Resource Utilization and Outcomes of Infective Endocarditis in Children

Ware, Adam L.; Tani, Lloyd Y.; Weng, Hsin-Yi; Wilkes, Jacob; Menon, Shaji C.

doi:10.1016/j.jpeds.2014.06.026

Cited by 36 publications

(20 citation statements)

References 20 publications

(20 reference statements)

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“…Because of a decrease in the incidence of RHD-associated heart valve diseases in children in developed countries, IE usually develops secondary to CHD [ 3 - 5 ] . However, in these countries, while there has been a decrease in the number of patients with underlying RHD-associated heart valve disease, there has been a significant increase in the incidence of prosthetic valve endocarditis [ 6 , 7 ] . Reportedly, IE involvement in native pulmonary valve is very rare [ 8 , 9 ] .…”

Section: Discussionmentioning

confidence: 99%

Infective Endocarditis in Childhood: a SingleCenter Experience of 18 Years

Yakut

Ecevit

Tokel

et al. 2021

Braz J Cardiovasc Surg

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Introduction We aimed to present the risk factors, clinical and laboratory findings, treatment management, and risk factors for morbidity and mortality of infective endocarditis (IE) as well as to relate experiences at our center. Method We retrospectively analyzed data of 47 episodes in 45 patients diagnosed with definite/possible IE according to the modified Duke criteria between May 2000 and March 2018. Results The mean age of all patients at the time of diagnosis was 7.6±4.7 years (range: 2.4 months to 16 years). The most common symptoms and findings were fever (89.3%), leukocytosis (80.8%), splenomegaly (70.2%), and a new heart murmur or changing of pre-existing murmur (68%). Streptococcus viridans (19.1%), Staphylococcus aureus (14.8%), and coagulase-negative Staphylococci (10.6%) were the most commonly isolated agents. IE-related complications developed in 27.6% of the patients and the mortality rate was 14.8%. Conclusion We found that congenital heart disease remains a significant risk factor for IE. The highest risk groups included operated patients who had conduits in the pulmonary position and unoperated patients with a large ventricular septal defect. Surgical intervention was required in most of the patients. Mortality rate was high, especially in patients infected with S. aureus , although the time between the onset of the first symptom and diagnosis was short. Patients with fever and a high risk of IE should be carefully examined for IE, and evaluation in favor of IE until proven otherwise will be more accurate. In high-risk patients with prolonged fever, IE should be considered in the differential diagnosis.

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Section: Discussionmentioning

confidence: 99%

Infective Endocarditis in Childhood: a SingleCenter Experience of 18 Years

Yakut

Ecevit

Tokel

et al. 2021

Braz J Cardiovasc Surg

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“…Infection of placed catheter and nosocomial infection may also be caused by gram-negative bacteria and fungi. 4,197,256…”

Section: Management Of Specific Situationsmentioning

confidence: 99%

JCS 2017 Guideline on Prevention and Treatment of Infective Endocarditis

Nakatani

Ohara

Ashihara

et al. 2019

Circ J

128

166

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“…Щорічна захворюваність на ІЕ коливається від 0,05 до 0,12 випадку на 1000 педіатричних госпіталізацій [2,3]. Рівень смертності в загальній групі хворих з ІЕ становить майже 5 % [4]. Rushani D. та співавт.…”

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Experience of surgical treatment of infective endocarditis in children

Prokopovуch¹,

Golovenko

Truba

et al. 2019

ccs

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Surgical treatment of infectious endocarditis in children, single-center experience. The paper analyzes the experience of surgical treatment of infectious endocarditis (IE) in children. In the period from January 1999 to July 2019, 69 children with IE were operated at National Amosov Institute of Cardiovascular Surgery of NAMS of Ukraine, 44 of them (63.8%) developed the disease on the background of congenital heart defects (CHD). The mean age of the patients at the time of surgery was 9.1 ± 6.1 years. The average weight is 31.5 ± 21.7 (3.6 to 85 kg). The duration of the disease at the time of hospitalization was 5.3 ± 1.1 months. The average duration of the fever before hospitalization was 10.2 ± 8.5 weeks. Among the causes of IE, we observed three groups of inflammatory diseases: infections of the skin and subcutaneous fat in 15 (21.7%) cases, pathology of ENT – organs – 14 (20.2%) and broncho-pulmonary diseases – 9 (13.1%) cases. The risk factors were: presence of CHD – 44 (63.7%) and also nosocomial factors. The microbiological spectrum of pathogens included gram-positive microorganisms – 33 (71.7%), gram-negative microorganisms 4 (8.7%) and fungal microflora 9 (19.6%). The mean values of bypass circulation were 111.5 ± 62.4 minutes, and the time of aortic clamping was 71.4 ± 43.9 minutes, respectively. Hospital mortality in the general group of patients was 4 (5.8%) cases. In the follow-up period, 59 patients were examined, representing 90.7% of those discharged at the hospital stage. The observation period lasted from one month to 19.4 years (9.6 ± 5.7 years). According to the Kaplan-Meier analysis, the cumulative survival rate of patients in the CHD group at one year after surgery was 97.1%, at 10 years – 93.5%; after 15 years – 93.5%. Survival in the non-CHD group at 5, 10, and 15 years was 100%. In the long term, two patients died (3.4%). The recurrence rate of IE in the distant period was 2 (3.4%) cases. The incidence of long-term reoperation was 8 (13.6%) cases, three were recurrent IE and five were non-recurrent. According to Kaplan-Meier analysis, the proportion of patients without recurrent surgery in the long-term follow-up at 5 years was 87.9%, at 10 years – 84.1%, after 15 years – 77.1% in the CHD group. In the group without CHD 5 years – 95.2%, 10 years – 95.2%, 15 years – 81.6%. In the long term, as a result of performed surgical interventions, the regression of clinical manifestations of heart failure was noted in the majority of patients.

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Resource Utilization and Outcomes of Infective Endocarditis in Children

Cited by 36 publications

References 20 publications

Infective Endocarditis in Childhood: a SingleCenter Experience of 18 Years

Infective Endocarditis in Childhood: a SingleCenter Experience of 18 Years

JCS 2017 Guideline on Prevention and Treatment of Infective Endocarditis

Experience of surgical treatment of infective endocarditis in children

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