Responses of Normal Cells to Ionizing Radiation

Effects of genistein following fractionated lung irradiation in mice

“…It has been shown that radiation causes premature terminal differentiation of fibroblasts causing increased synthesis and extracellular deposition of collagen [175]. Since such cells become post mitotic they may harbour DNA damage undetected by the MN assay while still contributing to the progression of tissue remodeling and altering recruitment of inflammatory cells.…”

Therapeutic effect of compound of White Peony Root Oral Liquids on radiation-induced esophageal toxicity via the expression of EGF and TGF-β1

“…The fibroblast cell system plays a predominant role on the fibrotic process due to its secretary function, which produces the components of ECM and ensures its renewal in a balance between synthesis and degradation. Similar to other fibrotic responses, RIF is a multi-cell process driven by intercellular communications via cytokines and growth factors (22,23,25) (Fig. 6).…”

“…Late reactions following radiation exposure include fibrosis, organ dysfunction and tissue necrosis (23). Of these reactions, fibrosis is a fundamental pathological process (8,10,23,24).…”

“…Of these reactions, fibrosis is a fundamental pathological process (8,10,23,24). The fibroblast cell system plays a predominant role on the fibrotic process due to its secretary function, which produces the components of ECM and ensures its renewal in a balance between synthesis and degradation.…”

Plant Extracts and Plant-Derived Compounds: Promising Players in Countermeasure Strategy Against Radiological Exposure: A Review

“…Radiation-induced inflammation, an important side effect that contributes to normal tissue injury, has been reported in many species (Linard et al, 2004;Fliedner et al, 2005;Kong et al, 2005;Fleckenstein et al, 2007;Haston et al, 2007;Rodemann and Blaese, 2007;Hill et al, 2011;Multhoff and Radons, 2012;Rastogi et al, 2012;Cho et al, 2013;Fu et al, 2013;Jiang et al, 2013;McCurdy et al, 2013;Moore et al, 2013;Mukherjee et al, 2014). The initial phase of radiationinduced injury is marked by the increase in the synthesis of pro-inflammatory cytokines such as transforming growth factor-beta1 (TGF-β1), tumor necrosis factor-alpha (TNF-α) and several other members of interleukin (IL) family (Linard et al, 2004;Fliedner et al, 2005;Kong et al, 2005;Mehta, 2005;Fleckenstein et al, 2007;Haston et al, 2007;Rodemann and Blaese 2007;Jindal et al, 2009;Hei et al, 2011;Janko et al, 2012;Monceau et al, 2013). The hallmark late effect of radiation exposure in several experimental animals is fibrosis, which is often permanent (Han et al, 2006;Lee et al, 2009;Flechsig et al, 2010;Qiu et al, 2011;Gorshkova et al, 2012;Cho et al, 2013;Ding et al, 2013;Horton et al, 2013).…”