Abstract:Введение. Язвенный колит -хроническое рецидивирующее системное воспалительное заболевание с преимущественным поражением слизистой оболочки толстой кишки. Каждый год регистрируется до 20 новых случаев заболевания на 100 тыс. населения, в основном среди лиц трудоспособного возраста. По мнению ряда авторов, в патогенезе развития и возникновения заболевания одну из ведущих причин играет изменение в составе микрофлоры толстой кишки, а также продукты их метаболизма, воздействующие на энтериновую систему и моторику к… Show more
“…В некоторых исследованиях повышенный уровень бактерии наблюдался при наличии атеросклеротических повреждениях, что служит пусковым фактором развития сердечно-сосудистых заболеваний. Также повышенное значение отмечалось у лиц, страдающих избыточной массой тела, сахарным диабетом 2 типа [35,36,37].…”
Section: Features Of Intestinal Microbiota Diversity In Elderly Patie...unclassified
Background: Currently, the proportion of elderly patients is increasing all over the world (more than 20% of patients over the age of 60 in the Russian Federation), most of whom suffer from chronic non-communicable diseases, including metabolic disorders (type 2 diabetes mellitus, obesity, dyslipidemia). Laboratory diagnostic methods (glucose tolerance test, determination of glucose, glycated hemoglobin, total cholesterol, low-and high-density lipoproteins, atherogenic coefficient), widely used by specialists in various fields, are able to make a diagnosis in a timely manner. There are many theories explaining the development of the pathological process in metabolic disorders. In atherosclerotic vascular lesions, endothelial dysfunction and oxidative stress can play an important role. In addition, one of the new mechanisms for the development of pathological inflammation may be the formation of the intestinal microbiota with a predominance of a cluster of bacteria that produce
“…В некоторых исследованиях повышенный уровень бактерии наблюдался при наличии атеросклеротических повреждениях, что служит пусковым фактором развития сердечно-сосудистых заболеваний. Также повышенное значение отмечалось у лиц, страдающих избыточной массой тела, сахарным диабетом 2 типа [35,36,37].…”
Section: Features Of Intestinal Microbiota Diversity In Elderly Patie...unclassified
Background: Currently, the proportion of elderly patients is increasing all over the world (more than 20% of patients over the age of 60 in the Russian Federation), most of whom suffer from chronic non-communicable diseases, including metabolic disorders (type 2 diabetes mellitus, obesity, dyslipidemia). Laboratory diagnostic methods (glucose tolerance test, determination of glucose, glycated hemoglobin, total cholesterol, low-and high-density lipoproteins, atherogenic coefficient), widely used by specialists in various fields, are able to make a diagnosis in a timely manner. There are many theories explaining the development of the pathological process in metabolic disorders. In atherosclerotic vascular lesions, endothelial dysfunction and oxidative stress can play an important role. In addition, one of the new mechanisms for the development of pathological inflammation may be the formation of the intestinal microbiota with a predominance of a cluster of bacteria that produce
Relevance. Pathology of non-infectious genesis is currently playing a leading role in the structure of overall morbidity of the population. The incidence of inflammatory bowel diseases increases all over the world. The severity of inflammatory bowel diseases complicates the presence of comorbid pathology, metabolic disorders, which lead to disability and the risk of premature death. Currently available diagnostic measures allow to detect disorders at the stage of clinical manifestations. There are several factors causing the development of pathological changes at the early stage including the peculiarities of intestinal microbiome formation and the predominance of certain microorganism clusters with the subsequent formation of a biotype, which may allow diagnosing the disease at a latent stage.Aim: To evaluate the role of the intestinal microbiota in the formation of inflammatory bowel diseases and metabolic disorders according to the data of national and foreign literature.Material and Methods. The review of literature on this topic was carried out based on the analysis of data obtained from the publications indexed in PubMed, Web of Science, Scopus, Google Academy, and eLibrary.ru databases over the past 10 years.Results. Data on the role of intestinal microbiota in the development of changes in patients with inflammatory bowel diseases and metabolic disorders (obesity, impaired glucose tolerance, and diabetes mellitus) were revealed. New potential mechanisms for the development of type 2 diabetes mellitus were identified, and the features of the generic composition of the flora in patients with comorbid pathology were described.Conclusion. The obtained results suggest that further research is required to improve understanding of this pathology and to create the methods for correcting the gut microbiota in case of abnormal findings.
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