Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB Study

Goossens, Gijs H.; Petersen, Liselotte; Blaak, Ellen E.; Hul, Gabby B.; Arner, Peter; Astrup, Arne; Froguel, Philippe; Patel, Kishor; Pedersen, Oluf; Polàk, Jan; Jm, Oppert; Martínéz, J. Alfredo; Sørensen, Thorkild I. A.; Saris, Wim H. M.

doi:10.1038/ijo.2009.59

Cited by 33 publications

(21 citation statements)

References 40 publications

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“…In addition, Vimaleswaran et al [43] found a similar effect for the rs1121980 FTO variant. However, other studies on the effect of FTO rs9939609 polymorphism on energy expenditure showed that the link between the gene variants and fatness is not explained by physical activity level either in children [44] or in adults [45][46][47].…”

Section: Observational Studiesmentioning

confidence: 89%

Effects of theFTOGene on Lifestyle Intervention Studies in Children

Rendo

Moleres

Marti³

2009

Obes Facts

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The effects of FTO on body weight, body composition, and the risk of developing overweight and obesity in children, adolescents, and adults are analyzed in this review. Most trails have been conducted on the rs9939609 SNP of the FTO gene. The minor A-allele frequency ranged from 0.38 to 0.49 in different European populations. Briefly, it has been reported that overweight-obesity risk per A-allele ranged from 1.76 to 1.35, whereas z-score for BMI has a wider variation from 0.05 to 0.5 kg/m² in European children and adolescents. As for other adiposity indexes, a waist circumference increase from 0.60 to 0.95 cm per A-allele was found together with an increase in fat mass from 0.68 to 1.78 kg in European children and adoles-cents. In regard to food intake, AA carrier subjects were reported to have reduced satiety responsiveness scores and a higher total energy and fat intake. However, it is not clear whether energy expenditure did modify the role of the rs9939609 FTO gene variant in adiposity. Furthermore, few reports examined the influence of FTO gene variants using intervention studies. Overall, it seems that the A-allele (rs9939609 FTO) is associated with higher body weight gain. However, further studies into FTO gene variants in children and adults are needed.

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Section: Observational Studiesmentioning

confidence: 89%

Effects of theFTOGene on Lifestyle Intervention Studies in Children

Rendo

Moleres

Marti³

2009

Obes Facts

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“…The enhancement in obesity risk linked to a high CHO intake may be partly explained by the fact that CHO are not able to activate the PPARG protein and could worsen the action of the Ala12 substitution on the receptor activity. The impact of this rs9939609 SNP of FTO gene on human body weight is mainly through energy intake; however, some results are contradictory (Berentzen et al 2008;Do et al 2008;Speakman et al 2008, Goossens et al 2009Haupt et al 2009). In our elderly population, no effect of FTO on obesity was found.…”

Section: Discussionmentioning

confidence: 99%

Lifestyle factors modify obesity risk linked to PPARG2 and FTO variants in an elderly population: a cross-sectional analysis in the SUN Project

et al. 2012

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Genetic factors may interact with lifestyle factors to modify obesity risk. FTO and PPARG2 are relevant obesogenes. Our aim was to explore the effect of Pro12Ala (rs1801282) of PPARG2 and rs9939609 of FTO on obesity risk and to examine their interaction with lifestyle factors in an elderly population. Subjects (n = 978; aged 69 ± 6) were recruited from the SUN (Seguimiento Universidad de Navarra) Project. DNA was obtained from saliva, and lifestyle and dietary data were collected by validated self-reported questionnaires. Genotyping was assessed by RT-PCR plus allele discrimination. Subjects carrying the Ala allele of PPARG2 gene had a significantly increased obesity risk compared to non-carrier (Pro12Pro) subjects (OR, 1.66; 95 % CI, 1.01-2.74; p = 0.045). Greater obesity risk was also found in inactive or high carbohydrate intake subjects with the Ala12 allele of PPARG2 gene. Interestingly, subjects carrying the Ala allele of the PPARG2 gene and with a high CHO ([246 g/ day) intake had an increased obesity risk compared to Pro12Pro subjects (OR, 2.67; 95 % CI, 1.3-5.46; p = 0.007; p for [CHO 9 PPARG2] interaction = 0.046). Moreover, in subjects with a high CHO intake, the co-presence of the Ala allele of PPARG2 gene and one minor A allele (rs9939609) of FTO gene did increase obesity risk (OR, 3.26; 95 % CI,; p = 0.021) when compared to non-carrier (Pro12Pro/TT) subjects. In conclusion, it appears that lifestyle factors may act as effect modifiers for obesity risk linked to Ala12 allele of the PPARG2 gene and the minor A allele of FTO gene in an elderly population.

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“…10,12,13 However, few intervention studies have explored the interaction between lifestyle changes and FTO gene variant on adiposity indices or metabolic outcomes. [5][6][7][8][9]14 Two studies performed on diabetic subjects did not find any association. 8,9 To explore the possible contribution of diet as an effect modifier on the role of rs9939609 FTO gene variant on body weight changes, long-term nutritional intervention trials are necessary.…”

Section: Introductionmentioning

confidence: 87%

A 3-year intervention with a Mediterranean diet modified the association between the rs9939609 gene variant in FTO and body weight changes

et al. 2009

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Introduction: The aim of this study was to analyze the effects of the rs9939609 (T/A) gene variant in fat mass and obesityassociated gene (FTO) on body weight changes after 3 years and its modification by a randomized nutritional intervention with a Mediterranean-style diet in a population of subjects at high cardiovascular risk. Design: A substudy of PREDIMED, which is a randomized trial aimed at assessing the effect of the Mediterranean diet (MD) for primary cardiovascular disease prevention. There were three nutritional intervention groups: two of them with a Mediterraneanstyle diet and the third was a control group advised to follow a conventional low-fat diet. Subjects: A total of 776 high cardiovascular risk subjects aged 55-80 years. Measurements: Anthropometric measurements were recorded at baseline and at 3 years. The participants were genotyped by RT-PCR, followed by allelic discrimination. Results: Homozygous subjects had the highest baseline body weight. The dominant model showed that subjects carrying the A allele had the lowest body weight gain (B ¼ À0.685; P ¼ 0.022) after 3 years of nutritional intervention compared with nonmutated subjects (TT genotype) regardless of the nutritional intervention. Moreover, this effect was statistically significant in carriers of the A allele only among those allocated to the MD groups (B ¼ À0.830; P ¼ 0.018), but it was not significant among those allocated to the control group (P for interaction ¼ 0.649). Conclusion: This study confirmed the association between body weight and the FTO rs9939609 polymorphism. Interestingly, our results showed that, although at baseline the A allele was associated with higher body weight, after 3 years of nutritional intervention with a Mediterranean-style-diet, A-allele carriers had lower body weight gain than wild type subjects. No interaction between nutritional intervention and the polymorphism was found.

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Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB Study

Cited by 33 publications

References 40 publications

Effects of theFTOGene on Lifestyle Intervention Studies in Children

Effects of theFTOGene on Lifestyle Intervention Studies in Children

Lifestyle factors modify obesity risk linked to PPARG2 and FTO variants in an elderly population: a cross-sectional analysis in the SUN Project

A 3-year intervention with a Mediterranean diet modified the association between the rs9939609 gene variant in FTO and body weight changes

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