Restorative potentiality of S-allylcysteine against diabetic nephropathy through attenuation of oxidative stress and inflammation in streptozotocin–nicotinamide-induced diabetic rats

Uddandrao, V. V. Sathibabu; Parim, Brahmanaidu; Ramavat, Ravindarnaik; Palaniyandi, Suresh S.; Vadivukkarasi, S.; Saravanan, G.

doi:10.1007/s00394-018-1795-x

Cited by 52 publications

(17 citation statements)

References 45 publications

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“…Oxidative stress is caused by either overproduction of ROS, due to stress, environmental factors, lifestyle changes, etc., or due to inadequate cellular antioxidant levels in various biological systems. The endogenous antioxidant enzyme defense system plays a significant role in scavenging the ROS in tissue injury and in maintaining cellular integrity by their reducing properties (Sathibabu Uddandrao et al., 2018, 2019). Superoxide dismutase, catalase, and GPx form the first‐line cellular defense system present in a biological system to scavenge free radicals in oxidative damage by decomposing hydrogen peroxide and superoxide radicals (Griendling & FitzGerald, 2003).…”

Section: Discussionmentioning

confidence: 99%

Phenolic fraction extracted from Kedrostis foetidissima leaves ameliorated isoproterenol‐induced cardiotoxicity in rats through restoration of cardiac antioxidant status

Pavithra¹,

Uddandrao²,

Chandrasekaran³

et al. 2020

J. Food Biochem.

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Cardiovascular disease (CVD) is the most common cause of global mortality and morbidity (Huiyao, Jiayin, & Chaoxiang, 2019; Saranya & Padma, 2018), and it has been estimated to affect up to 23.3 million individuals by 2030 (Hui et al., 2017). CVD refers to blood vessel and heart disorders, including coronary artery disease (CAD), elevated blood pressure, stroke, congenital heart defects, and congestive heart failure. Elevated generation of reactive oxygen species (ROS) leads to severe oxidative stress on the myocardium, which predisposes an individual to CVD, including congestive heart failure, ischemic heart disease, and atherosclerosis (Wattanapitayakul & Bauer, 2001). Myocardial infarction (MI) is caused by a critical imbalance between the oxygen supply and the demand for the myocardium, which

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Section: Discussionmentioning

confidence: 99%

Phenolic fraction extracted from Kedrostis foetidissima leaves ameliorated isoproterenol‐induced cardiotoxicity in rats through restoration of cardiac antioxidant status

Pavithra¹,

Uddandrao²,

Chandrasekaran³

et al. 2020

J. Food Biochem.

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“…There is a balance between the production of ROS and the endogenous cellular antioxidant system, including enzymatic and nonenzymatic, under physiological condition. However, more and more animal experiments and clinical investigations indicated that diabetes not only induced the overproduction of ROS but also might interfere the antioxidant defense system via regulating the activities of antioxidant enzyme [35]. Thus, to further prove the renoprotective effect of EVA, we explored the effect of EVA on the level of SOD, CAT, and GSH-Px, important antioxidases in the antioxidant defense system in renal damage, in vivo and in vitro .…”

Section: Discussionmentioning

confidence: 99%

Ethyl Vanillin Protects against Kidney Injury in Diabetic Nephropathy by Inhibiting Oxidative Stress and Apoptosis

Tong

Liu

Gong

et al. 2019

Oxidative Medicine and Cellular Longevity

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Diabetes-induced oxidative stress and apoptosis is regarded as a critical role in the pathogenesis of diabetic nephropathy (DN). Treating diabetes-induced kidney damage and renal dysfunction has been thought a promising therapeutic option to attenuate the development and progression of DN. In this study, we investigated the renoprotective effect of ethyl vanillin (EVA), an active analogue of vanillin isolated from vanilla beans, on streptozotocin- (STZ-) induced rat renal injury model and high glucose-induced NRK-52E cell model. The EVA treatment could strongly improve the deterioration of renal function and kidney cell apoptosis in vivo and in vitro. Moreover, treating with EVA significantly decreased the level of MDA and reactive oxygen species (ROS) and stabilized antioxidant enzyme system in response to oxidative stress by enhancing the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in vivo and in vitro. Furthermore, EVA also markedly suppressed cleaved caspase-3, Bax, and nuclear transcription factor erythroid 2-related factor (Nrf2) expression in STZ-induced rats. Therefore, these results of our investigation provided that EVA might protect against kidney injury in DN by inhibiting oxidative stress and cell apoptosis.

