Evolution of Regeneration in Animals: A Tangled Story

Elchaninov, Andrey; Сухих, Г. Т.; Fatkhudinov, Timur

doi:10.3389/fevo.2021.621686

Cited by 25 publications

(29 citation statements)

References 129 publications

(206 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regeneration capacity is shared to a variable extent by all living organisms [ 21 ]. Repair processes in mammals follow certain patterns (including both advantages and limitations) not observed in other multicellular animals.…”

Section: Discussionmentioning

confidence: 99%

MARCO+ Macrophage Dynamics in Regenerating Liver after 70% Liver Resection in Mice

et al. 2021

Self Cite

View full text Add to dashboard Cite

Background: Macrophages play a key role in liver regeneration. The fates of resident macrophages after 70% resection are poorly investigated. In this work, using the MARCO macrophage marker (abbreviated from macrophage receptor with collagenous structure), we studied the dynamics of mouse liver resident macrophages after 70% resection. Methods: In BALB/c male mice, a model of liver regeneration after 70% resection was reproduced. The dynamics of markers CD68, TIM4, and MARCO were studied immunohistochemically and by using a Western blot. Results: The number of MARCO- and CD68-positive macrophages in the regenerating liver increased 1 day and 3 days after resection, respectively. At the same time, the content of the MARCO protein increased in the sorted macrophages of the regenerating liver on the third day. Conclusions: The data indicate that the number of MARCO-positive macrophages in the regenerating liver increases due to the activation of MARCO synthesis in the liver macrophages. The increased expression of MARCO by macrophages can be regarded as a sign of their activation. In the present study, stimulation with LPS led to an increase in the expression of the Marco gene in both Kupffer cells and macrophages of bone marrow origin.

show abstract

Section: Discussionmentioning

confidence: 99%

MARCO+ Macrophage Dynamics in Regenerating Liver after 70% Liver Resection in Mice

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Deciphering the underlying mechanisms of tissue regeneration across phylogeny requires the integrative knowledge of evolutionary biology since the trait (regeneration) changes over the course of evolution (Zattara et al, 2019). This phenomenon is due to the fact that maintaining regenerative capacities requires selective pressures, in terms of the frequency and severity of major damages in an extreme living environment (Morgan, 1901;Lin et al, 2017;Elchaninov et al, 2021). These damages may compromise the fitness of the organisms, but they are not always detrimental for survival and propagation as a selective pressure (Fox and McCoy, 2000;Bernardo and Agosta, 2005).…”

Section: Evolution Of the Regenerative Capacitymentioning

confidence: 99%

“…of organs (Elchaninov et al, 2021). In addition, the loss of capacity in myocardial regeneration in adult mammals could be an evolutionary trade-off related to energy metabolism (Elhelaly et al, 2016).…”

Section: Evolution Of the Regenerative Capacitymentioning

confidence: 99%

“…In the Kingdom Animalia, the loss of regenerative ability coincides with the evolution of new and complex cell and tissue types (Brockes et al, 2001;Maginnis, 2006;Bely and Nyberg, 2010;Elchaninov et al, 2021). Anatomically simple organisms, such as hydra and planarians, can regenerate their entire body when cut into multiple pieces (Reddien and Alvarado, 2004;Reddy et al, 2019).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Comparative Study in Zebrafish and Medaka Unravels the Mechanisms of Tissue Regeneration

