Mitogenetic rays and wound healing

Dimethyl Sulfoxide: Influence Upon Frog Tadpole Metamorphosis

“…Any explanation of the apparent failure of DMSO to counteract thyroxin's acceleration of the metamorphosis of R. clamitans larvas, particularly the phenomenon of tail involution, cannot be derived directly from the current investigation. The regression of the larval anuran tail represents degenerative changes; in contrast, the emergence of the forelimbs represents continued growth of the anterior appendages and a simultaneous degeneration of the operculum [Helff, 1924 and1926a]. Hammerman [1964] reported a continuation of growth processes in a study of thiocarbamide treatment as it affects larval anuran tongue regeneration and histogenesis.…”

“…It is known that thyroid hormone raises the rate of metabolism in mammals, and that thyroxin and triiodothyronine both increase oxygen consumption in tadpoles [Helff, 1926b]. Antithyroid agents, on the other hand, decrease the basal metabolic rate, and this decrease can be counteracted by administration of thyroid substance.…”