Tityus bahiensis scorpion venom injected to dams during pregnancy affects some cytokines of fetuses

Dorce, Ana Leticia Coronado; Frare, Eduardo Osório; Paulo, Maria Eliza F.V.; Dorce, Valquíria Abrão Coronado; Nencioni, Ana Leonor Abrahão

doi:10.1016/j.toxicon.2015.06.023

Cited by 5 publications

(4 citation statements)

References 28 publications

(32 reference statements)

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“…Some studies suggest that the scorpion venom provokes alterations in the maternal reproductive system in humans and in experimental animals [13, 25, 31, 37–39]. …”

Section: Effects Of Envenomation During Pregnancy On Prenatal Developmentioning

confidence: 99%

“…The peripheral activation of T cells is associated with an increase in the cellular proliferation and hippocampal neurogenesis [76]. The offspring of mothers treated with the venom during pregnancy or lactation had an increase on the level of cytokines [13, 59]. …”

Section: Effects Of Envenomation During Pregnancy On Postnatal Develomentioning

confidence: 99%

“…It was demonstrated that T. bahiensis venom injection during pregnancy decreases the level of INF-γ, IL-10 and TNF-α in the fetuses 24 h after the application, and it increases the level of IL-1α six hours after the application [13]. When the injection occurs during the lactation period, there is an increase in the cerebral level of INF-γ in pups 24 h after the maternal envenomation [59].…”

Section: Effects Of Envenomation During Pregnancy On Postnatal Develomentioning

confidence: 99%

“…Besides the release of neurotransmitters from the autonomic nervous system, scorpion venom may also provoke changes in the central nervous system, including epileptiform activity and neuronal damage in hippocampal neurons [5–10]. It is also responsible for tissue alterations, which lead to the release of inflammatory mediators such as cytokines [11–13]. …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Perinatal effects of scorpion venoms: maternal and offspring development

Dorce

Martins

Dorce

et al. 2017

J Venom Anim Toxins Incl Trop Dis

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Scorpion envenomation is a public health problem, especially in tropical and subtropical countries. Considering the high incidence of scorpionism in some areas, pregnant women and nursing mothers may be possible victims. Scorpion stings alter the release of neurotransmitters and some cytokines. These mediators act as organizers and programmers in the adequate formation of the nerves, and non-physiological concentrations of them during the brain organization originate disorders and diseases that can appear later in the life of the individual. Despite the importance of this subject, there are only a few studies showing the effects of scorpion venom on maternal reproductive development, in the morphology and physical and behavioral development of offspring. The present review article summarizes the major findings on this issue. Biochemical changes in the blood – such as hyperglycemia, increase on the level of sodium and on the creatinine concentration – are observed after scorpion sting in humans and experimental animals. Some studies in the literature demonstrate that the scorpion venom affects the maternal reproductive development in humans and in experimental animals, increasing the frequency and amplitude of uterine contraction and the number of resorptions. The venom can also lead to some alterations in the embryonic or fetal development increasing the total weight of fetuses and of some organs. Moreover, it affects the general activity and locomotion during childhood and adulthood, and the anxiety level in adult females and males. It also alters the number of hippocampal neurons and interferes in the level of some cytokines. Altogether, it is evident that the venom, when administered during the pregnancy or lactation, affects the development of the offspring. Studies are being conducted to determine the actual participation of the venom in the development of the offspring, and to what extent they are detrimental to animal development.

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“…Some studies suggest that the scorpion venom provokes alterations in the maternal reproductive system in humans and in experimental animals [13, 25, 31, 37–39]. …”

Section: Effects Of Envenomation During Pregnancy On Prenatal Developmentioning

confidence: 99%