Resultados iniciales y seguimiento clínico a 6 meses tras el implante de un stent coronario recubierto de carburo de silicio

Mechanical stability, corrosion performance and bioresponse of amorphous diamond-like carbon for medical stents and guidewires

“…These may often provide inconclusive or even contradictory results across the test set. In-vivo evaluation has been more limited with examples of implantation into a number of animals [11,8,[15][16][17][18] that the results to date amount to a database of evidence for DLC biocompatibility rather than a systematic and conclusive investigation. It is important to state that biocompatibility is highly application-specific: some applications will require a non-adhesive surface while others will demand complete tissue integration using engineered bioactive, possibly nanostructured, material surfaces that can promote and stabilise cell attachment.…”

“…It is important to state that biocompatibility is highly application-specific: some applications will require a non-adhesive surface while others will demand complete tissue integration using engineered bioactive, possibly nanostructured, material surfaces that can promote and stabilise cell attachment. Proof of principle and approval is ultimately determined by clinical trials yet a conclusive outcome based on in-vitro and in-vivo testing is not guaranteed, as recent results on SiC may indicate [19,16,20]. Evidence from clinical trials provides limited feedback because neither the specific DLC properties nor the source of failure/success are sufficiently detailed, for commercial reasons and possibly because DLC is seen, among users, as a single rather than as a class of materials with widely differing properties.…”

Surface Modifications of Medical Grade Stainless Steel

“…In a study, heparin (HEP)-coated Ta stents and Au-coated stents induced less platelet activation and leukocyte-platelet aggregation [131]. In a clinical setting, MSS coated with hydrogen-rich amorphous silicon reduced thrombogenicity and improved biocompatibility [132]. In a study, "G" was developed on MSS using CVD and correlated with metallic Ni and Cr 3 C 2 phases on the surface, and was found to promote the adhesion and collagen secretion of mesenchymal stem cells [25].…”

Estudo comparativo randomizado do implante de Stent de aço inoxidável recoberto por carbono semelhante ao diamante versus não recoberto em pacientes com doença arterial coronariana

“…Stent surface coating with hemocompatible and biocompatible material may reduce thrombogenicity by reducing platelet adhesion and activation, and inflammatory response by reducing the release of cytotoxic metal ions [8][9][10][11][12][13][14] . Stent coating may be divided into two categories: biocompatible materials and drug-eluting coatings (ex.…”