Intravenous cidofovir-induced resolution of disfiguring cutaneous human papillomavirus infection

British Association of Dermatologists' guidelines for the management of cutaneous warts 2014

“…The effect of acitretin 0Á5-1 mg kg À1 per day for up to 3 months is usually a reduction in the bulk of lesions, but with a high risk of recurrence on discontinuation of therapy. 113 In an observational study of children aged [116][117][118][119][120] but it is generally used topically. Topical cidofovir is reconstituted from the parenteral form, as either a 1% or 3% cream.…”

Intravenous cidofovir for resistant cutaneous warts in a patient with psoriasis treated with monoclonal antibodies

“…Kottke et al. 5 described clearance of facial warts in a patient with HIV, despite a persistently low CD4 count and high viral loads. Cusack et al.…”

“…A 21-year-old patient who was immunosuppressed secondary to myelodysplastic syndrome and chemotherapy, had resolution of extensive, widespread warts with cidofovir given over 18 weeks. 4 Kottke et al 5 described clearance of facial warts in a patient with HIV, despite a persistently low CD4 count and high viral loads. Cusack et al 6 reported an 11-year-old girl successfully treated with cidofovir for recalcitrant warts.…”

“…Cidofovir is licensed for treatment of resistant cytomegalovirus (CMV) retinitis in patients with human immunodeficiency virus (HIV), but has broad‐spectrum activity against DNA viruses 2 . It has been successfully used in a limited number of cutaneous (HPV) infections 3–6 …”

Successful Treatment of Acyclovir-Resistant Herpes Simplex Virus With Intralesional Cidofovir

“…There is a precedent for using topical cidofovir, 1% and 3%, in dermatology for cutaneous HSV,5 human papillomavirus,6 and molluscum contagiosum 7. Intravenous cidofovir is also used in patients with acyclovir-resistant HSV skin disease 8,9. We decided that IL therapy would provide a more efficient and direct source of medication for this patient’s lesions because his response to the IV cidofovir seemed to be waning.…”