Resting Metabolic Rate in Monozygotic and Dizygotic Twins

Fontaine, E.; Savard, Rémi; Tremblay, Angelo; Després, Jean‐Pierre; Poehlman, Éric T.; Bouchard, Claude

doi:10.1017/s0001566000004906

Cited by 66 publications

(29 citation statements)

References 15 publications

(20 reference statements)

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Section: Rmr and Free Living Eementioning

confidence: 99%

“…In publications from Fontaine et al 26 and Bouchard et al, 27 genetic contributions to RMR are estimated. RMR was obtained by indirect calorimetry for 39 twin pairs in the ®rst study 26 and 58 twin pairs and 31 parent-child pairs in the second study. 27 Heritability estimates based on twice the difference between MZ and DZ correlations, and twice the parent-child correlations, suggest that about 40% of the variance in RMR, after adjustment for age, gender, body mass and body composition, may be heritable.…”

Section: Rmr and Free Living Eementioning

confidence: 99%

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Genetic determinants of sports participation and daily physical activity

1999

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OBJECTIVE: The purpose is to review the existing literature on genetic determinants of sports participation, daily physical activity (PA) resting metabolic rate (RMR) and activity as a temperamental trait. DESIGN: A synthesis will be given of the published material on this topic with special focus on twin and family data, and association and linkage studies. MEASUREMENTS: Self reported sports participation, daily PA, RMR and activity as a temperamental trait. ANALYSIS: Transmission and heritability coef®cients calculated from twin and family data will be reported. RESULTS: The reported heritability coef®cients for sports participation vary between 0.35 ± 0.83, and those for daily PA between 0.29 ± 0.62. If one of the parents or co-twins is active in sports, it is more likely that the child or co-twin is also active in sports (odds ratios (ORs) vary from 1.2 ± 5.8). Twin and parent-child correlations for RMR also indicate a moderate genetic effect. At present, only a linkage between RMR and uncoupling protein 2 markers has been demonstrated. CONCLUSION: The genetic determination of sports participation, daily PA and RMR, varies from low to moderately high, and only between the uncoupling protein 2 genetic marker and RMR has a linkage has been demonstrated.

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Section: Rmr and Free Living Eementioning

confidence: 99%

Section: Rmr and Free Living Eementioning

confidence: 99%

Genetic determinants of sports participation and daily physical activity

1999

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“…1 For example, it has been shown that the intra-class correlation coefficient for REE in monozygotic twins was much higher than that in dizygotic twins. 4 A large number of genes have been implicated in obesityrelated phenotypes. 5 Perhaps the best documented obesity gene polymorphism is in the FTO gene.…”

Section: Introductionmentioning

confidence: 99%

Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB Study

et al. 2009

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Background: Part of the heterogeneity of the obesity phenotype may originate from genetic differences between obese individuals that may influence energy expenditure (EE). Objective: To examine if common single-nucleotide polymorphisms (SNPs) in genes related to obesity-associated phenotypes are associated with postabsorptive resting energy expenditure (REE) and postprandial REE in obese individuals. Design and methods: Postabsorptive REE and 3-h postprandial REE (liquid test meal containing 95% fat, energy content 50% of estimated REE) were measured in 743 obese individuals from eight clinical centres in seven European countries. The analysis assessed the association of genotypes of 44 SNPs in 28 obesity-related candidate genes with postabsorptive REE and postprandial REE taking into consideration the influence of body composition, habitual physical activity, insulin sensitivity, circulating thermogenic hormones and metabolites. Results: After adjustment for fat-free mass (FFM), age, sex and research centre, SNPs in CART, GAD2, PCSK1, PPARG3, HSD11B1 and LIPC were significantly associated with postabsorptive REE. SNPs in GAD2, HSD11B1 and LIPC remained significantly associated with postabsorptive REE after further adjustment for fat mass (FM). SNPs in CART, PPARG2 and IGF2 were significantly associated with postprandial REE after similar adjustments. These associations with postprandial REE remained significant after further adjustment for FM. FTO, UCP2 and UCP3 variants were not associated with postabsorptive or postprandial REE. Conclusions: Several gene polymorphisms associated with obesity-related phenotypes but not FTO and UCP variants may be responsible for some of the inter-individual variability in postabsorptive REE and fat-induced thermogenesis unaccounted for by FFM, FM, age and sex. The association between FTO and obesity that has been reported earlier may not be mediated directly through modulation of EE in obese individuals.

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“…3 A familial aggregation was demonstrated for metabolic rate 4 and respiratory quotient (RQ), an indicator of CHOOX to FATOX. 5 Twin studies 6,7 suggested a genetic influence on resting metabolic rate. A linkage study in Pima Indians detected quantitative trait loci (QTLs) on chromosome 1p31 and 20q11.2 influencing 24-h respiratory quotient (24RQ).…”

Section: Introductionmentioning

confidence: 99%

Genome-wide scan revealed genetic loci for energy metabolism in Hispanic children and adolescents

et al. 2008

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Objective: Genome-wide scans were conducted in search for genetic locations linked to energy expenditure and substrate oxidation in children. Design: Pedigreed data of 1030 Hispanic children and adolescents were from the Viva La Familia Study which was designed to investigate genetic and environmental risk factors for the development of obesity in Hispanic families. A respiratory calorimeter was used to measure 24-h total energy expenditure (TEE), basal metabolic rate (BMR), sleep metabolic rate (SMR), 24-h respiratory quotient (24RQ), basal metabolic respiratory quotient (BMRQ) and sleep respiratory quotient (SRQ). Protein, fat and carbohydrate oxidation (PROOX, FATOX and CHOOX, respectively) were also estimated. All participants were genotyped for 384 single tandem repeat markers spaced an average of 10 cM apart. Computer program SOLAR was used to perform the genetic linkage analyses. Results: Significant linkage for TEE was detected on chromosome 1 near marker D1S2841, with a logarithm of the odds (LOD) score of 4.0. SMR, BMRQ and PROOX were associated with loci on chromosome 18, 17 and 9, respectively, with LOD scores of 4.88, 3.17 and 4.55, respectively. A genome-wide scan of SMR per kg fat-free mass (SpFFM) peaked in the same region as SMR on chromosome 18 (LOD, 5.24). Suggestive linkage was observed for CHOOX and FATOX. Several candidate genes were found in the above chromosomal regions including leptin receptor (LEPR). Conclusion: Regions on chromosomes 1, 9, 17 and 18 harbor genes affecting variation in energy expenditure and substrate oxidation in Hispanic children and adolescents.

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Resting Metabolic Rate in Monozygotic and Dizygotic Twins

Cited by 66 publications

References 15 publications

Genetic determinants of sports participation and daily physical activity

Genetic determinants of sports participation and daily physical activity

Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB Study

Genome-wide scan revealed genetic loci for energy metabolism in Hispanic children and adolescents

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