Responses of plasma vasoactive intestinal polypeptide to methacholine and exercise loading in children and adolescents with bronchial asthma

Abstract

Responses of plasma vasoactive intestinal polypeptide (VIP) to methacholine inhalation and to exercise loading were studied in asthmatic patients to clarify a significant role of the peptide. The mean of basal VIP in asthmatics was not significantly different from the normals. The levels were increased after FEV (1.0) (forced expiratory volume in a second) decreased to 80% of the baseline following methacholine inhalation and were returned to values similar to the baseline when FEV (1.0) recovered to 100%. Thirty minutes after the exercise, mean VIP was significantly lower in patients with the lowest FEV (1.0). These results suggest that VIPergic system contributes, at least partly, to relax constricted bronchioles in some patients with bronchial asthma.

Catalytic Hydrolysis of VIP in Pregnant Women with Asthma

“…Plasma VIP levels are elevated by exercise challenge in asthmatic children, potentially reflecting the protective role of the peptide (27). Inhalation of a VIP receptor agonist is reported to induce bronchodilation in asthmatic subjects in a small but controlled clinical trial (28).…”

Vasoaktives Intestinales Polypeptid (VIP) im Atemtrakt: Physiologie und Pathophysiologie

“…Auch wurden VIP-neutralisierende Antikörper im Patientenserum gefunden [115]. Eine klinische Studie bezüglich der Zusammenhänge von VIP-Plasmaspiegeln und körperlicher Belastung bei Kindern mit Asthma zeigte, dass belastungsinduziertes Asthma mit erhöhten VIP-Plasmaspiegeln einhergeht [116]. Im Gegensatz dazu waren bei erhöhten CGRP-, Substanz P-und NPY-Spiegeln die Plasmaspiegel von VIP bei Patienten mit schweren Asthmaattacken verringert [117].…”