Sirt1-Independent Rescue of Muscle Regeneration by Resveratrol in Type I Diabetes

Conboy, Jaemin Jeong Michael J.

doi:10.4172/2155-6156.1000289

Cited by 3 publications

(4 citation statements)

References 34 publications

(50 reference statements)

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“…In line with this, treatment with resveratrol during recovery for two weeks of aged rats exposed to tail suspension also induced moderate therapeutic benefits as identified by muscle mass recovery and increased size of the fast-twitch fibers of limb muscles, probably resulting from the attenuation of apoptosis [25]. Another study [55] also demonstrated that the beneficial effects induced by resveratrol on the limb muscles of type I diabetic mice was not dependent on sirtuin-1 activity. In that investigation, mitochondrial membrane potential was restored in muscle fibers without the interference of sirtuin-1 activity in the mouse muscles [55].…”

Section: Discussionsupporting

confidence: 52%

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Satellite Cells and Markers of Muscle Regeneration during Unloading and Reloading: Effects of Treatment with Resveratrol and Curcumin

et al. 2020

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We hypothesized that treatment with pharmacological agents known to increase sirtuin-1 activity (resveratrol and curcumin) may enhance muscle regeneration. In limb muscles of mice (C57BL/6J, 10 weeks) exposed to reloading for seven days following a seven-day period of hindlimb immobilization with/without curcumin or resveratrol treatment, progenitor muscle cell numbers (FACS), satellite cell subtypes (histology), early and late muscle regeneration markers, phenotype and morphometry, sirtuin-1 activity and content, and muscle function were assessed. Treatment with either resveratrol or curcumin in immobilized muscles elicited a significant improvement in numbers of progenitor, activated, quiescent, and total counts of muscle satellite cells, compared to non-treated animals. Treatment with either resveratrol or curcumin in reloaded muscles compared to non-treated mice induced a significant improvement in the CSA of both hybrid (curcumin) and fast-twitch fibers (resveratrol), sirtuin-1 activity (curcumin), sirtuin-1 content (resveratrol), and counts of progenitor muscle cells (resveratrol). Treatment with the pharmacological agents resveratrol and curcumin enhanced the numbers of satellite cells (muscle progenitor, quiescent, activated, and total satellite cells) in the unloaded limb muscles but not in the reloaded muscles. These findings have potential clinical implications as treatment with these phenolic compounds would predominantly be indicated during disuse muscle atrophy to enhance the muscle regeneration process.

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Section: Discussionsupporting

confidence: 52%

“…Another study [55] also demonstrated that the beneficial effects induced by resveratrol on the limb muscles of type I diabetic mice was not dependent on sirtuin-1 activity. In that investigation, mitochondrial membrane potential was restored in muscle fibers without the interference of sirtuin-1 activity in the mouse muscles [55].…”

Section: Discussionmentioning

confidence: 93%

Satellite Cells and Markers of Muscle Regeneration during Unloading and Reloading: Effects of Treatment with Resveratrol and Curcumin

et al. 2020

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“…However, in the gastrocnemius of mice bearing the two conditions, especially in LC 30-days+15-day I, a significant decline in the number of activated satellite cells was observed. Previous investigations also showed a rise in the number of muscle precursor cells in atrophying muscles, which was confirmed using electron microscopy [26,27], and in models of cancer cachexia [37,44,45]. Nonetheless, the numbers of activated satellite cells and myoblasts (Pax-7+/MyoD+ cells) were substantially reduced in the muscles of the cachectic animals exposed to 15 days of unloading, while the counts of quiescent satellite cells were similar to those detected in the gastrocnemius of either cancer cachexia or unloading conditions, separately.…”

Section: Discussionmentioning

confidence: 55%

Prolonged Immobilization Exacerbates the Loss of Muscle Mass and Function Induced by Cancer-Associated Cachexia through Enhanced Proteolysis in Mice

Mañas-García

Penedo-Vázquez

López-Postigo

et al. 2020

IJMS

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We hypothesized that in mice with lung cancer (LC)-induced cachexia, periods of immobilization of the hindlimb (7 and 15 days) may further aggravate the process of muscle mass loss and function. Mice were divided into seven groups (n = 10/group): (1) non-immobilized control mice, (2) 7-day unloaded mice (7-day I), (3) 15-day unloaded mice (15-day I), (4) 21-day LC-cachexia group (LC 21-days), (5) 30-day LC-cachexia group (LC 30-days), (6) 21-day LC-cachexia group besides 7 days of unloading (LC 21-days + 7-day I), (7) 30-day LC-cachexia group besides 15 days of unloading (LC 30-days + 15-day I). Physiological parameters, body weight, muscle and tumor weights, phenotype and morphometry, muscle damage (including troponin I), proteolytic and autophagy markers, and muscle regeneration markers were identified in gastrocnemius muscle. In LC-induced cachexia mice exposed to hindlimb unloading, gastrocnemius weight, limb strength, fast-twitch myofiber cross-sectional area, and muscle regeneration markers significantly decreased, while tumor weight and area, muscle damage (troponin), and proteolytic and autophagy markers increased. In gastrocnemius of cancer-cachectic mice exposed to unloading, severe muscle atrophy and impaired function was observed along with increased muscle proteolysis and autophagy, muscle damage, and impaired muscle regeneration.

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“…The effects of RSV on apoptosis in the kidney [95], heart [52], brain [96], testes [97], retina [48], and muscle [98] in diabetic animals have been reported. In these studies, RSV was shown to significantly reduce the apoptotic index coupled with a reduction in the levels of proapoptotic proteins in diabetic tissues.…”

Section: Mechanisms Of Protection Of Resveratrol In Diabetes Mellimentioning

confidence: 99%

Antidiabetic Effects of Resveratrol: The Way Forward in Its Clinical Utility

Oyenihi

Adeyanju

et al. 2016

Journal of Diabetes Research

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Despite recent advances in the understanding and management of diabetes mellitus, the prevalence of the disease is increasing unabatedly with resulting disabling and life-reducing consequences to the global human population. The limitations and side effects associated with current antidiabetic therapies have necessitated the search for novel therapeutic agents. Due to the multipathogenicity of diabetes mellitus, plant-derived compounds with proven multiple pharmacological actions have been postulated to “hold the key” in the search for an affordable, efficacious, and safer therapeutic agent in the treatment of the disease and associated complications. Resveratrol, a phytoalexin present in few plant species, has demonstrated beneficial antidiabetic effects in animals and humans through diverse mechanisms and multiple molecular targets. However, despite the enthusiasm and widespread successes achieved with the use of resveratrol in animal models of diabetes mellitus, there are extremely limited clinical data to confirm the antidiabetic qualities of resveratrol. This review presents an update on the mechanisms of action and protection of resveratrol in diabetes mellitus, highlights challenges in its clinical utility, and suggests the way forward in translating the promising preclinical data to a possible antidiabetic drug in the near future.

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Sirt1-Independent Rescue of Muscle Regeneration by Resveratrol in Type I Diabetes

Cited by 3 publications

References 34 publications

Satellite Cells and Markers of Muscle Regeneration during Unloading and Reloading: Effects of Treatment with Resveratrol and Curcumin

Satellite Cells and Markers of Muscle Regeneration during Unloading and Reloading: Effects of Treatment with Resveratrol and Curcumin

Prolonged Immobilization Exacerbates the Loss of Muscle Mass and Function Induced by Cancer-Associated Cachexia through Enhanced Proteolysis in Mice

Antidiabetic Effects of Resveratrol: The Way Forward in Its Clinical Utility

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