Research trends in biomimetic medical materials for tissue engineering: 3D bioprinting, surface modification, nano/micro-technology and clinical aspects in tissue engineering of cartilage and bone

Abstract

This review discusses about biomimetic medical materials for tissue engineering of bone and cartilage, after previous scientific commentary of the invitation-based, Korea-China joint symposium on biomimetic medical materials, which was held in Seoul, Korea, from October 22 to 26, 2015. The contents of this review were evolved from the presentations of that symposium. Four topics of biomimetic medical materials were discussed from different research groups here: 1) 3D bioprinting medical materials, 2) nano/micro-technology, 3) surface modification of biomaterials for their interactions with cells and 4) clinical aspects of biomaterials for cartilage focusing on cells, scaffolds and cytokines.

Dual growth factor‐immobilized asymmetrically porous membrane for bone‐to‐tendon interface regeneration on rat patellar tendon avulsion model

“…From these observations, we recognized that the asymmetrically porous PCL/F127 membranes can act as a physical barrier to prevent fibrous tissues invasion and as a scaffold to guide tissue regeneration as well as a carrier for prolonged growth factor release for the regeneration of BTI injury. Sustained release of the single PDGF‐BB and BMP‐2 from the membrane showed the intrinsic efficacy of each growth factor (i.e., promotion of tendon cell proliferation and collagen synthesis by PDGF‐BB, and induction of cartilage and bone formation by BMP‐2); however, the single growth factor system may be insufficient to reconstruct the BTI with a multiphasic structure in our system. On the other hand, the Dual GF system may provide an appropriate environment to regenerate the BTI injury by the GTR/scaffold effect of the asymmetrically porous PCL/F127 membrane as well as the synergistic (complementary) effect of continuously released PDGF‐BB and BMP‐2 to create a multiphasic structure like the native structure.…”

Tissue engineering in orthopaedic sports medicine: current concepts

“…This novel strategy gives the possibility to produce 3D patient-specific scaffolds with tunable and advanced features. The control of porosity, permeability, surface properties, initial mechanical properties and biodegradation provides new approaches towards better and smarter TE strategies 31. In a recent study, Lee et al 32 produced a 3D bioprinted meniscal scaffold using polycaprolactone loaded with human connective tissue growth factor and TGF-β3 providing a biomimetic structure and a beneficial microenvironment for cell growth.…”

Lipid-based surface engineering of PLGA nanoparticles for drug and gene delivery applications

“…In recent years, several therapeutics based on poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) (hereinafter abbreviated PNPs) have entered into preclinical development or are being investigated in biomedical research, owing to their attractive properties of biodegradability, biocompatibility, ease of processing, and sustained release [5–8]. To optimize their clinical potential, considerable efforts have been devoted to understanding the mechanism of interaction between the PNP surface and its biological environment [9].…”