Resolution of recalcitrant molluscum contagiosum virus lesions in human immunodeficiency virus-infected patients treated with cidofovir

Intravenous cidofovir-induced resolution of disfiguring cutaneous human papillomavirus infection

“…26,27 In the trial of Snoek et al, 26 47% of patients showed a complete response and none progressed, compared with no complete response and 45% with progression in the placebo group. Cidofovir has been used both IV and topically for molluscum contagiosum, 28 topically for mucocutaneous herpes simplex virus 29 and bowenoid papulosis of the penis, 30 and intralesionally for recurrent laryngeal papillomatosis. [31][32][33] To date, there has been only one report of IV cidofovir, to our knowledge, for the treatment of HPV infection.…”

Vaccines and immunotherapies for the prevention of infectious diseases having cutaneous manifestations

“…Although cidofovir has never been used to treat vaccinia infections in human beings, the first use of cidofovir in 3 HIV-positive men with recurrent molluscum contagiosum virus cleared the lesions. 23 These were the first documented cases in which cidofovir was used to treat poxvirus infections in human beings.…”

5. Imiquimod 5% Cream for the Treatment of Cutaneous Lesions in Immunocompromised Patients

“…The first takes the form of treating the HIV disease itself irrespective of the patient's immune status e.g. treatment of VZV with systemic acyclovir or famcyclovir or the use of interlesional interferons (IFNs) (1,4,5). Alternatively, the HIV can be directly targeted through highly active anti-retroviral therapy (HAART) (6).…”