Phenolic fraction extracted from Kedrostis foetidissima leaves ameliorated isoproterenol‐induced cardiotoxicity in rats through restoration of cardiac antioxidant status

Abstract

Cardiovascular disease (CVD) is the most common cause of global mortality and morbidity (Huiyao, Jiayin, & Chaoxiang, 2019; Saranya & Padma, 2018), and it has been estimated to affect up to 23.3 million individuals by 2030 (Hui et al., 2017). CVD refers to blood vessel and heart disorders, including coronary artery disease (CAD), elevated blood pressure, stroke, congenital heart defects, and congestive heart failure. Elevated generation of reactive oxygen species (ROS) leads to severe oxidative stress on the myocardium, which predisposes an individual to CVD, including congestive heart failure, ischemic heart disease, and atherosclerosis (Wattanapitayakul & Bauer, 2001). Myocardial infarction (MI) is caused by a critical imbalance between the oxygen supply and the demand for the myocardium, which

Cardioprotective potential of the antioxidant-rich bioactive fraction of Garcinia pedunculata Roxb. ex Buch.-Ham. against isoproterenol-induced myocardial infarction in Wistar rats

“…In cardioprotective studies with sericin, bergapten, phenolic compounds rich extracts of Zygophyllum album, Kedrostis foetidissima, it was seen that their successful treatment reduced the lipid peroxidation and revamped the endogenous antioxidant system, thereby protecting the cardiac muscles against the oxidative damage. This study's results agree with these reports from Pavithra et al, 2020;Feriani et al, 2020;Yang et al, 2022;and Ahsan et al, 2022. The role of GC pretreatment in successfully reducing TBARS in cardiac tissues and increasing the levels of SOD, GSH, and catalase proved its potent antioxidant potential which is responsible for its successful cardioprotective action.…”

Phytoformulation with hydroxycitric acid and capsaicin protects against high-fat-diet-induced obesity cardiomyopathy by reducing cardiac lipid deposition and ameliorating inflammation and apoptosis in the heart

“… 27 To combat these clinical changes, the use of medicinal herbs and the plant based active compounds continues to be a complementary treatment option, including CVD, as demonstrated by various researchers. 28 , 29 , 30 Therefore, the present study sought to evaluate the therapeutic efficacy of phytoformulation with HCA and capsaicin against HFD-induced OCM using a rat model.…”