Results of the Thoracoscopic Radiofrequency Epicardial Ablation with a Bipolar Electrode During Longstanding Persistent form of Atrial Fibrillation

Abstract

Thoracoscopic ablation using the ‘box lesion’ technique was performed using a bipolar radio frequency clamp. A total of 48 patients, including 38 men and 10 women, mean age 58 years (range 33 74). The mean duration of AF was 4 yrs (range 1.5 months 21), the mean size of the atrium 4.15 ± 0.9 cm (2.9-8.8 cm), mean LVEF was 57.7% (39 -73%). Mitral regurgitation of 1-2 degrees was present in 14 patients, EDV LV 147.7 ml (81-224). Primary catheter ablation was performed in 22 patients, where 5 of them (22,7%) were performed repeatedly. Resection of the left atrial appendage (LAA) during the operation was performed in 44 patients (91%). Input and output block was achieved in all patients. In the postoperative period, all patients were administered supporting antiarrhythmic therapy with amiodarone and β-blockers, anticoagulant therapy with warfarin or PLA for 6-12 months. The effectiveness of treatment was monitored by a cardiomonitor Reveal XT in the period 1, 3, 6, 12, 24 months after surgery, the mean follow-up length was 498 ± 19 days. Sinus rhythm was restored during surgery in all patients and remained until discharge.

A comparative study of valaciclovir, valganciclovir, and artesunate efficacy in reactivated HHV‐6 and HHV‐7 infections associated with chronic fatigue syndrome/myalgic encephalomyelitis

“…Numerous controlled clinical trials indicate herpesvirus reactivation in patients with CFS, confirmed by positive leukocyte PCR results 3,7,8,24–28 . Another group of studies reports an abnormal immune response to activating proteins of the virus.…”

“…23 Numerous controlled clinical trials indicate herpesvirus reactivation in patients with CFS, confirmed by positive leukocyte PCR results. 3,7,8,[24][25][26][27][28] Another group of studies reports an abnormal immune response to activating proteins of the virus. They are associated with the active reproduction of viral particles in the human body (IgM, IgG to early antigen or p41/38 and IgG to dUTP HHV-6).…”

Cardiorespiratory System in the Context of Regular Exercise in Kayaking

“…The positive effect of running on the function of joints is possible only if adequate (not exceeding the capabilities of the motor apparatus) loads are used, and their gradual increase during exercise. The modern experience and development of the rowing and canoeing is characterised by a constant search for more effective means, methods, and organisational forms of training sports reserves (Tuleutaev et al, 2020;Yessentayeva et al, 2021). The main role in the long-term training of athletes is played by the stage of sports improvement.…”

The efficacy of combined immunotherapy with Propes and Inflamafertin in adult patients with genetic deficiency of the folate cycle and selective deficiency of NK and NKT cells

“…Based on the experience of usage of another highly active proinflammatory immunomodulatory agent—recombinant interleukin 2—therapeutic immune activation may lead to an undesirable increase in the risk of some autoimmune complications due to impaired immune tolerance to autoantigens [22]. Therefore, the combination of the immunoactivating drug (Propes) with the anti‐inflammatory tolerogenic immunotropic agent (Inflamafertin) seems to be a reliable guarantee of achieving a safe immunomodulatory effect of the applied immunotherapeutic interventions in GDFC patients with selective deficiency of NK and/or NKT cells [23, 24].…”