Recent advances in 3D printing hydrogel for topical drug delivery

Abstract

Polymer hydrogel has been used as a drug delivery carrier for many decades. Recently, the emergence of three‐dimensional (3D) printing technology has opened up a new area for applications of drug delivery based on polymer hydrogel. A series of drug delivery platforms based on 3D printing hydrogel are developed to achieve local delivery of small/large molecule drugs as well as therapeutic cells. Compared with other manufacturing technologies, 3D printing technology can achieve high‐precision personalized manufacturing and complex spatial structure construction, which has a wide application prospect in the biomedical field. In this review, we summarized the recent advances in 3D printed polymer hydrogels as delivery platforms in drug and cell topical delivery. 3D printed drug delivery platform realizes drug delivery and controlled release locally. Meanwhile, precise control and manufacturing also provide conditions for customized drug delivery platforms. Besides this, a complex spatial structure constructed based on 3D printing technology is also conducive to cell proliferation and differentiation, providing a new carrier for tissue engineering and repair. Biomedical applications based on 3D printing technology promote the development of precision medicine and personalized medicine and provide a new direction for further research and application of 3D printing technology.

Advances in Three Dimensional Bioprinting for Wound Healing: A Comprehensive Review

“…Like artificial organs and tissues, 3D hydrogel scaffolds designed for wound healing can also easily be produced using imaging modalities and computer-aided design software programs [254]. SEM images allow the analysis of the cross-sectional morphologies of 3D-printed hydrogels [130,[255][256][257][258][259].…”

3D printed drug loaded nanomaterials for wound healing applications

“…The hydrogels can be obtained from natural or synthetic sources though they can be composite using organic or nano organic fillers. The basic role of smart hydrogels depends on their swelling, shaping, hydrophilicity, and bioactivity in response to external stimuli such as temperature, pH, magnetic field, electromagnetic radiation, and biological molecules [ 1 , 163 ]. Smart hydrogels have opened a new horizon for scientists to fabricate biomimetic customized biomaterials for different applications including wound dressing, and controlled release of bioactive substances/drugs [ 53 ].…”

Enhancing antioxidant delivery through 3D printing: a pathway to advanced therapeutic strategies

“…The combination of 3D printing and antioxidants holds significant promise in the development of advanced therapeutic strategies ( Hong, Purushothaman, and Song, 2020 ). By incorporating antioxidants within 3D-printed matrices, it becomes possible to achieve controlled release and localized delivery, overcoming limitations associated with traditional antioxidant administration routes ( Zhang and Wang, 2022 ). Furthermore, the ability to tailor the release kinetics, spatial distribution, and degradation profiles of 3D-printed antioxidant systems offers opportunities for personalized medicine and individualized treatment approaches ( Bagheri et al, 2023 ).…”