Effects of NO2 on chronic bronchitics.

Nieding, Gerhild; Wagner, H

doi:10.1289/ehp.7929137

Cited by 12 publications

(2 citation statements)

References 23 publications

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“…This is supported by the finding that plasma histamine and LDH3 are not significantly changed. A decrease in histamine has been demonstrated in the lungs of mice and rats exposed to oxidants (16)(17)(18), whereas increased levels of plasma LDH3 are suggested to be indicative of lung tissue damage (19).…”

Section: Methodsmentioning

confidence: 99%

Distinct Enzymatic Responses in Mice Exposed to a Range of Low Doses of Ozone

Veninga¹,

Wagenaar²,

Lemstra³

1981

Environmental Health Perspectives

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Short-term exposure of mice to low 03 doses, as defined by the product of concentration and exposure time (ct), was observed to induce alterations in two enzyme systems: first, that leading to changes in hepatic reduced ascorbic acid (RAA) content, and second to changes in plasma creatine phosphokinase (CPK) activity. RAA alterations were noticed immediately, 30 min and 120 min after termination of the exposure period, whereas CPK showed alterations immediately and 15 min after termination of the exposure. Later determinations, i.e., 24 hr after 03 exposure for RAA and 30 min after 03 exposure for CPK, revealed no significant differences when compared to control animals. Although differences in sensitivity existed, the dose response curves for both systems were more or less similar, showing a short decrease for the initial very low 03 doses, followed by a profound rise and a gradual decrease to control levels for subsequent ct doses. Exceptions were the 30 min curve for RAA and the immediate curve for CPK in so far as that both showed an additional depression.Neither plasma histamine nor plasma lactic acid dehydrogenase (LDH3) were observed to be altered by the range of 03 doses employed. These findings were explained on the basis of adaptation of the organism to a potentially noxious 03 stimulus by enhanced metabolic processes: a weak stimulus leading to only a small adjustment, and stronger stimuli to elevated enzyme activity as well. With increasing doses of 03 this elevation in enzyme activity was found to be gradually diminished, possibly due to a steadily growing demand, leaving the overshoot becoming continually smaller until a balanced state is achieved.Radiomimetic activity of ozone (03), first described by Brinkman and Lamberst (1) (5, 6). In the opinion of these authors there is no threshold value (no-effect level), and the dose-effect curve starts at zero. However, in the same way as with ionizing irradiation, in order to visualize effects, dosages of 03 have to be explored which in general clearly exceed the permissible

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Section: Methodsmentioning

confidence: 99%

Distinct Enzymatic Responses in Mice Exposed to a Range of Low Doses of Ozone

Veninga¹,

Wagenaar²,

Lemstra³

1981

Environmental Health Perspectives

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“…Linn et al [ 19] [38] 111 no statistically significant changes in pulmo-XXX nary mechanics or symptoms in subjects with chronic obstructive pulmonary disease 1 h, including 2 x 15 min of exercise 0.5 ppm 1.0 ppm 2.0 ppm Linn et al [39] 22…”

Section: Experimental Clinical Studies Of Patients With Lung Diseasesmentioning

confidence: 98%

Nitrogen Dioxide: Causation and Aggravation of Lung Diseases

Ström¹,

Alfredsson²,

Malmfors³

et al. 1994

Indoor Built Environ

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It is of great importance to investigate the role of air pollutants in causing and aggravating lung diseases. The levels of concentration of some of these combustion products have shown a decreasing emission curve, but the emissions of nitrogen dioxide (NO(2)) are still increasing. Most of the NO2 emissions originate from road traffic. The installation of catalytic converters may well change this. It is established that low concentrations of NO2 affect the respiratory system; this is especially obvious in asthmatics. Regarding long-term effects, it is believed that high levels of NO(2) may cause an increased frequency of respiratory illness, but it is not possible to confirm this suspicion completely.

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Smoking and Health

Berton¹,

Odom²

1980

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Effects of NO2 on chronic bronchitics.

Cited by 12 publications

References 23 publications

Distinct Enzymatic Responses in Mice Exposed to a Range of Low Doses of Ozone

Distinct Enzymatic Responses in Mice Exposed to a Range of Low Doses of Ozone

Nitrogen Dioxide: Causation and Aggravation of Lung Diseases

Smoking and Health

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