Therapeutic effect of compound of White Peony Root Oral Liquids on radiation-induced esophageal toxicity via the expression of EGF and TGF-β1

Abstract

Abstract. The predominant pathological processes of radiation-induced esophageal toxicity include inflammatory reactions in the early stage and the fibrotic process in the late stage. An increased expression of the epidermal growth factor (EGF) and transforming growth factor β1 (TGF-β1) is capable of reducing inflammatory reactions and TGF-β1 is considered responsible for the initiation, development and persistence of fibrosis. In the present study, we investigated in vivo the therapeutic effect of the compound of white peony root oral liquids (cWPROL) on reducing the toxicity via modulating the expression levels of EGF and TGF-β1. Adult male Wistar rats were treated and tissue sections were obtained. The tissue sections were stained using histological, Masson and immunohistochemical staining. The results revealed that cWPROL had a higher rate of repairing damaged structures compared with the control group. In addition, immunohistochemistry showed that although cWPROL and the mixture of lidocaine, dexamethasone and gentamycin (mLDG) induced levels of EGF and TGF-β1 expression, there were differences between the two types of intervention. These results are significant for understanding that the mechanism of therapeutic effect of cWPROL varied to some extent from that of mLDG.

Therapeutic effect of dental pulp stem cell transplantation on a rat model of radioactivity-induced esophageal injury

“…Meanwhile, SCs were transplanted via a vein in this study; this method has the advantage of being simple, widely applicable, safe, feasible, and highly effective. Directing the site-specific differentiation of DPSCs demands an accurate animal model, and the previous methods used to create animal models mainly relied on external exposure 34 , 35 and the use of a higher radiation dose rate to administer a large amount of radiation to the radiation field within a short period. The irradiation was large for these rats, and the mortality was high.…”

Utilization Pattern of Traditional Chinese Medicine among Fracture Patients: A Taiwan Hospital‐Based Cross‐Sectional Study

“…Shao-yao-gan-cao-tang was used for reducing limb or abdomen pain. The possible pharmacological mechanism is anti-inflammation [ 17 ]. According to the results, treatment in the middle period met the TCM goal of “joining the bone, soothing the sinews, and harmonizing construction of new sinews and bone”.…”

The modified Yi qi decoction protects cardiac ischemia-reperfusion induced injury in rats

“…Fructus Amomi is used to treat stomach disorders, pulmonary diseases and liver complaints [ 48 , 49 ], which also has antioxidant activity [ 50 ]. White Peony Root has been reported to promote the recovery of bone marrow hemopoietic function in a myelosuppressed mouse model [ 51 ], and its therapeutic effect on radiation-induced esophageal toxicity is also has been observed [ 52 , 53 ]. Based on above-mentioned literatures, composition of MYQ includes the herbs for improving cardiovascular and digestive function, and regulating immune system, which is accordance with the core concept of Wu Meng Therapy: treatment of cardiovascular diseases combined with circulatory and digestive systems.…”