Wegener's Granulomatosis—A Clinical and Radiological survey

McGregor, Mary B. B.; Sandler, Gerald

doi:10.1259/0007-1285-37-438-430

Cited by 34 publications

(6 citation statements)

References 8 publications

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“…Figures 5 and 6 5. CT scan of the maxillary sinuses of a 36-year-old man with a 14-year history of Wegener granulomatosis.…”

Section: Paling and Othersmentioning

confidence: 99%

“…It is characterized by necrotizing granubomatous vasculitis involving both the upper and lower respiratory tract, together with necrotizing glomerulonephritis (1,2). Reported bone changes in the sinuses have been limited to occasional destruction involving particularly the medial walls of the maxillary antra (5,8). Reported bone changes in the sinuses have been limited to occasional destruction involving particularly the medial walls of the maxillary antra (5,8).…”

mentioning

confidence: 99%

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Paranasal sinus obliteration in Wegener granulomatosis.

Paling¹,

Roberts²,

As³

1982

Radiology

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The authors report 14 cases of Wegener granulomatosis in which one or more paranasal sinuses were obliterated by bone. The maxillary antra were involved in all cases, with the other sinuses being affected less frequently. These changes are thought to result from chronic bacterial sinusitis superimposed on the granulomatous vasculitic process. Computed tomography dramatically demonstrated the bone changes, consisting of a combination of sinus wall thickening and trabeculated new bone formation within the sinuses.

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“…Figures 5 and 6 5. CT scan of the maxillary sinuses of a 36-year-old man with a 14-year history of Wegener granulomatosis.…”

Section: Paling and Othersmentioning

confidence: 99%

mentioning

confidence: 99%

Paranasal sinus obliteration in Wegener granulomatosis.

Paling¹,

Roberts²,

As³

1982

Radiology

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“…A normal chest radiograph is quite unusual in WG (4) but a figure as high as 50 per cent has been documented (8). Paranasal sinus radiographs revealed well described lesions (6,12).…”

Section: Discussionmentioning

confidence: 99%

“…Although a confirmed diagnosis requires histologic proof, a strong suggestion can be based on clinical and radiologic features (3,6,13). The radiologic findings are striking but not diagnostic of WG (6,8,10,11,12,15). They resemble those of tuberculosis, and in areas with a high prevalence of tuberculosis many patients with WG are not identified and treated at an early stage (7,13).…”

mentioning

confidence: 99%

Wegener's Granulomatosis in North India

Bambery¹,

Katariya²,

Sakhuja³

et al. 1988

Acta Radiol

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The chest radiograph in Wegener's granulomatosis reveals several striking, but not pathognomonic abnormalities. Nine (82%) of eleven patients with Wegener's granulomatosis had abnormal chest radiographs. Infiltrates were seen in all patients and were nodular in seven (77%). Six patients had cavities which were most often unilateral and thick walled. Serial radiographs showed the simultaneous appearance and resolution of infiltrates in 4 of 7 instances. Bilateral pulmonary involvement (67%), pleural effusion (33%), and pericardial effusion (22%) were also seen. Paranasal sinus involvement was seen in 4 of 5 studies. The chest radiograph was interpreted as tuberculosis in eight patients, resulting in delayed diagnosis and incorrect treatment.

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“…5 Responses to corticosteroids were found to be unpredictable, often unsuccessful, and frequently the corticosteroid contributed to the worsening of an infection. [5][6][7][8] Inevitably, death seemed to occur from renal failure or infection. Among 61 cases of WG seen at the University of California, Los Angeles (UCLA) and its affiliated hospitals from 1965 to 1986 (Tables 1,2), only 17% of those not receiving corticosteroids required hospitalization for infection, but they were also in much better overall health than the corticosteroid-treated group, of whom 53% were hospitalized for infections.…”

Section: Corticosteroidsmentioning

confidence: 99%