Pneumonectomy; a risky type of resection in non-small cell lung cancer: survival and mortality analysis

Yazgan, Serkan; Gürsoy, Soner; Üçvet, Ahmet; Samancılar, Özgür; Erbaycu, Ahmet Emin; Ünal, Mehmet; Yağcı, Tarık

doi:10.26663/cts.2019.00020

Cited by 3 publications

(1 citation statement)

References 14 publications

(27 reference statements)

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“…Despite advances in surgical techniques, pneumonectomy still has higher morbidity and mortality rates than other anatomic resections. As it is associated with higher morbidity and mortality, compared to other lung resections, the effect of pneumonectomy on long-term survival is still controversial (1).…”

Section: Introductionmentioning

confidence: 99%

Prognostic factors after pneumonectomy in non-small cell lung cancer

Aker¹,

Sezen²,

Doğru³

et al. 2022

acmr

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Background: This study aims to evaluate the factors affecting survival and mortality in patients who underwent pneumonectomy for non-small cell lung cancer. Methods:The study included 241 pneumonectomy patients. Demographic data, mortality, histopathological characteristics, tumor stages, and 5-year survival rates were analyzed. Results:The study included nine women (3.7%) and 232 men (96.3%). The patients' mean age was 58.4±8.0 (34-81) years. Fortyfive patients (18.7%) were 65 years of age or older, and 196 patients (81.3%) were less than 65 years of age. The 30-day postoperative mortality rate was 7.9% (n=19). The only factor affecting mortality was determined as age 65 and over (p = 0.012). The median survival time was 52 months, and the 5-year survival rate was 49.4%. In multivariate analysis, advanced age, pN2 status, not receiving neoadjuvant treatment, performing sampling lymph node dissection, and not receiving adjuvant treatment were poor prognostic factors. Conclusion:Age, pN2 status, neoadjuvant and adjuvant therapy, and lymph node dissection technique were determined as the most important prognostic factors affecting survival in patients who underwent pneumonectomy for non-small cell lung cancer. Age was the most important factor affecting mortality.

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Section: Introductionmentioning

confidence: 99%

Prognostic factors after pneumonectomy in non-small cell lung cancer

Aker¹,

Sezen²,

Doğru³

et al. 2022

acmr

View full text Add to dashboard Cite

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Evaluation of factors affecting morbidity and mortality in pneumonectomy patients

Doğru

Sezen

Aker

et al. 2020

Acta Chirurgica Belgica

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Pneumonectomy for primary lung cancer: contemporary outcomes, risk factors and model validation

Brunswicker

Taylor

Grant

et al. 2021

Interactive CardioVascular and Thoracic Surgery

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OBJECTIVES Despite the increased rate of adverse outcomes compared to lobectomy, for selected patients with lung cancer, pneumonectomy is considered the optimal treatment option. The objective of this study was to identify risk factors for mortality in patients undergoing pneumonectomy for primary lung cancer. METHODS Data from all patients undergoing pneumonectomy for primary lung cancer at 2 large thoracic surgical centres between 2012 and 2018 were analysed. Multivariable logistic and Cox regression analyses were used to identify risk factors associated with 90-day and 1-year mortality and reduced long-term survival, respectively. RESULTS The study included 256 patients. The mean age was 65.2 (standard deviation 9.4) years. In-hospital, 90-day and 1-year mortality were 6.3% (n = 16), 9.8% (n = 25) and 28.1% (n = 72), respectively. The median follow-up time was 31.5 months (interquartile range 9–58 months). Patients who underwent neoadjuvant therapy had a significantly increased risk of 90-day [odds ratio 6.451, 95% confidence interval (CI) 1.867–22.291, P = 0.003] and 1-year mortality (odds ratio 2.454, 95% CI 1.079–7.185, P = 0.044). Higher Performance Status score was associated with higher 1-year mortality (odds ratio 2.055, 95% CI 1.248–3.386, P = 0.005) and reduced overall survival (hazard ratio 1.449, 95% CI 1.086–1.934, P = 0.012). Advanced (stage III/IV) disease was associated with reduced overall survival (hazard ratio 1.433, 95% CI 1.019–2.016, P = 0.039). Validation of a pneumonectomy-specific risk model demonstrated inadequate model performance (area under the curve 0.54). CONCLUSIONS Pneumonectomy remains associated with a high rate of perioperative mortality. Neoadjuvant chemoradiotherapy, Performance Status score and advanced disease emerged as the key variables associated with adverse outcomes after pneumonectomy in our cohort.

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Pneumonectomy; a risky type of resection in non-small cell lung cancer: survival and mortality analysis

Cited by 3 publications

References 14 publications

Prognostic factors after pneumonectomy in non-small cell lung cancer

Prognostic factors after pneumonectomy in non-small cell lung cancer

Evaluation of factors affecting morbidity and mortality in pneumonectomy patients

Pneumonectomy for primary lung cancer: contemporary outcomes, risk factors and model validation

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