2006
DOI: 10.1080/02770900600710730
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Catalytic Hydrolysis of VIP in Pregnant Women with Asthma

Abstract: An increase in the VIP hydrolyzing activity of IgG is independently associated with asthma and pregnancy. The autoantibodies hold the potential of affecting the pathophysiology of the airways in pregnant asthmatics.

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Cited by 10 publications
(5 citation statements)
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References 29 publications
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“…In the above study, autoantibodies against alphaenolase protein induced an apoptotic cell death of retinal cells without an addition of complement. Autoantibodies to vasoactive intestinal peptide purified from asthmatic patients showed a catalytic enzyme-like activity [32]. We suppose that IgG autoantibodies against airway epithelial cell autoantigens (cytokeratin 18 and alpha-enolase) from patients with nonallergic asthma could directly induce cytotoxic damage to airway epithelial cells.…”
Section: Discussionmentioning
confidence: 99%
“…In the above study, autoantibodies against alphaenolase protein induced an apoptotic cell death of retinal cells without an addition of complement. Autoantibodies to vasoactive intestinal peptide purified from asthmatic patients showed a catalytic enzyme-like activity [32]. We suppose that IgG autoantibodies against airway epithelial cell autoantigens (cytokeratin 18 and alpha-enolase) from patients with nonallergic asthma could directly induce cytotoxic damage to airway epithelial cells.…”
Section: Discussionmentioning
confidence: 99%
“…Our hypothesis is in agreement with previous reports in murine models which demonstrated modulatory effects of thyroid hormone on VIP mRNA levels in different adult brain areas 23 and an upregulation of VIP content in the anterior pituitary gland under hypothyroid conditions 24 26 . Besides, our results link GD to other inflammatory/autoimmune diseases where VIP serum levels are decreased, such as juvenile idiopathic arthritis (JIA) 27 , early arthritis 15 , SpA 17 , osteoarthritis 28 and asthma 29 . Moreover, the fact that only the hyperthyroid subgroup with recent onset GD showed reduced VIP levels, suggests an association between low VIP levels and disease activity, as it has also been previously demonstrated in patients with early arthritis 15 , 16 , SpA 17 , Chagas cardiomyopathy 30 and JIA 27 .…”
Section: Discussionmentioning
confidence: 64%
“…The VIP serum levels also correlated with the response to bronchodilator therapy, showing a better response in patients with higher VIP serum levels [28]. Catalytic auto-antibodies against VIP may play a role in serum from asthmatics with acute exacerbations [29,30]. Taken together, VIP seems to be effective in dilating pre-contracted bronchi, but shows no significant effect in bronchi with normal tonus.…”
Section: Asthmamentioning
confidence: 72%