2022

View full text Add to dashboard Cite

Tissue regeneration has been in the spotlight of research for its fascinating nature and potential applications in human diseases. The trait of regenerative capacity occurs diversely across species and tissue contexts, while it seems to decline over evolution. Organisms with variable regenerative capacity are usually distinct in phylogeny, anatomy, and physiology. This phenomenon hinders the feasibility of studying tissue regeneration by directly comparing regenerative with non-regenerative animals, such as zebrafish (Danio rerio) and mice (Mus musculus). Medaka (Oryzias latipes) is a fish model with a complete reference genome and shares a common ancestor with zebrafish approximately 110–200 million years ago (compared to 650 million years with mice). Medaka shares similar features with zebrafish, including size, diet, organ system, gross anatomy, and living environment. However, while zebrafish regenerate almost every organ upon experimental injury, medaka shows uneven regenerative capacity. Their common and distinct biological features make them a unique platform for reciprocal analyses to understand the mechanisms of tissue regeneration. Here we summarize current knowledge about tissue regeneration in these fish models in terms of injured tissues, repairing mechanisms, available materials, and established technologies. We further highlight the concept of inter-species and inter-organ comparisons, which may reveal mechanistic insights and hint at therapeutic strategies for human diseases.

show abstract

“…The ability to regenerate structures is widely distributed throughout the animal kingdom including vertebrates and invertebrates (Brockes and Kumar, 2008;Daponte et al, 2021;Elchaninov et al, 2021). Accordingly, understanding the mechanisms underlying this regenerative capacity has become one of the major challenges in developmental and regenerative biology, with the firm purpose of providing new insights and directions for the development of new therapies in the field of regenerative medicine (Brockes and Kumar, 2005;Poss, 2010;Dolan et al, 2018;Iismaa et al, 2018;Arenas Gómez and Echeverri, 2021;Grigoryan, 2021).…”

Section: Introductionmentioning

confidence: 99%

Post-amputation reactive oxygen species production is necessary for axolotls limb regeneration

Carbonell-M

Cardona

Delgado

2022

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Introduction: Reactive oxygen species (ROS) represent molecules of great interest in the field of regenerative biology since several animal models require their production to promote and favor tissue, organ, and appendage regeneration. Recently, it has been shown that the production of ROS such as hydrogen peroxide (H2O2) is required for tail regeneration in Ambystoma mexicanum. However, to date, it is unknown whether ROS production is necessary for limb regeneration in this animal model. Methods: forelimbs of juvenile animals were amputated proximally and the dynamics of ROS production was determined using 2′7- dichlorofluorescein diacetate (DCFDA) during the regeneration process. Inhibition of ROS production was performed using the NADPH oxidase inhibitor apocynin. Subsequently, a rescue assay was performed using exogenous hydrogen peroxide (H2O2). The effect of these treatments on the size and skeletal structures of the regenerated limb was evaluated by staining with alcian blue and alizarin red, as well as the effect on blastema formation, cell proliferation, immune cell recruitment, and expression of genes related to proximal-distal identity. Results: our results show that inhibition of post-amputation limb ROS production in the A. mexicanum salamander model results in the regeneration of a miniature limb with a significant reduction in the size of skeletal elements such as the ulna, radius, and overall autopod. Additionally, other effects such as decrease in the number of carpals, defective joint morphology, and failure of integrity between the regenerated structure and the remaining tissue were identified. In addition, this treatment affected blastema formation and induced a reduction in the levels of cell proliferation in this structure, as well as a reduction in the number of CD45+ and CD11b + immune system cells. On the other hand, blocking ROS production affected the expression of proximo-distal identity genes such as Aldha1a1, Rarβ, Prod1, Meis1, Hoxa13, and other genes such as Agr2 and Yap1 in early/mid blastema. Of great interest, the failure in blastema formation, skeletal alterations, as well as the expression of the genes evaluated were rescued by the application of exogenous H2O2, suggesting that ROS/H2O2 production is necessary from the early stages for proper regeneration and patterning of the limb.

show abstract

Evolution of Regeneration in Animals: A Tangled Story

Cited by 25 publications

References 129 publications

MARCO+ Macrophage Dynamics in Regenerating Liver after 70% Liver Resection in Mice

MARCO+ Macrophage Dynamics in Regenerating Liver after 70% Liver Resection in Mice

Comparative Study in Zebrafish and Medaka Unravels the Mechanisms of Tissue Regeneration

Post-amputation reactive oxygen species production is necessary for axolotls limb regeneration

Contact Info

Product

Resources

About