Research progress in the application of stable isotope and mineral element analysis in tracing the geographical origin of Chinese medicinal materials

Abstract

The Geographical Origin of Chinese medicinal materials plays an important role in guaranteeing the authenticity of Chinese medicinal materials, ensuring the quality and efficacy of Chinese medicinal materials, maintaining the market order, and reducing the risk of medical accidents caused by counterfeit Chinese medicinal materials. In recent years, there have been more and more research papers on tracing Chinese medicinal materials by stable isotope and mineral element analysis combined with chemometrics. Using stable isotope and mineral element analysis to trace traditional Chinese medicinal materials has the advantages of high accuracy and strong reliability. Through chemometrics methods, medicinal materials from different origins can be classified, distinguished, and modeled, and finally the purpose of origin traceability can be achieved. Based on the introduction of the basic principles of stable isotopes and mineral elements, this article systematically analyzes the research and application of relevant stable isotope and mineral element analysis techniques in the origin traceability of Chinese medicinal materials in the past 10 years, and proposes the existing problems in origin traceability of Chinese medicinal materials. This article aims at providing reference for the origin traceability, confirmation and supervision of Chinese herbal medicines, and promoting the establishment and improvement of the traceability technical system of Chinese herbal medicines.

Protected Geographical Indication Discrimination of Zhejiang and Non-Zhejiang Ophiopogonis japonicus by Near-Infrared (NIR) Spectroscopy Combined with Chemometrics: The Influence of Different Stoichiometric and Spectrogram Pretreatment Methods

“…There are many common methods for the origin tracing of traditional Chinese medicines, including stable isotope techniques [ 12 , 13 ], high-performance liquid chromatography (HPLC) analysis [ 14 ], DNA barcoding techniques [ 15 ], near-infrared (NIR) spectroscopy [ 16 , 17 ], and metal element analysis [ 18 , 19 ]. Meng et al determined the stable isotope of volatile compounds in wolfberry from Gansu, Ningxia and Qinghai by gas chromatography isotope ratio mass spectrometry (GC-IRMS), and combined this with one-way analysis of variance (ANOVA) for origin tracing, and reached a final accuracy 89.16%, 87.77%, and 85.87%, respectively [ 20 ].…”

A simple method for distinguishing Dendrobium devonianum and Dendrobium officinale by ultra performance liquid chromatography-photo diode array detector

“…The distribution of Dendrobium devonianum was mainly concentrated in the southeast to west of Yunnan, northwest Guangxi, southwest Guizhou (Wu et al, 2020), while the quality produced in Longling area was higher than that of Dendrobium officinale produced locally. Because the quality of Chinese medicinal materials was closely related to the environment of their origin (Liu et al, 2021;Xu et al, 2013;Zhang et al, 2022), the origin of Dendrobium officinale was not in the Longling area, but was an imported variety from other origins (Yan et al, 2020).…”