Vasoaktives Intestinales Polypeptid (VIP) im Atemtrakt: Physiologie und Pathophysiologie

Groneberg, David A.; Rabe, Klaus F.; Wagner, U.; Fischer, Axel

doi:10.1055/s-2004-818352

Cited by 8 publications

(4 citation statements)

References 71 publications

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“…The possibility to functionally assess the secretory activity under defined experimental conditions offers the chance to study the effects of potential new compounds on airway secretion in COPD. Also, the effects of mediators of inflammation including reactive oxygen species [ 61 ] or neuromediators [ 62 , 63 ] and drug transport mechanisms [ 64 , 65 ] can be assessed in a setting of phlegm production and bronchitis.…”

Section: Discussionmentioning

confidence: 99%

Analysis of airway secretions in a model of sulfur dioxide induced chronic obstructive pulmonary disease (COPD)

Wagner

Staats

Fehmann

et al. 2006

J Occup Med Toxicol

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Hypersecretion and chronic phlegm are major symptoms of chronic obstructive pulmonary disease (COPD) but animal models of COPD with a defined functional hypersecretion have not been established so far. To identify an animal model of combined morphological signs of airway inflammation and functional hypersecretion, rats were continuously exposed to different levels of sulfur dioxide (SO2, 5 ppm, 10 ppm, 20 ppm, 40 ppm, 80 ppm) for 3 (short-term) or 20–25 (long-term) days. Histology revealed a dose-dependent increase in edema formation and inflammatory cell infiltration in short-term-exposed animals. The submucosal edema was replaced by fibrosis after long-term-exposure. The basal secretory activity was only significantly increased in the 20 ppm group. Also, stimulated secretion was significantly increased only after exposure to 20 ppm. BrdU-assays and AgNOR-analysis demonstrated cellular metaplasia and glandular hypertrophy rather than hyperplasia as the underlying morphological correlate of the hypersecretion.In summary, SO2-exposure can lead to characteristic airway remodeling and changes in mucus secretion in rats. As only long-term exposure to 20 ppm leads to a combination of hypersecretion and airway inflammation, only this mode of exposure should be used to mimic human COPD. Concentrations less or higher than 20 ppm or short term exposure do not induce the respiratory symptom of hypersecretion. The present model may be used to characterize the effects of new compounds on mucus secretion in the background of experimental COPD.

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Section: Discussionmentioning

confidence: 99%

Analysis of airway secretions in a model of sulfur dioxide induced chronic obstructive pulmonary disease (COPD)

Wagner

Staats

Fehmann

et al. 2006

J Occup Med Toxicol

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“…Vasoactive intestinal peptide (VIP), a gastrointestinal hormone in the secretin–VIP family, was discovered by Said and Mutt in 1970 1 and has extensive physiological functions involving various activities of the digestive, respiratory, circulating, urogenital, and nervous systems 2,3 . The physiological functions of VIP in the gastrointestinal tract are associated with secretory and digestive motor functions 4 .…”

Section: Introductionmentioning

confidence: 99%

“…The physiological functions of VIP in the gastrointestinal tract are associated with secretory and digestive motor functions 4 . VIP exerts its actions by binding to specific membrane receptors (VIPR 1 , VIPR 2 ) 2–4 . VIPR are G protein‐coupled receptors, which are distributed in most human tissues 5–7 .…”

Section: Introductionmentioning

confidence: 99%

Effect of vasoactive intestinal peptide on gastric adenocarcinoma

Qian

Song

et al. 2007

J of Gastro and Hepatol

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The expression of VIP mRNA upregulates, but the expressions of VIPR mRNA downregulates in gastric adenocarcinoma tissues. The gastric adenocarcinoma tissues contain endocrine cells to secrete VIP, which show malignant specialities. The VIP autocrine regulation exists in SGC7901 cells, and potentially inhibits the proliferation of the cells by downregulating the expressions of c-myc and ODC mRNA. It suggests that VIP may play an important role in the regulation of the growth of gastric cancer cells.

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“…Die Hauptwirkungen in den Atemwegen sind vaso-und bronchodilatatorische Effekte bzw. eine Steigerung der glandulären Sekretion[11,20,32,33]. Unter physiologischen Bedingungen werden die parasympathischen Reaktionen als nasale Schutz-und Reinigungsmechanismen (z.…”

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Idiopathische Rhinitis

Damm¹

2006

Laryngorhinootologie

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Idiopathic Rhinitis (IR) is a term for a group of nasal diseases of unknown aetiology. Formerly, these diseases were called vasomotor rhinitis, but because there is no indication of a disorder in the vasomotor system, this term has been abandoned. Other terms, like non-infectious non-allergic rhinitis and non-allergic non-infectious perennial rhinitis are purely descriptive. Potential pathomechanisms in IR could be 1) neural dysfunction/dysregulation; 2) immunological inflammatory responses; and 3) changes of the permeability of the mucosa, leading to increase entrance of potential harmful substances. Idiopathic Rhinitis is a diagnosis by exclusion, meaning that a number of more or less defined nasal conditions as a cause of rhinitis have been excluded - not only allergic rhinitis. Although a considerable progress was made in the standardization of provocation tests or biomarkers in nasal secretions, there are today no specific test available to confirm the diagnosis rhinitis in many non allergic conditions. An evidence-based review of treatment outcomes shows topical sprays of steroids, antihistamines to be of benefit in idiopathic rhinitis. Furthermore, nasal saline solution is effective in many patients with IR. Multiple surgical procedures have been suggested for IR, but should be reserved for patients who fail medical therapy.

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Vasoaktives Intestinales Polypeptid (VIP) im Atemtrakt: Physiologie und Pathophysiologie

Cited by 8 publications

References 71 publications

Analysis of airway secretions in a model of sulfur dioxide induced chronic obstructive pulmonary disease (COPD)

Analysis of airway secretions in a model of sulfur dioxide induced chronic obstructive pulmonary disease (COPD)

Effect of vasoactive intestinal peptide on gastric adenocarcinoma

Idiopathische Rhinitis

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