Reproductive toxic effects of Tityus serrulatus scorpion venom in rats

Cruttenden, Karen; Nencioni, Ana Leonor Abrahão; Bernardi, Maria Martha; Dorce, Valquíria Abrão Coronado

doi:10.1016/j.reprotox.2008.04.011

Cited by 20 publications

(17 citation statements)

References 31 publications

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“…In a study demonstrating the central effects of T. serrulatus and T. bahiensis scorpion venom, it was shown that some of the animals injected with venom directly into the hippocampus had a great increase in HVA concentration, whereas others showed no alteration (Nencioni et al, 2009). In pregnant rats, changes in reproductive performance and an incomplete ossification of skull bones were observed only in some offspring of dams treated with T. serrulatus scorpion venom (Barão et al, 2008;Cruttenden et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Effects of a toxin isolated from Tityus bahiensis scorpion venom on the hippocampus of rats

Ossanai¹,

Lourenço²,

Nencioni³

et al. 2012

Life Sciences

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Section: Discussionmentioning

confidence: 99%

Effects of a toxin isolated from Tityus bahiensis scorpion venom on the hippocampus of rats

Ossanai¹,

Lourenço²,

Nencioni³

et al. 2012

Life Sciences

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“…Moreover, the IL-1 system is associated with an increased risk of placental and perinatal brain damage (Girard et al, 2010). It is possible that the alterations on IL-1 levels are responsible for the increase in weight of the placenta found in our previous works (Cruttenden et al, 2008;Dorce et al, 2014). Regarding IFN-g, we know that, along with other components of the immune system, it is involved in the process of neurogenesis (Yirmiya and Goshen, 2011).…”

mentioning

confidence: 87%

Tityus bahiensis scorpion venom injected to dams during pregnancy affects some cytokines of fetuses

Dorce

Frare

Paulo

et al. 2015

Toxicon

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“…While these disturbances are not shown in normal conditions of scorpion stings, experimental studies indicated that neonates have altered postnatal behavior implying the altered neurological function (7)(8)(9).…”

Section: Figurementioning

confidence: 97%

Embryotoxicity following repetitive maternal exposure to scorpion venom

Hmed¹,

Badraoui²,

Serria³

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

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Abstract:Although it is a frequent accident in a few countries, scorpion envenomation during pregnancy remains scarcely studied. In the present study, the effects of repetitive maternal exposure to Buthus occitanus tunetanus venom are investigated and its possible embryotoxic consequences on rats. Primigravid rats received a daily intraperitoneal dose of 1 mL/kg of saline solution or 300 µg/kg of crude scorpion venom, from the 7 th to the 13 th day of gestation. On the 21 st day, the animals were deeply anesthetized using diethylether. Then, blood was collected for chemical parameter analysis. Following euthanasia, morphometric measurements were carried out. The results showed a significant increase in maternal heart and lung absolute weights following venom treatment. However, the mean placental weight per rat was significantly diminished. Furthermore, blood urea concentration was higher in exposed rats (6.97 ± 0.62 mmol/L) than in those receiving saline solution (4.94 ± 0.90 mmol/L). Many organs of venom-treated rat fetuses (brain, liver, kidney and spleen) were smaller than those of controls. On the contrary, fetal lungs were significantly heavier in fetuses exposed to venom (3.2 ± 0.4 g) than in the others (3.0 ± 0.2 g). Subcutaneous blood clots, microphthalmia and total body and tail shortening were also observed in venom-treated fetuses. It is concluded that scorpion envenomation during pregnancy potentially causes intrauterine fetal alterations and growth impairment.

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Reproductive toxic effects of Tityus serrulatus scorpion venom in rats

Cited by 20 publications

References 31 publications

Effects of a toxin isolated from Tityus bahiensis scorpion venom on the hippocampus of rats

Effects of a toxin isolated from Tityus bahiensis scorpion venom on the hippocampus of rats

Tityus bahiensis scorpion venom injected to dams during pregnancy affects some cytokines of fetuses

Embryotoxicity following repetitive maternal exposure to scorpion venom

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