Evaluation of factors affecting morbidity and mortality in pneumonectomy patients

Doğru, Mustafa Vedat; Sezen, Celal Buğra; Aker, Cemal; Girgin, Oğuz; Kilimci, Umut; Erduhan, Semih; Metin, Muzaffer

doi:10.1080/00015458.2020.1753147

Cited by 10 publications

(14 citation statements)

References 26 publications

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“…In the present study, we analyzed the risk factors for postoperative complications in patients who underwent pulmonary resection for NSCLC. Several factors such as age, smoking history, Charlson comorbidity index, operative approach, and the type of operative procedure have been reported as risk factors for postoperative complications in NSCLC patients who had undergone pulmonary resection [ 5 , 20 , 21 ]. In the present study, although Charlson comorbidity index was not significant risk factor for postoperative complications, sex, coexistence of asthma, low FEV 1 %, and the type of operative procedure were significant risk factors for postoperative complications.…”

Section: Discussionmentioning

confidence: 99%

Individualization of risk factors for postoperative complication after lung cancer surgery: a retrospective study

et al. 2021

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Background The risk factors for postoperative complications after pulmonary resection in patients with non-small cell lung cancer (NSCLC) have not been elucidated. Methods Clinical data of 956 patients with NSCLC were analyzed. Patient factors such as sex, age, comorbidities, smoking history, respiratory function, and the lobe involved in lung cancer and operative factors such as operative approach and operative procedures were collected and analyzed. Results Male sex (odds ratio [OR]: 1.73, 95% confidence interval [CI]: 1.09–2.75, p = 0.01), coexistence of asthma (OR 2.68, 95% CI 1.19–6.02, p = 0.01), low percentage of forced expiratory volume in 1 s (FEV1) (OR 1.41, 95% CI 1.02–1.95, p = 0.03), and lobectomy or greater resection (OR 2.47, 95% CI 1.66–3.68, p < 0.01) were identified as significant risk factors for postoperative complications. Male sex (OR 1.98; 95% CI 1.03–3.81, p = 0.03) and complete video-assisted thoracic surgery and robot-assisted thoracic surgery (OR 1.64; 95% CI 1.09–2.45; p = 0.01) were identified as significant risk factors for postoperative air leakage. Coexistence of asthma (OR 9.97; 95% CI 3.66–27.38; p < 0.01) was identified as a significant risk factor for postoperative atelectasis or pneumonia. Lobectomy or greater resection (OR 19.71; 95% CI 2.70–143.57; p < 0.01) was identified as a significant risk factor for postoperative arrhythmia. Conclusion Male sex, coexistence of asthma, low percentage of FEV1, and operative procedure were significant risk factors for postoperative complications. Furthermore, risk factors varied according to postoperative complications.

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Section: Discussionmentioning

confidence: 99%

Individualization of risk factors for postoperative complication after lung cancer surgery: a retrospective study

et al. 2021

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“…In IT, combining RT and CHT increases the pCR, and relevant studies have shown that CHT has no negative impact on mortality and morbidity. [25][26][27] In the study of Galetta and Spaggiari, [25] induction CHT led to a significant increase in the morbidity rates. However, the mortality rates were acceptable, given that the patients had advanced tumors.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of prognostic factors in lung cancers with surgical complete response after induction treatment

Doğru¹,

Sezen²,

Aker³

et al. 2021

Turk Gogus Kalp Dama

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Background: This study aims to evaluate long-term results of induction treatment and to investigate prognostic factors affecting survival in non-small cell lung cancer patients with a pathological complete response. Methods: Between January 2010 and December 2017, a total of 39 patients (38 males, 1 female; mean age: 56.2±8.3 years; range, 38 to 77 years) having locally advanced (IIIA-IIIB) non-small cell lung cancer who were given induction treatment and underwent surgery after induction treatment and had a pathological complete response were retrospectively analyzed. Survival rates of the patients and prognostic factors of survival were analyzed. Results: Clinical staging before induction treatment revealed Stage IIB, IIIA, and IIIB disease in three (7.7%), 26 (66.7%), and 10 (25.6%) patients, respectively. The five-year overall survival rate was 61.2%, and the disease-free survival rate was 55.1%. In nine (23.1%) patients, local and distant recurrences were detected in the postoperative period. Conclusion: In patients with locally advanced non-small cell lung cancer undergoing surgery after induction treatment, the rates of pathological complete response are at considerable levels. In these patients, the five-year overall survival is quite satisfactory and the most important prognostic factor affecting overall survival is the presence of single-station N2.

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“…For stage I patients, it is controversial whether pneumonectomy should be indicated at this early stage; however, aggressive surgery, such as pneumonectomy, may be recommended in cases where cancerous cells invade the peri-bronchial lymphatic net. After a pneumonectomy, NSCLC patients have severely diminished lung function with a 30-day postoperative mortality rate of 4.0-6.5% [2,22]. Postoperative quality of life is even lower in female patients and after right-sided pneumonectomy [23].…”

Section: Non-small Cell Lung Cancermentioning

confidence: 99%

“…More preferable to pneumonectomies are lobectomies and segmentectomies due to lower peri-and postoperative risks. For pneumonectomy patients, the rate of postoperative complications is approximately 30-40% [1][2][3]. The 30-day postoperative mortality rate is ≈5% for non-small cell lung cancer (NSCLC) patients, with a 5-year survival rate of only 38% [4].…”

Section: Introductionmentioning

confidence: 99%

Drug Regimen for Patients after a Pneumonectomy

Kim

Priefer

2021

JoR

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Pneumonectomy is an entire lung removal and is indicated for both malignant and benign diseases. Due to its invasiveness and postoperative complications, pneumonectomy is still associated with high mortality and morbidity. Appropriate postoperative management is crucial in pneumonectomy patients to improve quality of life and overall survival rates. Diverse drug regimens are under development to be used in adjuvant chemotherapy or to improve respiratory health after a pneumonectomy. The most common causes for a pneumonectomy are non-small cell lung cancer, malignant pleural mesothelioma, and tuberculosis; thus, an appropriate drug regimen is necessary. The uncommon incidence of pneumonectomy cases remains the major obstacle in studies of postoperative drug regimens. As the majority of current studies include post-lobectomy and post-segmentectomy patients, it is highly recommended that further research of postoperative drug regimens be focused on post-pneumonectomy patients.

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Evaluation of factors affecting morbidity and mortality in pneumonectomy patients

Cited by 10 publications

References 26 publications

Individualization of risk factors for postoperative complication after lung cancer surgery: a retrospective study

Individualization of risk factors for postoperative complication after lung cancer surgery: a retrospective study

Evaluation of prognostic factors in lung cancers with surgical complete response after induction treatment

Drug Regimen for Patients after a Pneumonectomy

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