Respiratory syncytial virus infection and bronchial hyperreactivity in children up to two years of age in correlation with atopy

Relić, Tijana; Ilic, Nevenka; Kostić, Gordana; Jovanovic, Dara; Tambur, Zoran; Lazarević, Ivana

doi:10.2298/vsp140930030r

Cited by 4 publications

(8 citation statements)

References 33 publications

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“…The younger the age, the greater the risk of RSV infection, as corroborated by several authors, indicating a greater risk especially in children between 3 to 5 months [ 48 , 52 , 53 ], although other studies point out that RSV-associated hospitalizations reach their maximum peak in children under 3 months [ 54 ]. Other authors suggest a higher percentage of infection in children 0 to 12 months of age [ 45 , 54 , 55 , 56 , 57 , 58 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Risk Factors of Respiratory Syncytial Virus in Children under 5 Years of Age in the WHO European Region: A Systematic Review and Meta-Analysis

Suleiman‐Martos

Caballero-Vázquez

Gómez‐Urquiza

et al. 2021

JPM

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A respiratory syncytial virus (RSV) is the major cause of respiratory tract infection in children under 5 years. However, RSV infection in the European Region of the World Health Organization has not been systematically reviewed. The aim was to determine the prevalence and factors associated with RSV in children under 5 years of age in European regions. A systematic review and meta-analysis was performed. CINAHL, Medline, LILACS, ProQuest, SciELO, and Scopus databases were consulted for studies published in the last 5 years, following Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. The search equation was “respiratory syncytial virus AND (newborn OR infant OR child) AND (prevalence OR risk factors)”. Studies reporting the prevalence of RSV were eligible for inclusion in the meta-analysis. A total of 20 articles were included. The meta-analytic prevalence estimation of RSV, with a sample of n = 16,115 children, was 46% (95% CI 34–59%). The main risk factors were age, male gender, winter season, and environmental factors such as cold temperatures, higher relative humidity, high concentrations of benzene, exposure to tobacco, and living in urban areas. Robust age-specific estimates of RSV infection in healthy children should be promoted in order to determine the optimal age for immunization. In addition, it is necessary to analyse in greater depth the potentially predictive factors of RSV infection, to be included in prevention strategies.

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Section: Discussionmentioning

confidence: 99%

Prevalence and Risk Factors of Respiratory Syncytial Virus in Children under 5 Years of Age in the WHO European Region: A Systematic Review and Meta-Analysis

Suleiman‐Martos

Caballero-Vázquez

Gómez‐Urquiza

et al. 2021

JPM

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“…Respiratory syncytial virus (RSV) remains one of the most common pathogens in the world among young children (1,2). It has been previously reported that RSV is a serious threat to children with chronic lung disease, congenital heart disease or prematurity compared with healthy children (3,4).…”

Section: Introductionmentioning

confidence: 99%

LncRNA MEG3 ameliorates respiratory syncytial virus infection by suppressing TLR4 signaling

et al. 2017

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Maternally expressed gene 3 (MEG3), a long noncoding RNA (lncRNA) has been dysregulated in various tumors. However, the expression level and functional role of MEG3 in the progression of respiratory syncytial virus (RSV) infection remains to be elucidated. The present study quantified the expression level of MEG3 in the nasopharyngeal (NPA) samples of RSV‑infected patients and in BEAS‑2B cells infected with RSV. The findings of the present study demonstrated that the expression level of lncRNA MEG3 was reduced in the NPA samples of RSV‑infected patients and in BEAS‑2B cells infected with RSV. In vitro transfection revealed increased mRNA expression levels of toll‑like receptor 4 (TLR4), tumor necrosis factor‑α (TNFα) and interleukin (IL)‑8 following RSV infection in BEAS‑2B cells. Additionally, ectopic expression of MEG3 reduced the expression level of TLR4, subsequently suppressing the mRNA expression levels of TNFα and IL‑8, indicating the protective role of MEG3 in the process of RSV infection. It is of note, that RSV infection‑induced p38 mitogen activated protein kinase (MAPK) and nuclear factor‑κB (NF‑κB) activation was partly abolished by overexpression of MEG3. In conclusion, to the best of our knowledge, the present study provided the first evidence that lncRNA MEG3 expression level was reduced in the NPA samples of patients with RSV infection and RSV‑infected cells. Additionally, it was demonstrated that MEG3 protected human airway epithelial cells from RSV infection, primarily by suppressing TLR4‑dependent p38 MAPK and NF‑κB signaling.

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“…As for the causality between bronchiolitis and asthma, some possibilities have been proposed. Children with asthmatic characteristics may have susceptibility and more easier contract bronchiolitis [ 8 ]. On the other hand, bronchiolitis or early-life infections have been shown to influence the airway development, and further increase the risk of developing future asthma [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that the presence of recurrent wheeze in combination with allergic diseases and parental atopy helps in predicting later asthma [ 22 ]. Children with atopy seem to be prone to bronchiolitis, but relationships between bronchiolitis and allergic sensitization are often debated [ 7 , 8 , 17 , 25 , 26 , 27 ]. In our study, an interaction was demonstrated between atopic dermatitis and infant bronchiolitis regarding asthma risk ( Table 4 ).…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that some cases of infantile wheezing may progress to asthma [ 5 ]. Several factors such as recurrent wheezing, male sex, atopic diseases, and specific pathogens have been reported to contribute to asthma development in children with bronchiolitis [ 6 , 7 , 8 , 9 ]. However, there are currently no definitive conclusions about this causality [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Early Bronchiolitis Contributes to Preschool Asthma

Chang

Chiou

et al. 2021

Children

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This study aims to analyze whether bronchiolitis in children younger than one-year-old contributes to subsequent asthma. Medical data were retrieved from the National Health Insurance Research Database of Taiwan. Participants were divided into study (N = 65,559) and control (N = 49,656) groups, depending on whether they had early bronchiolitis. Incidences of asthma, potential comorbidities, and associated medical conditions were compared. The incidence of childhood asthma was significantly higher in the study group (aHR = 1.127, 95% CI: 1.063–1.195). Children with bronchiolitis hospitalization displayed higher asthma risk in the period between two and four years of age. The risk diminished as the children grew up. No relevant synergistic effects were found between bronchiolitis and atopic dermatitis. In conclusion, bronchiolitis before one year of age exhibits predictive value for development of preschool asthma, especially in children with bronchiolitis hospitalizations.

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Respiratory syncytial virus infection and bronchial hyperreactivity in children up to two years of age in correlation with atopy

Abstract: Children up to two years of age with atopy are more frequently infected with RSV (43.3%) than nonatopic children. Every third child with atopy develops BHR and 77.8% of them also have RSV infection. Atopic children are at higher risk for development of BHR when infected with RSV also.

Cited by 4 publications

References 33 publications

Prevalence and Risk Factors of Respiratory Syncytial Virus in Children under 5 Years of Age in the WHO European Region: A Systematic Review and Meta-Analysis

Prevalence and Risk Factors of Respiratory Syncytial Virus in Children under 5 Years of Age in the WHO European Region: A Systematic Review and Meta-Analysis

LncRNA MEG3 ameliorates respiratory syncytial virus infection by suppressing TLR4 signaling

Early Bronchiolitis Contributes to Preschool Asthma

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