Respiratory Granulomatosis with Polyarteritis Nodosa (Wegener's Syndrome)

Plummer, Norman; Angel, J. H.; Shaw, Doug; Hinson, K. F. W.

doi:10.1136/thx.12.1.57

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1958

2011

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Cited by 23 publications

(6 citation statements)

References 11 publications

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“…ADDENDUM.-Since this paper was written, I have seen further reports of cases of Wegener's granulomatosis by Fanger and Hoffman (1957), Plummer et al (1957), Levine and Madden (1957), Read and Treip (1957), Stoeckle et al (1957), andGordon et al (1957). …”

Section: Discussionmentioning

confidence: 85%

Giant-cell Granuloma of the Respiratory Tract (Wegener's Granulomatosis)

Walton¹

1958

BMJ

826

282

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Section: Discussionmentioning

confidence: 85%

Giant-cell Granuloma of the Respiratory Tract (Wegener's Granulomatosis)

Walton¹

1958

BMJ

826

282

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“…Plummer et al reported two cases of granulomatosis with polyangiitis and PAN in 1954; they described two patients with necrotising respiratory granulomatosis and concurrent PAN which they termed as Wegener’s syndrome. Both cases ended in patient mortality, one from renal failure and the other from respiratory failure 21. Another case report followed in 1957 by Read AE et al who reported the case of granuloma of the nose and systemic PAN 22…”

Section: Discussionmentioning

confidence: 98%

Systemic vasculitis: a dual diagnosis?

Gil

Lutalo²,

D’Cruz³

2011

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The authors describe a 25-year-old male with systemic vasculitis fulfilling the American College of Rheumatology classification criteria for both granulomatosis with polyangiitis (Wegener's granulomatosis) and polyarteritis nodosa. The patient was diagnosed with granulomatosis with polyangiitis following a mediastinal biopsy which revealed necrotising granulomas of the large airways, a positive cytoplasmic antineutrophil cytoplasmic antibodies and high antiproteinase 3 antibody titre. He then developed acute right-sided abdominal and testicular pain as well as areas of hyperaesthesia and parasthesiae on both lower limbs. He was found to have focal crescentic glomerulonephritis and mononeuritis multiplex, in keeping with his diagnosis of granulomatosis with polyangiitis, as well as two areas of infarction in his right testicle and multiple aneurysms of his hepatic and right renal arteries, more typical of polyarteritis nodosa. His symptoms developed 6 weeks after hepatitis B vaccination, which may have played an aetiological role.

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“…Less commonly, small soft foci or larger homogeneous infiltrations may occur, either alone, or in association with round, discrete nodules (Plummer, Angel, Shaw and Hinson, 1957;Leggatt and Walton, 1956). They may be transient, one appearing as another disappears.…”

Section: Radiologymentioning

confidence: 96%