Respiratory damage caused by long-term inhalation of high concentration of sulphur-dioxide in dogs

Islam, M. S.; Oellig, W. P.; Weller, W.

doi:10.1007/bf01851505

Cited by 6 publications

(2 citation statements)

References 12 publications

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“…Existing data from experimental animal studies with oxidizing air pollutants like NO2 have shown that chronic inhalation leads to serious morphological lesions especially in the lung periphery (1) whereas SO2, for example, does not seem to have such effects or only at higher concentrations (2,3).…”

Section: Introductionmentioning

confidence: 99%

Effects of NO 2 on Chronic Bronchitics

Nieding¹,

Wagner²

1979

Environmental Health Perspectives

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The acute influence of NO2 on mechanics of breathing and respiratory gas exchange was investigated in a total of 111 subjects, aged 25 to 74 years, with chronic nonspecific lung disease (CNSLD). They breathed NO2-air mixtures containing 0.5 to 8.0 ppm NO2 for up to 15 to 60 min. Additionally in nine subjects the protective action of atropine, meclastine, and orciprenaline was investigated.While the alveolar P02 remained nearly constant during inhalation of 5 and 4 ppm NO2, a significant decrease of the arterial P02 and a corresponding increase of the arterial to alveolar P02 gradients occurred. Inhalation of 2 ppm NO2 had not such an effect.Inhalation of NO2 at concentrations down to 1.5 ppm resulted in a significant increase of airway resistance. Lower concentrations had no significant effect.Prolongation of the exposure period from 15 to 60 min at a NO2 concentration of 5 ppm did not result in a more pronounced disturbance of the respiratory gas exchange for oxygen beyond the extent observed after exposure to 5 ppm NO2 for 15 min.Meclastine, in comparison with orciprenaline and atropine, showed a pronounced protective effect on the negative impact of NO2 on respiratory gas exchange and airway resistance.It is concluded that NO2 may act by release of histamine, causing a bronchiolar, alveolar, and interstitial edema, thus differing from irritant air pollutants like SO2, where reflex bronchoconstriction causes in some bronchitics dramatic increases of airway resistance at similar low concentrations.

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Section: Introductionmentioning

confidence: 99%

Effects of NO 2 on Chronic Bronchitics

Nieding¹,

Wagner²

1979

Environmental Health Perspectives

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show abstract

Section: Introductionmentioning

confidence: 99%

Effects of NO2 on chronic bronchitics.

Nieding¹,

Wagner²

1979

Environ Health Perspect

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The acute influence of NO2 on mechanics of breathing and respiratory gas exchange was investigated in a total of 111 subjects, aged 25 to 74 years, with chronic nonspecific lung disease (CNSLD). They breathed NO2-air mixtures containing 0.5 to 8.0 ppm NO2 for up to 15 to 60 min. Additionally in nine subjects the protective action of atropine, meclastine, and orciprenaline was investigated. While the alveolar PO2 remained constant during inhalation of 5 and 4 ppm NO2, a significant decrease of the arterial PO2 and a corresponding increase of the arterial to alveolar PO2 gradients occurred. Inhalation of 2 ppm NO2 had not such an effect. Inhalation of NO2 at concentrations down to 1.5 ppm resulted in a significant increase of airway resistance. Lower concentrations had no significant effect. Prolongation of the exposure period from 15 to 60 min at a NO2 concentration of 5 ppm did not result in a more pronounced disturbance of the respiratory gas exchange for oxygen beyond the extent observed after exposure to 5 ppm NO2 for 15 min. Meclastine, in comparison with orciprenaline and atropine, showed a pronounced protective effect on the negative impact of NO2 on respiratory gas exchange and airway resistance. It is concluded that NO2 may act by release of histamine, causing a bronchiolar, alveolar, and interstitial edema, thus differing from irritant air pollutants like SO2, where reflex bronchoconstriction causes in some bronchitics dramatic increases of airway resistance at similar low concentrations.

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