Rescue effects of ginger extract on dose dependent radiation-induced histological and biochemical changes in the kidneys of male Wistar rats

Saberi, Hassan; Keshavarzi, Behnaz; Shirpoor, Alireza; Gharalari, Farzaneh Hosseini; Rasmi, Yousef

doi:10.1016/j.biopha.2017.07.128

Cited by 20 publications

(16 citation statements)

References 46 publications

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“…Honey and royal jelly are effective in reducing cisplatin-induced acute kidney injury in cancer patients (Osama et al, 2017 ). Ginger extract shows renoprotective effects on radiotherapy-induced renal histological and biochemical alteration in rats (Saberi et al, 2017 ). Purslane ( Portulaca oleracea ), widely distributed around the globe in traditional medicine, significantly attenuates lipid alteration, liver, and kidney function as well as oxidative stress in irradiated rats (Abd El-Azime et al, 2014 ).…”

Section: Capacity To Relief Nephrotoxicitymentioning

confidence: 99%

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

et al. 2018

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Cancer is the second leading cause of death in the world. Chemotherapy and radiotherapy are the common cancer treatments. However, the development of adverse effects resulting from chemotherapy and radiotherapy hinders the clinical use, and negatively reduces the quality of life in cancer patients. Natural products including crude extracts, bioactive components-enriched fractions and pure compounds prepared from herbs as well as herbal formulas have been proved to prevent and treat cancer. Of significant interest, some natural products can reduce chemotherapy and radiotherapy-induced oral mucositis, gastrointestinal toxicity, hepatotoxicity, nephrotoxicity, hematopoietic system injury, cardiotoxicity, and neurotoxicity. This review focuses in detail on the effectiveness of these natural products, and describes the possible mechanisms of the actions in reducing chemotherapy and radiotherapy-induced side effects. Recent advances in the efficacy of natural dietary supplements to counteract these side effects are highlighted. In addition, we draw particular attention to gut microbiotan in the context of prebiotic potential of natural products for the protection against cancer therapy-induced toxicities. We conclude that some natural products are potential therapeutic perspective for the prevention and treatment of chemotherapy and radiotherapy-induced side effects. Further studies are required to validate the efficacy of natural products in cancer patients, and elucidate potential underlying mechanisms.

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Section: Capacity To Relief Nephrotoxicitymentioning

confidence: 99%

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

et al. 2018

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“…It has a long history in traditional medicine for the treatment of various diseases. Recent studies have shown that ginger and its extract possess a radioprotective effect [ 7 , 8 ]. Zingerone is an essential oil extracted from ginger that has various biological functions, including antioxidant, anti-inflammatory and antiapoptosis properties [ 9–12 ].…”

Section: Introductionmentioning

confidence: 99%

Protective effects of zingerone derivate on ionizing radiation-induced intestinal injury

Duan

Cui

et al. 2019

Journal of Radiation Research

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Abstract Intestinal injury is the primary toxicity of radiotherapy for pelvic and abdominal tumors, and it is also one of the common acute complications of radiotherapy. At present, there are no effective drugs to prevent intestinal injury in the clinic. Zingerone is a natural product with radioprotective effects. In this study, a novel compound (thiazolidine hydrochloride, TZC01) was synthesized by structural modification of zingerone. The effects of TZC01 on preventing intestinal injury from radiation were further investigated in this study. C57BL/6N mice were exposed to a lethal dose of abdominal irradiation (ABI) with and without TZC01 treatments. The morphological changes of the intestine and various makers of intestinal crypt cells were investigated. Treatment with TZC01 improved the survival rate of mice exposed to 12 Gy ABI. Moreover, TZC01 protected the intestinal morphology of mice, decreased the apoptotic rate of intestinal crypt cells, maintained cell regeneration and promoted crypt cell proliferation and differentiation. This study suggests that TZC01 has preventive and therapeutic effects on radiation enteritis by promoting the proliferation and differentiation of crypt cells to protect the small intestine from the toxic effects of ionizing radiation. Furthermore, the study of TCZ01 lays a strong foundation for developing novel radioprotectors with multiple properties.

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“…One enteric-coated tablet per day containing 200 mg of a highly standardized cranberry extract mitigated lower urinary tract infections and urinary symptoms such as dysuria, nocturia, urinary frequency, urgency when they were treated for 7 weeks. Ginger, extracted from Zingiber officinale , upregulated total antioxidant capacity (TAC) and downregulated 8-hydroxy-2′-deoxyguanosine (8-OhdG), CRP, cystatin C/creatinine ratio when pretreated in Wistar rat model for 10 days at doses of 50 mg/kg [ 101 ]. This indicated that ginger suppresses oxidative DNA damage, inflammatory reactions, histological and biochemical alterations in kidney tissues after γ-ray exposure.…”

Section: Sequela Of Radiotherapy and Plant Extractsmentioning

confidence: 99%

“…In addition, some natural products showed consistent efficacy in radiation-induced sequela even in different extraction methods. For example, Ginger hydro-alcoholic extract suppressed oxidative DNA damage and inflammatory reactions, ginger oleoresin showed mitigation of radiation-induced cell injury and ginger essential oil alleviated oxidative stress and clastogenic damage [ 101 , 102 , 103 ].…”

Section: Sequela Of Radiotherapy and Plant Extractsmentioning

confidence: 99%

Plant Extracts as Possible Agents for Sequela of Cancer Therapies and Cachexia

et al. 2020

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Cancer is a leading cause of the death worldwide. Since the National Cancer Act in 1971, various cancer treatments were developed including chemotherapy, surgery, radiation therapy and so forth. However, sequela of such cancer therapies and cachexia are problem to the patients. The primary mechanism of cancer sequela and cachexia is closely related to reactive oxygen species (ROS) and inflammation. As antioxidant properties of numerous plant extracts have been widely reported, plant-derived drugs may have efficacy on managing the sequela and cachexia. In this study, recent seventy-four studies regarding plant extracts showing ability to manage the sequela and cachexia were reviewed. Some plant-derived antioxidants inhibited cancer proliferation and inflammation after surgery and others prevented chemotherapy-induced normal cell apoptosis. Also, there are plant extracts that suppressed radiation-induced oxidative stress and cell damage by elevation of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and regulation of B-cell lymphoma 2 (BcL-2) and Bcl-2-associated X protein (Bax). Cachexia was also alleviated by inhibition of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) by plant extracts. This review focuses on the potential of plant extracts as great therapeutic agents by controlling oxidative stress and inflammation.

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Rescue effects of ginger extract on dose dependent radiation-induced histological and biochemical changes in the kidneys of male Wistar rats

Cited by 20 publications

References 46 publications

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

Protective effects of zingerone derivate on ionizing radiation-induced intestinal injury

Plant Extracts as Possible Agents for Sequela of Cancer Therapies and Cachexia

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