Resveratrol ameliorates metabolic disorders and muscle wasting in streptozotocin-induced diabetic rats

Abstract

Diabetes mellitus (DM) is characterized by dysregulated energy metabolism. Resveratrol (RSV) has been shown to ameliorate hyperglycemia and hyperlipidemia in diabetic animals. However, its overall in vivo effects on energy metabolism and the underlying mechanism require further investigation. In the present study, electrospray ionization-tandem mass spectrometry was employed to characterize the urine and plasma metabolomes of control, streptozotocin-induced DM and RSV-treated DM rats. Using principal component analysis (PCA) and heat map analysis, we discovered significant differences among control and experimental groups. RSV treatment significantly reduced the metabolic abnormalities in DM rats. Compared with the age-matched control rats, the level of carnitine was lower, and the levels of acetylcarnitine and butyrylcarnitine were higher in the urine and plasma of DM rats. RSV treatment ameliorated the deranged carnitine metabolism in DM rats. In addition, RSV treatment attenuated the diabetic ketoacidosis and muscle protein degradation, as evidenced from the attenuation of elevated urinary methyl-histidine and plasma branched-chain amino acids levels in DM rats. The beneficial effects of RSV in DM rats were correlated with activation of hepatic AMP-activated protein kinase and SIRT1 expression, increase of hepatic and muscular mitochondrial biogenesis and inhibition of muscle NF-κB activities. We concluded that RSV possesses multiple beneficial metabolic effects in insulin-deficient DM rats, particularly in improving energy metabolism and reducing protein wasting.

Sirt1-Independent Rescue of Muscle Regeneration by Resveratrol in Type I Diabetes

“…In this regard, RSV was delivered systemically to live animals and thus its positive effects on muscle stem cells could be indirect, e.g. via the global improvement in energy metabolism and reduced protein degradation, which have been reported in a rat STZ model [28]. Regardless of a precise molecular mechanism, from a clinical perspective this work uncovers a novel strategy for improving the regenerative performance of organ stem cells in type I diabetes.…”

Resveratrol shows neuronal and vascular-protective effects in older, obese, streptozotocin-induced diabetic rats

“…These similarities also mean that the lack of improvement in cardiac function and glucose levels observed in the STZ + Res animals was not so unexpected. Ultimately, there is insufficient evidence to fully support the viability of resveratrol as a nutritional supplement to improve metabolic health (56)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66) .…”

Neurodegeneration in Streptozotocin-Induced Diabetic Rats Is Attenuated by Treatment with Resveratrol

“…Rsv has been reported to possess a host of biological effects due probably to its antioxidant nature [22,23,24] and its effect on energy metabolism. Studies with non-neural organs such as rat heart and kidney have demonstrated the ability of Rsv to reduce ischemia/reperfusion injuries [25,26].…”