Resorptionsprozesse als Quelle der Formbildung

Blacher, L. J.; Irichimowitsch, A. I.; Liosner, L. D.; Woronzowa, M. A.

doi:10.1007/bf01390722

Cited by 6 publications

(1 citation statement)

References 3 publications

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“…The scope of their scientific interest within the field of animal regeneration was extremely diverse. Initially, the model choice was confined to limb regeneration in amphibians, with the main focus on the balance of destruction and proliferation and the role of mitogenic radiation in these processes; a series of such studies was published in the Wilhelm Roux' Archiv für Entwicklungsmechanik der Organismen (Blacher et al, 1933;Liosner et al, 1936). Later on, the focus of scientific interest eventually shifted toward the regeneration of internal organs, notably parenchymal organs, in amphibians and ultimately in mammals.…”

Section: Contribution Of Russian Scientists To the Theory Of Regeneramentioning

confidence: 99%

Evolution of Regeneration in Animals: A Tangled Story

2021

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The evolution of regenerative capacity in multicellular animals represents one of the most complex and intriguing problems in biology. How could such a seemingly advantageous trait as self-repair become consistently attenuated by the evolution? This review article examines the concept of the origin and nature of regeneration, its connection with the processes of embryonic development and asexual reproduction, as well as with the mechanisms of tissue homeostasis. The article presents a variety of classical and modern hypotheses explaining different trends in the evolution of regenerative capacity which is not always beneficial for the individual and notably for the species. Mechanistically, these trends are driven by the evolution of signaling pathways and progressive restriction of differentiation plasticity with concomitant advances in adaptive immunity. Examples of phylogenetically enhanced regenerative capacity are considered as well, with appropriate evolutionary reasoning for the enhancement and discussion of its molecular mechanisms.

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Section: Contribution Of Russian Scientists To the Theory Of Regeneramentioning

confidence: 99%