Reshaping the Inflammatory Environment in Rheumatoid Arthritis Joints by Targeting Delivery of Berberine with Platelet‐Derived Extracellular Vesicles

Ma, Qingle; Bai, Jinyu; Xu, Jun; Dai, Huaxing; Fan, Qing‐Hua; Fei, Ziying; Chu, Jiacheng; Yao, Chenlu; Shi, Haoliang; Zhou, Xiaozhong; Lin, Boqiang; Wang, Chao

doi:10.1002/anbr.202100115

Cited by 11 publications

(9 citation statements)

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“…Efforts are underway to develop techniques for predicting the onset of RA and T 1 D (Raychaudhuri et al., 2017 ; Yi et al., 2018 ; Harms et al., 2020 ; Su, 2020 ). Moreover, RA therapies based on the cellular delivery systems are on the rise (Q. Zhang et al., 2018 ; Q. Ma et al., 2021 ), and the application of myelin whole antigen is overcoming the barrier to clinical translation of MS animal models (Casella et al., 2020 ). In addition, the widespread vaccination of Comirnaty and Spikevax for coronavirus disease 2019 (COVID-19) prevention in the population further verifies the safety and effectiveness of LNP technology (Thompson et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory nano-preparations for rheumatoid arthritis

Han

Luo³

et al. 2022

Drug Delivery

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Rheumatoid arthritis (RA) is a systemic autoimmune disease (AD) caused by the aberrant attack of the immune system on its own joint tissues. Genetic and environmental factors are the main reasons of immune system impairment and high incidence of RA. Although there are medications on the market that lessen disease activity, there is no known cure for RA, and patients are at risk in varying degrees of systemic immunosuppression. By transporting (encapsulating or surface binding) RA-related self-antigens, nucleic acids, immunomodulators, or cytokines, tolerogenic nanoparticles—also known as immunomodulatory nano-preparations—have the potential to gently regulate local immune responses and ultimately induce antigen-specific immune tolerance. We review the recent advances in immunomodulatory nano-preparations for delivering self-antigen or self-antigen plus immunomodulator, simulating apoptotic cell avatars in vivo , acting as artificial antigen-presenting cells, and based on scaffolds and gels, to provide a reference for developing new immunotherapies for RA.

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Section: Discussionmentioning

confidence: 99%

Immunomodulatory nano-preparations for rheumatoid arthritis

Han

Luo³

et al. 2022

Drug Delivery

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“…The existence of bacteria in the brain tissue results in the disruption of brain homeostasis, especially for astrocytes and microglia. Platelet-derived extracellular vesicles (PEVs) could serve as a general platform for inflammatory cells targeting drug delivery, which has been demonstrated by our group in previous studies [15][16][17][18] . By loading rapamycin into PEVs (rapamycin-PEVs), we showed that intranasal delivery of rapamycin-PEVs rescued the dysfunction of astrocytes and microglia caused by severe acute pneumonia, effectively alleviated the neurological disorders after pneumonia.…”

Section: Introductionmentioning

confidence: 86%

“…As the rapamycin we used here was relatively insoluble and unstable (Figure 6A), its distribution in the brain was quite limited by intravenous injection in our preliminary data (data not shown). In our previous studies, we demonstrated that platelet-derived extracellular vesicles (PEVs) could serve as a universal platform to selectively target various inflammatory cells and tissues [15][16][17][18] (Figure 6C). To effectively deliver rapamycin to the brain, PEVs were used as carriers for direct nasal delivery of rapamycin, which is an effective and reliable way to bypass the blood-brain barrier and deliver drugs into the central nervous system 35 .…”

Section: Rapamycin Rescues Brain Homeostasis and Neurological Disordersmentioning

confidence: 99%

Neurological Disorder after Severe Pneumonia is Associated with Translocation of Bacteria from Lung to Brain

Yao

Wang

et al. 2022

Preprint

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Neurological disorders after severe acute pneumonia have been attacked much attention in recent years. However, the underline mechanisms remain not very clear. Here we show that these neurological syndromes after severe acute pneumonia are partly attributed to the translocation of bacteria from the lung to the brain during acute pneumonia. We detected an emerging and increased bacteria in the brain tissue of mice with lipopolysaccharide-induced experimental severe pneumonia. Interestingly, using 16S rDNA amplification sequencing, similarities were found between the brain's flora species and those of the lungs, indicating the bacteria in the brain may come from the lung. We also observed the impairment of the lung-blood barrier and brain-blood barrier, simultaneously, allowing lung bacteria invade the brain during pneumonia. An elevated microglia and astrocytes activation markers signature though bacterial infection-related pathways are observed by single-cell RNA sequencing, indicating a bacteria-induced disruption of brain homeostasis. Rapamycin delivered by platelet-derived extracellular vesicles provides an effective strategy to rescue the brain microenvironment and neurological disorders. Collectively, we identify lung bacteria that play a role in altering brain homeostasis, which provides new insight into the mechanism of neurological syndromes after severe pneumonia.

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“…The mature megakaryocytes in bone marrow can separate into small pieces of cytoplasm, eventually forming platelets, 157,158 could clot and stop bleeding and repair damaged blood vessels in vivo. Platelets can repair peripheral nerves by secreting a variety of growth factors.…”

Section: Differentiated Cell Deliverymentioning

confidence: 99%

Recent advances in 3D printing hydrogel for topical drug delivery

Zhang

Wang

2022

MedComm – Biomaterials and Applications

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Polymer hydrogel has been used as a drug delivery carrier for many decades. Recently, the emergence of three‐dimensional (3D) printing technology has opened up a new area for applications of drug delivery based on polymer hydrogel. A series of drug delivery platforms based on 3D printing hydrogel are developed to achieve local delivery of small/large molecule drugs as well as therapeutic cells. Compared with other manufacturing technologies, 3D printing technology can achieve high‐precision personalized manufacturing and complex spatial structure construction, which has a wide application prospect in the biomedical field. In this review, we summarized the recent advances in 3D printed polymer hydrogels as delivery platforms in drug and cell topical delivery. 3D printed drug delivery platform realizes drug delivery and controlled release locally. Meanwhile, precise control and manufacturing also provide conditions for customized drug delivery platforms. Besides this, a complex spatial structure constructed based on 3D printing technology is also conducive to cell proliferation and differentiation, providing a new carrier for tissue engineering and repair. Biomedical applications based on 3D printing technology promote the development of precision medicine and personalized medicine and provide a new direction for further research and application of 3D printing technology.

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Reshaping the Inflammatory Environment in Rheumatoid Arthritis Joints by Targeting Delivery of Berberine with Platelet‐Derived Extracellular Vesicles

Cited by 11 publications

References 0 publications

Immunomodulatory nano-preparations for rheumatoid arthritis

Immunomodulatory nano-preparations for rheumatoid arthritis

Neurological Disorder after Severe Pneumonia is Associated with Translocation of Bacteria from Lung to Brain

Recent advances in 3D printing hydrogel for topical drug delivery

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