Response surface method was used to optimize the ultrasonic assisted extraction of flavonoids from Crinum asiaticum

Yu, Man; Bing, Wang; Zheng, Qi; Xin, Guiliang; Li, Wenlan

doi:10.1016/j.sjbs.2019.09.018

Cited by 58 publications

(31 citation statements)

References 13 publications

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“…The nature of the extracting agent (solvent) will affect the type of flavonoid extracted and will directly influence the biological activity of the recovered compounds. Of the solvents tested, ethanol and methanol are the most widely used for the extraction of flavonoids due to higher yields achieved in the recovery of flavonoids [43,44]. The high demand for antioxidants gave way to the search for methodological alternatives that would increase the yield of flavonoid extraction and reduce process costs.…”

Section: Conventional Methodsmentioning

confidence: 99%

Conventional and Emerging Extraction Processes of Flavonoids

et al. 2020

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Flavonoids are a group of plant constituents called phenolic compounds and correspond to the nonenergy part of the human diet. Flavonoids are found in vegetables, seeds, fruits, and beverages such as wine and beer. Over 7000 flavonoids have been identified and they have been considered substances with a beneficial action on human health, particularly of multiple positive effects because of their antioxidant and free radical scavenging action. Although several studies indicate that some flavonoids have provident actions, they occur only at high doses, confirming in most investigations the existence of anti-inflammatory effects, antiviral or anti-allergic, and their protective role against cardiovascular disease, cancer, and various pathologies. Flavonoids are generally removed by chemical methods using solvents and traditional processes, which besides being expensive, involve long periods of time and affect the bioactivity of such compounds. Recently, efforts to develop biotechnological strategies to reduce or eliminate the use of toxic solvents have been reported, reducing processing time and maintaining the bioactivity of the compounds. In this paper, we review, analyze, and discuss methodologies for biotechnological recovery/extraction of flavonoids from agro-industrial residues, describing the advances and challenges in the topic.

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Section: Conventional Methodsmentioning

confidence: 99%

Conventional and Emerging Extraction Processes of Flavonoids

et al. 2020

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“…According to the single-factor study, the Box-Benhnken optimization study was designed ( Yu et al, 2019 ) with three levels (adsorption time, temperature, and pH). The adsorption ratio was chosen as inspection index.…”

Section: Methodsmentioning

confidence: 99%

Optimal extraction, purification and antioxidant activity of total flavonoids from endophytic fungi of Conyza blinii H. Lév

Zhao

Wu²,

Duan

et al. 2021

PeerJ

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Background Flavonoids are widely used in the market because of their antibacterial, antiviral, and antioxidant activities. But the production speed of flavonoids is limited by the growth of plants. CBL9 (Chaetomium cruentum) is a flavonoid-producing endophytic fungi from Conyza blinii H. Lév, which has potential to produce flavonoids. Methods In this study, we isolated total flavonoids from endophytic fungus CBL9 of Conyza blinii H. Lév using macroporous resin D101. The process was optimized by response surface and the best extraction process was obtained. The antioxidant activities of total flavonoids were analyzed in vitro. Results It was found that the best parameters were 25 °C pH 2.80, 1.85 h, and the adsorption ratio reached (64.14 ± 0.04)%. A total of 60% ethanol was the best elution solvent. The elution ratio of total flavonoid reached to (81.54 ± 0.03)%, and the purity was 7.13%, which was increased by 14.55 times compared with the original fermentation broth. Moreover its purity could rise to 13.69% after precipitated by ethanol, which is very close to 14.10% prepared by ethyl acetate extraction. In the antioxidant research, the clearance ratio of L9F-M on DPPH, ABTS, •OH, •O2−, (96.44 ± 0.04)% and (75.33 ± 0.03)%, (73.79 ± 0.02)%, (31.14 ± 0.01)% at maximum mass concentration, was higher than L9F. Conclusion The result indicated using macroporous resin in the extraction of total flavonoid from endophytic fungus is better than organic solvents with higher extraction ratio, safety and lower cost. In vitro testing indicated that the flavonoid extracted by macroporous resin have good antioxidant activity, providing more evidence for the production of flavonoid by biological fermentation method.

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“…This method is widely used to find levels of predictors that are thought to optimize the responses being studied. The advantage of the response surface method is that it does not require too much data so that the optimum response conditions can be obtained in not too long and the costs are minimum (Yu et al, 2019). In addition to the first-order modeling experiment, in conditions where the predictor is close to the response, the use of the second-order model is widely applied to approach the response state because of the curvature in its surface (Ajala et al, 2017).…”

Section: B Literature Reviewmentioning

confidence: 99%

“…Modeling in the response surface method uses the function of the second-order model because it is better at solving problems in the response surface. The response surface model for the second order is stated by (Yu et al, 2019).…”

Section: B Literature Reviewmentioning

confidence: 99%

Response Surface Regression with LTS and MM-Estimator to Overcome Outliers on Red Roselle Flowers

Lestari

Yuansa

2021

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The surface response method is similar to the regression analysis method which uses procedures or ways of estimating the response function regression model based on the Ordinary Least Square (OLS) method. Unfortunately, using the quadratic method has no drawbacks because it is easily sensitive to assumption deviations due to outlier cases. One of the solutions to the outlier problem is using robust regression. The method of parameters in the regression is very diverse, but the methods used in this study are the Least Trimmed Square (LTS) and MM-estimator methods because both methods have a high breakdown point of nearly 50%. The variables studied were the response variable consisting of red roselle plant height (Y1) and red roselle flower weight (Y2). While the independent variables were soil moisture factor (X1) and NPK fertilizer application factor (X2). The purpose of this study is to estimate the response surface regression parameters. using the LTS and MM-estimator methods on data that contains outliers. The resulting model in data analysis shows the same result that the best model is using the LTS estimation method. The modeling result of plant height obtained an R-Square value of 98,27% with an error is 1,243. Meanwhile, for the red rosella plant flower weight model, the R-Square value was 97,31% with an error is 0.6632.

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Response surface method was used to optimize the ultrasonic assisted extraction of flavonoids from Crinum asiaticum

Cited by 58 publications

References 13 publications

Conventional and Emerging Extraction Processes of Flavonoids

Conventional and Emerging Extraction Processes of Flavonoids

Optimal extraction, purification and antioxidant activity of total flavonoids from endophytic fungi of Conyza blinii H. Lév

Response Surface Regression with LTS and MM-Estimator to Overcome Outliers on Red Roselle Flowers

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