratrol also suppressed Akt phosphorylation in PC-3 cells. This study indicates that resveratrol may be a potential anti-cancer treatment for prostate cancer; moreover, it provides new evidence that resveratrol suppresses prostate cancer growth and metastasis.ARTICLE HISTORY

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“…An in vitro anticancer study showed that the inhibitory rate of RES SNEDDS-PSO against MCF-7 breast cancer cells was 2.03-and 1.24-fold that of RES SNEDDS-IP at a concentration of 12.5 and 25 µg/mL, respectively. This study demonstrated that the newly developed SNEDDS may be a prospective formulation in the functional food and clinical fields.Key words pomegranate seed oil; self-nanoemulsification; trans-resveratrol; anti-inflammation; anticancer activity trans-Resveratrol (RES), a natural component, possesses broad therapeutic activities in the treatment of cancer, 1,2) inflammation, 3,4) neurodegenerative disorders, 5) hyperlipemia, 6) and so on. 7) However, trans-resveratrol application in clinic is scare due to its poor water-solubility, short half-life of 109 min, 8) and undesirable oral bioavailability.…”

mentioning

confidence: 99%

“…Key words pomegranate seed oil; self-nanoemulsification; trans-resveratrol; anti-inflammation; anticancer activity trans-Resveratrol (RES), a natural component, possesses broad therapeutic activities in the treatment of cancer, 1,2) inflammation, 3,4) neurodegenerative disorders, 5) hyperlipemia, 6) and so on. 7) However, trans-resveratrol application in clinic is scare due to its poor water-solubility, short half-life of 109 min, 8) and undesirable oral bioavailability.…”

mentioning

confidence: 99%

Pomegranate Seed Oil Exerts Synergistic Effects with <i>trans</i>-Resveratrol in a Self-nanoemulsifying Drug Delivery System

Liu

Zhang

et al. 2015

Biological & Pharmaceutical Bulletin

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Pomegranate seed oil (PSO) has diverse bioactivities. It was hyphothesized that if PSO were employed to construct a trans-resveratrol-loaded self-nanoemulsifying drug delivery system (RES SNEDDS-PSO), not only could PSO serve as an oil phase but also exert synergistic effects with resveratrol to yield better therapeutic outcomes. In this study, we prepared RES SNEDDS-PSO for the first time to validate that hypothesis. The anti-inflammatory and anticancer activities of RES SNEDDS-PSO were compared with another SNEDDS composed of oil phase isopropyl palmitate (RES SNEDDS-IP). The results showed that upon exposure to a 10-fold amount of water, RES SNEDDS-PSO was converted into nanoemulsions with a mean size of 44 nm. Nanoemulsions enhanced the water solubility of resveratrol by 20-fold, significantly improved resveratrol stability in intestinal fluid, and slowed the decomposition of resveratrol in water by 1-fold. An in vivo anti-infection test showed that the degree of inflammatory swelling in mice given RES SNEDDS-PSO was only 60 and 76% that of the group fed with RES SNEDDS-IP at doses of 10 and 20 mg/kg, respectively. An in vitro anticancer study showed that the inhibitory rate of RES SNEDDS-PSO against MCF-7 breast cancer cells was 2.03-and 1.24-fold that of RES SNEDDS-IP at a concentration of 12.5 and 25 µg/mL, respectively. This study demonstrated that the newly developed SNEDDS may be a prospective formulation in the functional food and clinical fields.Key words pomegranate seed oil; self-nanoemulsification; trans-resveratrol; anti-inflammation; anticancer activity trans-Resveratrol (RES), a natural component, possesses broad therapeutic activities in the treatment of cancer, 1,2) inflammation, 3,4) neurodegenerative disorders, 5) hyperlipemia, 6) and so on. 7) However, trans-resveratrol application in clinic is scare due to its poor water-solubility, short half-life of 109 min, 8) and undesirable oral bioavailability. 9) In vivo, RES quickly conjugated with endogenous glucose acid or sulfuric acid at 3-position to convert into the metabolites, 3-monoglucuronide and 3-monosulfate.8) Strategies regarding innovative formulations have to be under consideration to overcome shortages of RES.Self-nanoemulsifying drug delivery system (SNEDDS) may be a promising vehicle to ameliorate oral bioavailability of RES. SNEDDS is a transparent, thermodynamically stable system, usually composed of oil, surfactant, and co-solvent. It rapidly forms oil in water (o/w) nanoemulsions when diluted with gastrointestinal (GI) fluid. 10) As SNEDDS has nano size and much larger surface area, it is able to notably enhance the dissolution of drug. High surface area of nanoemulsions also provides better interaction between drug and GI fluid, resulting in improved absorption as well as bioavailability.11) Long chain triglycerides, capryol 90, labrafac PG, and so on, are often employed as oil phases of SNEDDS.12) Though those oil phases are excellent candidates to produce SNEDDS in line with treatment requirements, owing to the lack of bi...

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Resveratrol and derivatives for the prevention and treatment of cancer

Cited by 218 publications

References 73 publications

Effect of resveratrol on proliferation and apoptosis of human pancreatic cancer MIA PaCa-2 cells may involve inhibition of the Hedgehog signaling pathway

Effect of resveratrol on proliferation and apoptosis of human pancreatic cancer MIA PaCa-2 cells may involve inhibition of the Hedgehog signaling pathway

Resveratrol suppresses the epithelial-to-mesenchymal transition in PC-3 cells by down-regulating the PI3K/AKT signaling pathway

Pomegranate Seed Oil Exerts Synergistic Effects with <i>trans</i>-Resveratrol in a Self-nanoemulsifying Drug Delivery System

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