Protective effects of zingerone derivate on ionizing radiation-induced intestinal injury

Abstract

<jats:title>Abstract</jats:title> <jats:p>Intestinal injury is the primary toxicity of radiotherapy for pelvic and abdominal tumors, and it is also one of the common acute complications of radiotherapy. At present, there are no effective drugs to prevent intestinal injury in the clinic. Zingerone is a natural product with radioprotective effects. In this study, a novel compound (thiazolidine hydrochloride, TZC01) was synthesized by structural modification of zingerone. The effects of TZC01 on preventing intestinal injury from radiation were further investigated in this study. C57BL/6N mice were exposed to a lethal dose of abdominal irradiation (ABI) with and without TZC01 treatments. The morphological changes of the intestine and various makers of intestinal crypt cells were investigated. Treatment with TZC01 improved the survival rate of mice exposed to 12 Gy ABI. Moreover, TZC01 protected the intestinal morphology of mice, decreased the apoptotic rate of intestinal crypt cells, maintained cell regeneration and promoted crypt cell proliferation and differentiation. This study suggests that TZC01 has preventive and therapeutic effects on radiation enteritis by promoting the proliferation and differentiation of crypt cells to protect the small intestine from the toxic effects of ionizing radiation. Furthermore, the study of TCZ01 lays a strong foundation for developing novel radioprotectors with multiple properties.</jats:p>

Zingerone Alleviate Toxicity Induced by Cisplatin or Gamma Radiation in Rats by Modulating Pro-Inflammatory Mediators

“…Pretreatment of whole body radiation-exposure group with ginger showed significant improvement of oxidative stress. This coincided with the study of [24] reported that radiation induced reduction in intestinal tissue antioxidant enzyme levels such as superoxide dismutase, catalase, glutathione peroxidase, and glutathione which was reversed following administration of ginger essential oil.…”

“…High radiation doses cause death whereas sublethal doses may induce diverse diseases, such as cancer, cardiovas cular diseases and cataracts [22]. In addition, ionizing radiation may cause harm to normal tissue with many complications that affect biological and physiological systems so they should be protected [23,24].…”

Research progress on the mechanism of radiation enteritis

“…This paper concludes that pretreatment with TZC01 can significantly improve intestinal crypt apoptosis, increase the number of Lgr5+ ISCs, and even reduce intestinal cell apoptosis, thus protecting the intestinal barrier from IR damage. However, the mechanism of TZC01 is not explained in this paper ( 27 ).…”

A Study on the Therapeutic Mechanism of Liquiritin on Rats with Acute Chronic Liver Failure

“…Antiviral therapy, liver transplantation and artificial liver are common medical choices for the treatment of ACLF clinically, resulting in significantly reduced mortality, which, however, still exhibits an unsatisfied overall therapeutic effects 3 . It has been demonstrated that in the process of liver failure, the liver tissue is subjected to the triple lethal whammy of immune injury, hypoxic-ischemic injury and endotoxemia and the inflammatory response is the central link in the process of pathological progression 4 . Toll-like receptor 4 (TLR4) is an intracellular pattern recognition receptor that can activate the nuclear factors-κB (NF-κB) signaling pathway, which can induce an inflammatory cascade and participate in the inflammatory injury process of multiple diseases 5,6 .…”