Resveratrol suppresses the epithelial-to-mesenchymal transition in PC-3 cells by down-regulating the PI3K/AKT signaling pathway

Zhi, Wang; Wu, Longxiang; Tong, Shiyu; Hu, Xiheng; Zu, Xiongbing; Li, Yuan; He, Wei; Liu, Longfei; Chen, Minfeng; Qi, Lin

doi:10.1080/19768354.2016.1150344

Cited by 8 publications

(4 citation statements)

References 27 publications

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“…For this, they used Western blotting using real-time PCR, and fluorescence-activated cell sorting etc. As per their results, resveratrol modulates EMT and apoptosis through PI3K/Akt pathway in prostate cancer (Wang et al, 2016 ). As per studies carried out by Aziz et al resveratrol inhibited the activation of PI3K/Akt.…”

Section: Resveratrolmentioning

confidence: 74%

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Phytochemicals and PI3K Inhibitors in Cancer—An Insight

et al. 2017

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In today's world of modern medicine and novel therapies, cancer still remains to be one of the prime contributor to the death of people worldwide. The modern therapies improve condition of cancer patients and are effective in early stages of cancer but the advanced metastasized stage of cancer remains untreatable. Also most of the cancer therapies are expensive and are associated with adverse side effects. Thus, considering the current status of cancer treatment there is scope to search for efficient therapies which are cost-effective and are associated with lesser and milder side effects. Phytochemicals have been utilized for many decades to prevent and cure various ailments and current evidences indicate use of phytochemicals as an effective treatment for cancer. Hyperactivation of phosphoinositide 3-kinase (PI3K) signaling cascades is a common phenomenon in most types of cancers. Thus, natural substances targeting PI3K pathway can be of great therapeutic potential in the treatment of cancer patients. This chapter summarizes the updated research on plant-derived substances targeting PI3K pathway and the current status of their preclinical studies and clinical trials.

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Section: Resveratrolmentioning

confidence: 74%

“…Wang et al ( 2016 ) evaluated Diallyl trisulfide (DATS) induced apoptosis in MG63 and MNNG/HOS cell lines. The cells were evaluated with various concentration of DATS for 48 h, whereas in some groups the cell lines were previously treated with N-acetylcysteine (NAC) and then co-treated with DATS.…”

Section: Diallyl Trisulfidementioning

confidence: 99%

Phytochemicals and PI3K Inhibitors in Cancer—An Insight

et al. 2017

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“…In studies about other cancers, it was shown that resveratrol could also inhibit the PI3K/Akt signaling pathway by up-regulating BMP7, thereby reducing the phosphorylation level of tumor suppressor genes and taking an anti-colon cancer effect (Zeng et al, 2017). Resveratrol can also inhibit the transformation of prostate cancer epithelial cells into mesenchymal cells (Wang et al, 2016). Some studies reported that resveratrol affected the proliferation and apoptosis of leukemia cells by regulating the PTEN/PI3K/AKT pathway (Meng et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Effects of polydatin on the proliferation, migration, and invasion of ovarian cancer

Zhang¹

2019

Biocell

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To investigate the effects of polydatin on the proliferation, migration, and invasion of ovarian cancer, the change of proliferative ability, migration ability, and invasive ability of human ovarian cancer cell OVCAR-3, A2780, and HO-8910 was detected by using polydatin and up-regulating PI3K. The anticancer activity and mechanism of polydatin in ovarian cancer were analyzed. Polydatin could effectively inhibit the proliferation, migration, and invasion of OVCAR-3, A2780, and HO-8910, and inhibit the expression of PI3K protein. After the expression level of PI3K protein was up-regulated, the inhibitory effect of polydatin on the proliferative ability, migration ability, and invasive ability of OVCAR-3, A2780, and HO-8910 significantly decreased, suggesting that PI3K was the target of polydatin. Therefore, we concluded that polydatin could inhibit the proliferation, migration, and invasion of ovarian cancer cells by inhibiting the expression of PI3K protein, which provides an experimental basis for polydatin in the treatment of ovarian cancer.

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“…Numerous molecular targets of resveratrol were reported, most important follow. Resveratrol activates AMPK [ 119 , 120 ]; downregulates NF-κB [ 121 , 122 ] thus impacting numerous cellular processes, particularly inflammatory responses, cellular growth, and apoptosis [ 123 , 124 ]; and downregulates PI3K/Akt and mTOR pathway [ 125 , 126 ], involved in regulating a variety of processes including insulin signaling, cell proliferation, and survival [ 127 ]. Resveratrol can modulate mitochondrial calcium, increase the efficacy of chemotherapeutic agents, target cancer stem cells, alleviate inflammation associated with tumors, and promote the elimination of impaired mitochondria through mitophagy [ 128 , 129 ].…”

Section: Senotherapeuticsmentioning

confidence: 99%

Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care—clinically relevant 3PM innovation

Golubnitschaja,

Kapinova,

Sargheini

et al. 2024

EPMA Journal

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Despite their subordination in humans, to a great extent, mitochondria maintain their independent status but tightly cooperate with the “host” on protecting the joint life quality and minimizing health risks. Under oxidative stress conditions, healthy mitochondria promptly increase mitophagy level to remove damaged “fellows” rejuvenating the mitochondrial population and sending fragments of mtDNA as SOS signals to all systems in the human body. As long as metabolic pathways are under systemic control and well-concerted together, adaptive mechanisms become triggered increasing systemic protection, activating antioxidant defense and repair machinery. Contextually, all attributes of mitochondrial patho-/physiology are instrumental for predictive medical approach and cost-effective treatments tailored to individualized patient profiles in primary (to protect vulnerable individuals again the health-to-disease transition) and secondary (to protect affected individuals again disease progression) care. Nutraceuticals are naturally occurring bioactive compounds demonstrating health-promoting, illness-preventing, and other health-related benefits. Keeping in mind health-promoting properties of nutraceuticals along with their great therapeutic potential and safety profile, there is a permanently growing demand on the application of mitochondria-relevant nutraceuticals. Application of nutraceuticals is beneficial only if meeting needs at individual level. Therefore, health risk assessment and creation of individualized patient profiles are of pivotal importance followed by adapted nutraceutical sets meeting individual needs. Based on the scientific evidence available for mitochondria-relevant nutraceuticals, this article presents examples of frequent medical conditions, which require protective measures targeted on mitochondria as a holistic approach following advanced concepts of predictive, preventive, and personalized medicine (PPPM/3PM) in primary and secondary care.

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Resveratrol suppresses the epithelial-to-mesenchymal transition in PC-3 cells by down-regulating the PI3K/AKT signaling pathway

Cited by 8 publications

References 27 publications

Phytochemicals and PI3K Inhibitors in Cancer—An Insight

Phytochemicals and PI3K Inhibitors in Cancer—An Insight

Effects of polydatin on the proliferation, migration, and invasion of ovarian cancer

Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care—clinically relevant 3PM innovation

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