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“…Diabetes mellitus (DM) is characterized by persistent hyperglycemia with an inability to fully utilize glucose and maintain insulin homeostasis, which leads to long-term damage and dysfunction of the eyes, kidneys, and nervous and cardiovascular systems in particular (1). Approximately 366,000,000 individuals are expected to suffer from DM by the year 2030, and almost 592,000,000 individuals, or 1/10, are anticipated to have diabetes by 2035 (1,2). It is estimated that >40% of diabetic patients require regular, painful and expensive dialysis due to end-stage renal disease (ESRD), and the mortality rate remains high (3).…”

Section: Introductionmentioning

confidence: 99%

“…Diabetic nephropathy (DN) is an emerging clinical and public health challenge, which is also a life-threatening long-term microvascular complication of type 1 DM (T1DM) and type 2 DM (T2DM) (1,4,5). Patients with DN are generally hypertensive, which increases the risk of cardiovascular disease and mortality (6); hypertension is interconnected with the initiation and progression of DN.…”

Section: Introductionmentioning

confidence: 99%

Identification of potential therapeutic target genes in mouse mesangial cells associated with diabetic nephropathy using bioinformatics analysis

Mou¹,

Zhou²,

Liu³

et al. 2019

Exp Ther Med

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The aim of the present study was to identify genes under the effect of transforming growth factor-β (TGF-β1), high glucose (HG) and glucosamine (GlcN) in MES-13 mesangial cells and elucidate the molecular mechanisms of diabetic nephropathy (DN). The gene expression datasets GSE2557 and GSE2558 were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were independently screened using the GEO2R online tool. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed using the Database for Annotation, Visualization, and Integrated Discovery. The protein-protein interaction (PPI) network was constructed using the Search Tool for the Retrieval of Interacting Genes and Cytoscape software. The hub genes were identified by the NetworkAnalyzer plugin. Overlapping genes were subjected to molecular docking analysis using SystemsDock. A total of 202 upregulated and 158 downregulated DEGs from the HG-treated groups, 138 upregulated and 103 downregulated DEGs from the GlcN-treated groups, and 81 upregulated and 44 downregulated DEGs from the TGF-β1-treated groups were identified. The majority of the DEGs were independently enriched in ‘nucleosome assembly’, ‘chromatin silencing’ and ‘xenobiotic glucuronidation’. In addition, KEGG pathways were significantly enriched in ‘systemic lupus erythematosus’, ‘protein processing in endoplasmic reticulum’ and ‘aldarate metabolism pathway’, and ‘TNF signaling pathway’ intersected in the TGF-β1-treated and HG-treated groups. In total, eight hub genes, Jun, prostaglandin-endoperoxide synthase 2 (Ptgs2), fibronectin 1 (Fn1), cyclin-dependent kinase (Cdk)2, Fos, heat shock protein family A (Hsp70) member 5 (Hspa5), Hsp90b1 and homo sapiens hypoxia upregulated 1 (Hyou1), and three overlapping genes, Ras homolog gene family, member B (RHOB), complement factor H (CFH) and Krüppel-like factor 15 (KLF15), were selected. Valsartan with RHOB, and fosinopril with CFH and KLF15 had preferential binding activity. In conclusion, Jun, Ptgs2, Fn1, Cdk2, Fos, Hspa5, Hsp90b1, Hyou1, RHOB, CFH and KLF15 may be potential therapeutic targets for mesangial cells associated with DN, which may provide insight into DN treatment strategies.

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Restorative potentiality of S-allylcysteine against diabetic nephropathy through attenuation of oxidative stress and inflammation in streptozotocin–nicotinamide-induced diabetic rats

Cited by 52 publications

References 45 publications

Phenolic fraction extracted from Kedrostis foetidissima leaves ameliorated isoproterenol‐induced cardiotoxicity in rats through restoration of cardiac antioxidant status

Phenolic fraction extracted from Kedrostis foetidissima leaves ameliorated isoproterenol‐induced cardiotoxicity in rats through restoration of cardiac antioxidant status

Ethyl Vanillin Protects against Kidney Injury in Diabetic Nephropathy by Inhibiting Oxidative Stress and Apoptosis

Identification of potential therapeutic target genes in mouse mesangial cells associated with diabetic nephropathy using bioinformatics analysis

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