Response to Comment on: Marchand and Polychronakos (2007) Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene with Diabetes: <i>Diabetes</i> 56:709–713

Marchand, Luc; Polychronakos, Constantin

doi:10.2337/db07-0836

Diabetes

2007

DOI: 10.2337/db07-0836

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Response to Comment on: Marchand and Polychronakos (2007) Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene with Diabetes: Diabetes 56:709–713

Luc Marchand¹,

Constantin Polychronakos²

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Cited by 2 publications

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“…Reserpine, yohimbine and ajmalicine are three major indole alkaloids in the extract of Rauvolfia rootstocks, branches and leaves, which have similar molecular structures as shown in Figs Reserpine can play an antihypertensive effect by exhuasting the adrenaline around sympathetic nerve endings and at the same time play a sedation effect by acting on the parts of hypothalamus 15 . Yohimbine can be used for the treatment of male sexual dysfunction, and has antiatherosclerotic and antirheumatic properties 16 . Ajmalicine has potent antiarrhythmic effects as well as antihypertensive effects.…”

mentioning

confidence: 99%

Simultaneous Determination of Reserpine, Yohimbine and Ajmalicine in the Extract of Rauvolfia Rootstocks, Branches and Leaves by HPLC

Du¹,

Feng²,

Wang³

et al. 2014

Asian J. Chem.

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mentioning

confidence: 99%

Simultaneous Determination of Reserpine, Yohimbine and Ajmalicine in the Extract of Rauvolfia Rootstocks, Branches and Leaves by HPLC

Du¹,

Feng²,

Wang³

et al. 2014

Asian J. Chem.

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Weight loss and metabolic benefits with diets of varying fat and carbohydrate content: separating the wheat from the chaff

Brehm

D’Alessio

2008

Nat Rev Endocrinol

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With the rising prevalence of both obesity and diabetes, the contributing role of diet to the prevention and treatment of these conditions has become a major focus of research, clinical practice, and public policy. There has been intense debate over which dietary regimens might be most effective for weight loss, with interest centered on the potential for specific dietary macronutrients to affect body composition, metabolism, and overall health. This Review addresses two regimens with distinct macronutrient prescriptions that have been widely touted as being beneficial for weight loss and/or metabolic profile: diets low in carbohydrate and diets high in monounsaturated fat. Although data from recent randomized, controlled trials suggest these popular diets may be useful for weight control, cardiovascular health, and glycemic control, longer studies of the efficacy and safety of varying macronutrient content are needed to strengthen the evidence base for nutritional recommendations. Until more support for specific macronutrient combinations is available, practitioners can recommend an array of diets with moderate amounts of macronutrients, tailored to individual needs and preferences.

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Response to Comment on: Marchand and Polychronakos (2007) Evaluation of Polymorphic Splicing in the Mechanism of the Association of the Insulin Gene with Diabetes: Diabetes 56:709–713

Cited by 2 publications

References 6 publications

Simultaneous Determination of Reserpine, Yohimbine and Ajmalicine in the Extract of Rauvolfia Rootstocks, Branches and Leaves by HPLC

Simultaneous Determination of Reserpine, Yohimbine and Ajmalicine in the Extract of Rauvolfia Rootstocks, Branches and Leaves by HPLC

Weight loss and metabolic benefits with diets of varying fat and carbohydrate content: separating the wheat from the chaff

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