Results of Pneumonectomy for Non-Small Cell Lung Cancer

Mizushima, Yutaka; Noto, Hirofumi; Kusajima, Yoshinori; Yamashita, Ryohei; Sugiyama, Shigeki; Kashii, Tatsuhiko; Kobayashi, Masashi

doi:10.3109/02841869709001305

Cited by 6 publications

(5 citation statements)

References 21 publications

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“…Of our patients with detected N2 disease, 60% had a squamous-cell carcinoma and 32% had an adenocarcinoma. This finding is contrary to some reports indicating that squamous cell carcinomas have a lower biological potential for mediastinal lymph node metastasis [6].…”

Section: Discussioncontrasting

confidence: 99%

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Pneumonectomy; a risky type of resection in non-small cell lung cancer: survival and mortality analysis

Yazgan¹,

Gürsoy²,

Üçvet³

et al. 2018

Curr Thorac Surg

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Background: This study aims to evaluate the mortality and survival rates of patients undergoing pneumonectomy due to primary non-small cell lung cancer (NSCLC) and to identify the factors which affect these variables. Materials and Methods: This retrospective single center cohort study included a total of 250 patients who underwent pneumonectomy due to NSCLC between January 2007 and July 2015. 30-and 90-day mortality rates and survival rates of the patients were analyzed. The factors which affected survival and mortality were evaluated. Results: The mean age was 59 (range: 35 to 77) years. The median survival was 48.1 months (95% C. I. 30.6-65.6 months) and five-year survival rate was 45.6%. The 30-and 90-day mortality rates were 6.4% and 7.6%, respectively. Age, nodal disease, and complete resection were factors to affect the survival (p = 0.002, p = 0.0001 and p = 0.017, respectively). Age was also effective on 30-and 90-day mortality (p = 0.004, RR: 3.3 and p = 0.006, RR: 2.5, respectively). The early rethoracotomy rate was 5.6% (n = 14) and the postoperative mortality rate in these patients was 28.6% (n = 4). Conclusions: Although implementation of pneumonectomy due to lung cancer seems fearful, the present study found lower survival rates only depending on advanced age and N2 disease. The high levels of 30-and 90-day mortality and the increased mortality after early rethoracotomy was associated with advanced age and comorbidity. In terms of postoperative mortality, the selection of eligible patients is important in elderly patients who are candidates of pneumonectomy due to lung cancer.

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Section: Discussioncontrasting

confidence: 99%

“…This is also supported by our patient group 80% of which consisted of N0 and N1 patients. Similar two series reported higher postoperative N2 disease rate as 26% and 41% [1,6]. Of our patients with detected N2 disease, 60% had a squamous-cell carcinoma and 32% had an adenocarcinoma.…”

Section: Discussionsupporting

confidence: 76%

Pneumonectomy; a risky type of resection in non-small cell lung cancer: survival and mortality analysis

Yazgan¹,

Gürsoy²,

Üçvet³

et al. 2018

Curr Thorac Surg

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“…A variety of antibody groups have been used to this end, such as cytokeratin subgroups related to normal constituents of epithelial cells in various organ systems 12 –14 and, in relation to the lung, proteins related to specific cellular functions in the lung such as surfactant 15 and TTF‐1 9 . However, these antibodies have only occasionally been assessed in relation to distinguishing between thymic and pulmonary neoplasms, 5 an area where difficulties in identifying the primary site may significantly change the prognosis, as well as the stage of the tumour and the likelihood of operability 16 –18 . The purpose of this study was to assess selected antibodies from the above groups, in conjunction with lymphocyte markers reported as being of value in resolving this differential diagnosis 5 , 19 …”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical markers in the differentiation of thymic and pulmonary neoplasms

et al. 2002

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“…Modern perioperative mortality following pneumonectomy varies greatly, ranging from 3.0 to 25% in published series. 8,10,18,19 Besides patient comorbidities and lung cancer extension, the volume of surgical cases, the specialization of the medical team, patient selection bias, and the definition of outcome may account for variations in both mortality and morbidity data. Better results are achieved with specialized thoracic surgeons (vs general surgeons) and in institutions with high caseloads.…”

Section: Operative Mortality and Cardiovascular Complicationsmentioning

confidence: 99%

Risk Factors for Early Mortality and Major Complications Following Pneumonectomy for Non-small Cell Carcinoma of the Lung

Licker¹,

Spiliopoulos

Frey

et al. 2002

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Results of Pneumonectomy for Non-Small Cell Lung Cancer

Cited by 6 publications

References 21 publications

Pneumonectomy; a risky type of resection in non-small cell lung cancer: survival and mortality analysis

Pneumonectomy; a risky type of resection in non-small cell lung cancer: survival and mortality analysis

Immunohistochemical markers in the differentiation of thymic and pulmonary neoplasms

Risk Factors for Early Mortality and Major Complications Following Pneumonectomy for Non-small Cell Carcinoma of the Lung

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